Cooperative Agreement U01FD005773

This Cooperative Agreement award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program provides $1,250,000 in funding to Zaiput Flow Technologies LLC, a small business manufacturer based in Waltham, Massachusetts. The award supports the further development of an innovative continuous crystallization device for pharmaceutical manufacturing. The key objectives are to create a scalable, cost-effective, and consistent crystallization process that...

This Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) provides $463,746 to the University of Puerto Rico Medical Sciences Campus (UPR-MSC) to study an innovative continuous crystallizer concept. The objective is to develop robust, scalable, and miniaturized equipment for pharmaceutical manufacturing that can improve resilience to supply chain disruptions and better meet fluctuating market needs. The research seeks to advance continuous...

Zaiput Flow Technologies LLC received a $275,000 Project Grant award from the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084) to develop an innovative, continuous crystallization device for pharmaceutical manufacturing. The goal is to improve the purification process of active pharmaceutical ingredients, which is a critical step used in over 90% of pharmaceutical production. The novel device aims to address scalability, cost, and...

This SBIR Phase II Cooperative Agreement, awarded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084), provides $1,213,322 in funding to Lavo Life Sciences Inc. to develop a physics-based machine learning platform for predicting the crystal structure of small drug molecules. The objective is to accelerate the development and commercialization of new pharmaceutical products by optimizing drug product formulations and solid forms....

The National Science Foundation awarded a $249,884 Project Grant to the Regents of the University of Minnesota under the NSF Technology, Innovation, and Partnerships federal grant program (CFDA 47.084) to develop a decentralized, on-demand production system for large volume parenteral solutions and medical fluids. The University will implement a proof-of-concept prototype capable of producing 100 L/hr of solutions such as electrolyte replacement, intravenous fluids, and dialysis mixtures on-site...

The National Science Foundation awarded Diant Pharma Inc. a $256,000 Project Grant under the Engineering (47.041) federal grant program. The grant will support development of an advanced continuous manufacturing system for nucleic acid lipid nanoparticles to improve supply chains for therapeutics and vaccines. Specifically, the small business innovation research Phase I project aims to create a compact, end-to-end manufacturing platform that follows current good manufacturing practices. This...

The National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation awarded Purdue University a $766,734 Project Grant under the Engineering federal grant program (CFDA 47.041) from September 1, 2021 to August 31, 2024. The grant funds the RIGHT FIRST TIME MANUFACTURE OF PHARMACEUTICALS (RIFTMAP) project. RIFTMAP aims to improve quality control and reduce waste in pharmaceutical manufacturing through research focused on ensuring correct, compliant production processes...

This Cooperative Agreement award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) provides $1,000,000 in funding to the Virginia Biotechnology Research Park Corporation (dba Activation Capital) to develop a robust pharmaceutical cluster program called the Alliance for Building Better Medicine in the Richmond/Petersburg region of Virginia. Over an 18-month period, the awardee will work with 23 core partners, including three direct...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports the development of a novel in-line biomanufacturing process analytical technology tool. The $302,417 award to Physical Sciences Inc. (PSI), in collaboration with the University of Massachusetts Lowell (UML), aims to enable real-time monitoring of biomolecules in large-scale bioreactors for gene therapy manufacturing. The technology...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program provides $306,860 to Mixedlcmedia LLC, a small disadvantaged business, to develop and evaluate a prototype ultra-low flow liquid chromatography platform based on their proprietary porous layer open-tubular (PLOT) and monolithic nanocolumn technologies. The goal is to create a commercialization-ready LC system that enables deep proteomic...