Project Grant R35GM156520
Award Date
6/1/25
Completion Date
4/30/30
Dollars Obligated
$454K
Federal Agency
National Institute of General Medical Sciences
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
North Carolina, USA
Similar Awards
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $1,286,156 in funding to The Trustees of the University of Pennsylvania to conduct research on cytokinesis and the septin cytoskeleton. The 5-year project, starting on September 1, 2024, aims to address core issues regarding cytokinesis, including the architecture and constriction mechanism of the actomyosin ring, as...
This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award to Duke University, totaling $308,541, will support research to elucidate the fundamental mechanisms of cell division, known as cytokinesis, and its coordination with organelle division in the green alga Chlamydomonas reinhardtii. The project aims to identify the ancestral, actomyosin-independent mechanisms of cleavage furrow ingression, as well as the role of the actin cytoskeleton in...
North Carolina State University received a $232,136 Project Grant award from the National Science Foundation Division of Molecular and Cellular Biosciences to conduct collaborative research understanding and controlling force generation by a centrin-based contractile system. The research aims to elucidate the mechanism of myoneme contraction in the ciliate Spirostomum ambiguum, which represents the most powerful known biological force generation. The team will combine experiments and...
The University of Massachusetts (UMass) was awarded a $438,629 project grant (R35GM156188) by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859). The purpose of this 5-year project is to investigate the fundamental mechano-molecular mechanisms governing the high-fidelity process of cell division. The research will utilize advanced live-cell imaging, molecular, and biochemical methods to characterize the...
This $1,269,993 federal Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research to understand the molecular basis of how plant cells establish the division plane during cell division. The project aims to dissect the function of cytoskeletal motor assemblies at the cortical division site and determine how they connect to molecules in the phragmoplast, the structure that forms the new cell wall during cytokinesis. Researchers at...
This federal Project Grant award of $946,895 from the National Science Foundation's (NSF) Division of Molecular and Cellular Biosciences (CFDA 47.074 Biological Sciences) will fund research to advance the understanding of protein phosphorylation and its role in coordinating cell division. The project aims to identify new enzymes that carry out phosphorylation and the substrate proteins they modify to ensure proper cell division. Researchers will employ computational, biochemical, proteomic,...
This National Science Foundation Project Grant of $673,524 supports research at North Carolina State University to develop a mathematical model of mitosis through the Biological Sciences program (CFDA 47.074). The model will simulate chromosome segregation and nuclear envelope shape change coordination in fission yeast mitosis. Researchers will extend an existing mitosis model to include a deformable elastic nuclear envelope integrating the spindle, chromosomes, and nuclear envelope. They will...
The National Institute of General Medical Sciences (NIGMS) awarded a $541,967 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Chicago. The grant, valid from January 1, 2025 through December 31, 2029, supports research to expand the understanding of adherent cell mechanics and mechanobiology. Key focus areas include investigating the force-sensitive remodeling of cell-cell adhesions and the role it plays in contact inhibition of...
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $669,456 Project Grant to the University of Chicago under the Biological Sciences program (CFDA 47.074) for the project "Collaborative Research: Tools 4 Cells: Developing Next Generation Methods for Studying Cytoskeletal Factors in the Cell Nucleus". This 3-year project aims to develop novel tools to precisely perturb and study the role of the cytoskeletal protein actin within the cell...
This Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under CFDA Program 93.859 Biomedical Research and Research Training, supports research to investigate the molecular mechanisms that govern the self-organization and interactions of diverse actin cytoskeleton networks within cells. The $703,538 award, effective from July 1, 2024 through June 30, 2029, is funding work by researchers at the University of Chicago to address two key questions: 1) how...