The National Eye Institute (NEI) awarded a $362,415 Project Grant (CFDA 93.867 - Vision Research) to the University of Alabama at Birmingham (UAB) to investigate the role of orexins in regulating intraocular pressure (IOP) for the treatment of glaucoma. The project aims to examine the mechanisms by which the orexin neurotransmitter system in the central nervous system, specifically the dorsomedial hypothalamus/perifornical region and the raphe pallidus, modulates IOP fluctuations....
The National Eye Institute (NEI) awarded a $491,466 Project Grant (CFDA 93.867 - Vision Research) to The Regents of the University of California, San Francisco (UCSF) to develop a novel, non-invasive, and sensitive measure of retinal dysfunction. This grant aims to expand upon UCSF's preliminary findings that graded cone loss can be detected by measuring a visually-evoked compensatory behavior known as the optokinetic reflex (OKR). The primary goals are to (1) develop OKR-inducing stimuli...
The National Eye Institute (NEI) awarded a $245,243 Project Grant (CFDA 93.867 - Vision Research) to Duke University to develop and validate a novel method for measuring ocular pulse amplitude (OPA) using applanation-based tonometry. The project aims to: 1) Validate OPA measurements on non-human primates with implanted IOP telemetry systems in normotensive and hypertensive eyes; and 2) Assess the repeatability and reproducibility of OPA measurements in normotensive and hypertensive human eyes....
This federal Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), provides $496,633 in funding to Duke University to conduct research on the role of glypicans, specifically glypican-4 (GPC4), in regulating trabecular meshwork function, intraocular pressure, and the development of glaucoma. The research aims to uncover the mechanisms by which increased GPC4 levels in the aqueous humor outflow pathway can dysregulate Wnt and growth factor...
This federal Project Grant award from the National Eye Institute (NEI), under the NEI Vision Research program (CFDA 93.867), will support research to develop robust corneal biomechanical biomarkers for glaucoma using Brillouin microscopy. The $230,430 award to the University of Maryland, Baltimore will fund a two-year study with the following key objectives: Compare the corneal Brillouin modulus between primary open-angle glaucoma (POAG) patients and age-matched controls to determine if POAG...
The National Eye Institute (NEI) awarded a $1,066,178 Project Grant under the 93.867 Vision Research program to Tavo Biotherapeutics, Inc. (operating as Oculo Therapy LLC), a woman-owned small business. The funding supports late-stage preclinical development and GMP production of a novel, extended-release intraocular pressure (IOP)-lowering topical formulation using the FDA-approved drug pregabalin to address significant unmet needs in glaucoma treatment. The key aims are to develop a...
This Project Grant award of $409,375 from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) supports research to investigate the biomechanical properties of the optic nerve head and their relationship to the development and progression of open-angle glaucoma. The 5-year study will use optical imaging and finite element modeling to measure deformations and mechanical properties of the optic nerve head tissues in glaucoma patients under varying intraocular pressure...
This Project Grant award from the National Eye Institute (NEI), under the Federal Grant Program for Vision Research (CFDA 93.867), provides $234,000.00 in funding from February 1, 2025 to January 31, 2027. The funding supports research to explore the use of senolytic treatments and stem cell transplantation to restore intraocular pressure (IOP) homeostasis in glaucoma patients. The research aims to determine if removing senescent trabecular meshwork cells and/or transplanting stem cells can help...
This Project Grant award from the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867) provides $390,000.00 in funding to Oregon Health & Science University (OHSU) from July 1, 2024 to May 31, 2029 to support research aimed at assessing the biomechanical and hydrodynamic effects of different drugs and treatments on modulating outflow facility for the treatment of primary open-angle glaucoma (POAG). The key objectives are to: 1) determine low-flow and...
This Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) provides funding to investigate changes in the extracellular matrix (ECM) of the ocular outflow pathway that contribute to elevated intraocular pressure (IOP) and open-angle glaucoma. The $661,635 award to The Research Foundation for the State University of New York (RFSUNY), effective April 1, 2025 through March 31, 2029, aims to elucidate the molecular ECM changes underlying...