This $148,568 federal Project Grant awarded by the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) supports research conducted by Emory University to investigate the role of scleral fibroblasts in refractive development and myopia. The study aims to identify the characteristics of scleral fibroblasts in emmetropic eyes and compare changes that occur in mice exposed to myopic stimuli, including lens-induced myopia and retinoic acid treatment. The research also seeks...
The National Eye Institute (NEI) awarded a $494,418 Project Grant (CFDA 93.867 - Vision Research) to the University of Alabama at Birmingham (UAB) to conduct research on myopia and the visual environment. The project aims to: 1) Determine the anti-myopia effectiveness of a range of real-world visual scenes, 2) Develop an improved repeated low-level red light (RLRL) anti-myopia therapy, and 3) Develop objective recommendations for lighting spectra that could affect refractive eye development. The...
The National Eye Institute (NEI) has awarded a $441,375 Project Grant (CFDA 93.867 Vision Research) to the University of California, Berkeley to explore pharmacological avenues for improved myopia control. The project aims to investigate the use of a levodopa-carbidopa combination therapy, as well as a topical atropine-levodopa-carbidopa combination therapy, in a guinea pig model of myopia. The study will utilize advanced ocular imaging, functional testing, and gene expression analysis to...
This $210,534 Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) will support research to investigate the cellular, molecular, and structural changes underlying the development of juvenile myopia using a tree shrew model. The primary awardee, Legacy Emanuel Hospital & Health Center, will collaborate with the University of Alabama at Birmingham on the project. The key research activities include: Assessing alterations in axonal health,...
The National Eye Institute (NEI) awarded a $222,208 Project Grant (CFDA 93.867 - Vision Research) to The New England College of Optometry to investigate the effect of lens refractive index on the measurement of axial length of the human eye. The goal is to combine a ray-traceable Scheimpflug imaging system with a whole-eye optical coherence tomography (OCT) to simultaneously measure lens refractive index and axial length in vivo. This novel, non-contact system will be used to study changes in...
The National Eye Institute (NEI), through its Vision Research program (CFDA 93.867), has awarded a $816,750 Project Grant to the University of Alabama at Birmingham (UAB) to pilot test a novel wavelength-based method to control childhood myopia. The two-year project aims to determine the efficacy of amber contact lens wear for up to four hours per day in slowing myopia progression and axial elongation in 40 myopic children aged 8 to 12. This "proof-of-concept" study will test the...
The National Eye Institute (NEI) awarded a $248,999 Project Grant (CFDA 93.867 - Vision Research) to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University from May 1, 2025 to April 30, 2028. The grant supports research to investigate how neuronal synaptic activity and neurotransmitters, particularly glutamate, influence retinal angiogenesis and blood-retina barrier (BRB) development. The project aims to determine: 1) how modulation of glutamate levels affects retinal...
The National Eye Institute (NEI) awarded a Project Grant under the Vision Research program (CFDA 93.867) to The Ohio State University for a 5-year project titled "CGAS SIGNALING IN OXIDATIVE RETINAL DAMAGE". The $513,371 award, effective April 1, 2025, supports research to investigate the mechanisms by which oxidative stress triggers the release of self-DNA and subsequent activation of the cGAS-STING pathway in the retina and retinal pigment epithelium (RPE). The research aims to...
The National Eye Institute (NEI) awarded The Ohio State University a $458,517 Project Grant (CFDA 93.867 - Vision Research) to conduct research focused on understanding the role of monocytes in neuroprotection and axon regeneration after traumatic optic nerve injury. The research aims to determine how interactions between neutrophils and monocytes lead to the polarization of monocytes towards a reparative phenotype, as well as explore the contributions of retinal microglia in modulating the...
The National Eye Institute (NEI) awarded a $665,243 Project Grant under the Vision Research program (CFDA 93.867) to The Ohio State University for the project "Enhancement of RGC Survival and Optic Nerve Regeneration by Cytokine Polarized Myeloid Cells". The objective is to elucidate the mechanisms by which polarized bone marrow-derived myeloid cells can promote retinal ganglion cell (RGC) survival and optic nerve regeneration, with the goal of informing the development of autologous...