Cooperative Agreement UG1EY025181

The National Eye Institute (NEI) awarded a $234,000 Project Grant (CFDA 93.867 - Vision Research) to Oregon Health & Science University (OHSU) to investigate the use of senolytic treatments to restore intraocular pressure (IOP) homeostasis in glaucoma. The project aims to explore how senotherapeutics that target senescent cells can enhance the efficacy of stem cell transplantation in the trabecular meshwork to restore the IOP homeostatic response, which is impaired in glaucoma. This research...

The National Eye Institute (NEI) awarded a $245,243 Project Grant (CFDA 93.867 - Vision Research) to Duke University to develop and validate a novel method for measuring ocular pulse amplitude (OPA) using fixed force applanation in normotensive and hypertensive eyes. The project aims to: 1) validate the applanation-based OPA measurement approach on non-human primates implanted with an intraocular pressure (IOP) telemetry system, and 2) assess the repeatability and reproducibility of OPA...

The National Eye Institute (NEI) has awarded a $362,415 Project Grant (CFDA 93.867 - Vision Research) to the University of Alabama at Birmingham (UAB) to study the role of orexins in regulating intraocular pressure (IOP) and its implications for glaucoma treatment. The five-year project aims to: Examine the impact of orexin receptor antagonists in the raphe pallidus on IOP elevation caused by stimulation of the dorsomedial hypothalamus and surrounding perifornical region. Assess the ability of...

This Project Grant award of $390,000 from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) supports research to assess the biomechanical and hydrodynamic effects of different drugs and treatments on modulating outflow facility in the eye. The goals are to improve understanding of intraocular pressure regulation mechanisms and dynamic outflow resistance, which could lead to new diagnostic and therapeutic biomarkers for glaucoma. Key activities include: Measuring...

This Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), provides $496,633 to Duke University to investigate the role of glypicans, specifically glypican-4 (GPC4), in regulating trabecular meshwork function, intraocular pressure, and the pathogenesis of glaucoma. The research aims to: 1) determine how increased GPC4 expression and secretion dysregulates Wnt and related signaling pathways to stimulate trabecular meshwork cell...

This Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), will support research to investigate the molecular mechanisms underlying cell death caused by mutant myocilin misfolding in glaucoma. The $447,479 award to Georgia TECH Research Corp, which operates as the Office of Sponsored Programs, will fund a 5-year project to use a yeast model system to screen for gene targets and small molecule compounds that can rescue the cytotoxicity...

The National Eye Institute (NEI), through the Vision Research federal grant program (CFDA 93.867), awarded a $185,000 Project Grant to the University of North Texas Health Science Center at Fort Worth (UNTHSC). The funding will support a 2-year research project to discover novel disease-modifying therapies for the prevention and treatment of glaucoma. The research will employ computational pharmacological approaches to identify small molecule inhibitors that can interfere with the GREM1-BMP...

The National Eye Institute (NEI) awarded a $433,125 federal Project Grant (CFDA 93.867 - Vision Research) to The Ohio State University to leverage data from the Collaborative Longitudinal Evaluation of Ethnicity and Refractive Error (CLEERE) study to address critical clinical questions in myopia control. The funded research aims to analyze axial length data to determine whom to treat and whether myopia control treatments are beneficial, assess the effects of time spent outdoors and sports...

This Cooperative Agreement award, with a total funding amount of $500,000.00, was provided by the National Center for Chronic Disease Prevention and Health Promotion, part of the Centers for Disease Control and Prevention (CDC), under the federal grant program "Centers for Research and Demonstration for Health Promotion and Disease Prevention" (CFDA 93.135). The award supports the Trustees of Columbia University in the City of New York, specifically its Health Sciences Division, in...

This federal Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), aims to develop an accurate, safe, and wearable intraocular pressure (IOP) monitoring device for the clinical management of glaucoma. The key goals are to: 1) Develop a prototype contact lens-based IOP sensor using atomic force microscopy; 2) Establish an empirical model relating indentation measurements to IOP; and 3) Assess the impact of sensor indentation on the human...