Sol_75N98026Q00547.pdf

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National Institutes of Health OD - Office of Logistics and Acquisition Operations 6100 Executive Blvd., Room 6B05 Bethesda, MD 20892-7511

75N98026Q00547

NICHOLAS CAPOBIANCO

+10

000-000000

06/08/2026

06/15/2026 0900 ED

Multiple

The purpose of this NON-COMPETITIVE

COMBINED SYNOPSIS / SOLICITATION is to acquire untargeted metabolomics analysis using the Metabolon global metabolomics platform on plasma samples derived from a non-human primate (NHP) bacterial sepsis model.

Period of Performance: 06/16/2026 to

12/16/2026

This contract incorporates one or more clauses by reference, with the same force and effect as if they were given in full text. Upon request, the contracting officer will make their full text available. Also, the full text of a

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NSN 7540-01-152-8067

75N98026Q00547 clause may be accessed electronically at this address:

HTTPS://ACQUISITION.GOV/FAR

The following FAR clauses and Provisions are applicable to this award.

FAR 52.204-13 System for Award Management

Maintenance (Oct 2018);

FAR 52.204-18 Commercial and Government Entity

Code Maintenance (Aug 2020);

HHSAR 352.222-70, Contractor Cooperation in

Equal Employment Opportunity Investigations

(Dec 2015).

FAR 52.212-4 Contract Terms and Conditions -In addition to all the applicable commercial

Products and Commercial Services (Nov 2023)

FAR 52.212-5 Contract Terms and Conditions

Required to Implement Statutes or Executive

Orders/Commercial Products and Commercial

Services (Jan 2025)

FAR 52.217-8 Option to Extend Services (Nov

1999)

FAR 52.252-2 CLAUSES INCORPORATED BY REFERENCE

To avoid delay in payment, all invoices must be uploaded into the invoicing processing platform

(IPP) (https://www.ipp.gov). The invoice must match the line item description on the purchase order. It must also state that payment is to be made using a three-way match.

NON-COMPETITIVE

COMBINED SYNOPSIS / SOLICITATION

Title: RCT NHP Sepsis Blood Samples and Characterization of Neutrophils Subsets and Their Relevance to Sepsis Outcome in Clinical Setting

(i) This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in FAR Subpart 12.6, as supplemented with additional information included in this notice.

This announcement constitutes the only solicitation; proposals are being requested, and a separate written solicitation will not be issued.

(ii) The solicitation number is 75N98026Q00547. This solicitation is issued as a Notice of Intent (NOI) for a non-competitive combined synopsis/solicitation to award a brand-name purchase order without providing for full and open competition.

This acquisition is conducted under the authority of FAR 12.603, Streamlined Solicitation for Commercial Products or Commercial Services, and is not expected to exceed the simplified acquisition threshold. Additional authority includes 41 U.S.C. 1901 and FAR 6.302-3(a)(2)(ii).

The National Institutes of Health (NIH), Office of the Director, Office of Acquisitions, intends to negotiate and award a firm-fixed-price purchase order on a non-competitive basis to:

Metabolon 617 Davis Drive, Suite 400 Morrisville, NC 27560-7171 for high-resolution, untargeted metabolomics analysis using the Metabolon global metabolomics platform in support of the National Heart, Lung, and Blood Institute (NHLBI), Laboratory of Critical Illness, in the characterization of neutrophil metabolic profiles from a non-human primate (NHP) bacterial sepsis model.

(iii) The solicitation document and incorporated provisions and clauses are those in effect through the most current Federal Acquisition Circular.

(iv) The associated NAICS code is 541380, Testing Laboratories and Services, and the small business size standard is $19.0 million. This requirement is not set aside for small business.

(v) Description of Requirement:

The NHLBI Laboratory of Critical Illness requires untargeted metabolomics analysis using the Metabolon global metabolomics platform on plasma samples derived from a non-human primate (NHP) bacterial sepsis model. The platform must be capable of simultaneously detecting and quantifying over 5,000–6,000 biochemicals across diverse metabolic pathways, providing comprehensive coverage of central carbon metabolism, lipid metabolism, amino acid metabolism, and inflammatory metabolic networks.

Plasma samples will be analyzed using Metabolon's proprietary LC-MS-based analytical workflow, which integrates automated sample preparation, high-resolution mass spectrometry, and advanced compound identification pipelines. Contractor responsibilities include: sample processing and metabolite extraction using validated protocols; untargeted LC-MS-based metabolomic profiling; metabolite identification, annotation, and quantification; data normalization, quality control, and batch correction; delivery of raw and processed datasets suitable for downstream statistical and pathway analysis; and provision of metadata, QC reports, and analytical documentation supporting reproducibility.

The Metabolon platform has been previously implemented in the requesting laboratory, generating existing datasets used in ongoing analyses. Continuity of this platform is scientifically critical, as any change in analytical provider would introduce batch effects, reduce comparability, and compromise longitudinal integration across studies. No other commercially available provider offers comparable breadth of metabolite coverage, depth of biochemical annotation, or validated consistency with existing datasets generated using the Metabolon platform.

Period of Performance: Six (6) months after receipt of order (ARO).

(vi) Delivery Location:

NHLBI 10 Center Drive, Building 10-CRC, Room 5E-3233 Bethesda, MD 20892 USA

(vii) [Reserved]

(viii) The provision at FAR 52.212-1, Instructions to Offerors—Commercial Items, applies to this acquisition.

(ix) The provision at FAR 52.212-2, Evaluation—Commercial Items, applies to this acquisition.

(a) A written notice of award or acceptance of an offer, issued to the successful offeror within the time specified in the offer, shall result in a binding contract without further action by either party.

The Government reserves the right to accept any offer (or part of an offer) before the expiration date, whether or not discussions are conducted, unless a written notice of withdrawal is received prior to award.

(x) Offerors shall include a completed copy of FAR 52.212-3, Offeror Representations and Certifications—Commercial Items, with their offer.

(xi) FAR 52.212-4, Contract Terms and Conditions—Commercial Items, applies to this acquisition.

(xii) FAR 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders—Commercial Items, applies to this acquisition.

(xiii) Additional contract requirements or terms and conditions, as determined necessary by the Contracting Officer and consistent with customary commercial practices: None.

(xiv) The Defense Priorities and Allocations System (DPAS) is not applicable to this requirement.

(xv) Submission Requirements:

Responses must include sufficient information to demonstrate the respondent's capability to provide the required product or service. Price quotations shall include, at a minimum: unit price, list price, shipping and handling costs, delivery timeframe after award, delivery terms, prompt payment discount terms, F.O.B. point (destination or origin), product or catalog numbers, product descriptions, and any other relevant information.

Evaluation factors may include, but are not limited to: past performance, technical capability, special features, trade-in considerations, expected lifecycle, warranty, maintenance availability, and environmental or energy efficiency considerations.

Respondents claiming to be manufacturers or authorized resellers of the specified brand-name product must provide:

(a) Product, catalog, model, and/or part number(s); (b) Product description; (c) Documentation demonstrating that the offered item meets all required salient characteristics; (d) Quantity; (e) Estimated price or cost; (f) Shipping, handling, and/or installation charges; and (g) Delivery timeframe after receipt of order.

Responses must also include the Unique Entity Identifier (UEI), Taxpayer Identification Number (TIN), and business size certification. All offerors must be actively registered in the System for Award Management (SAM) at www.sam.gov.

All responses must be received by Monday, June 15, 2026 at 9:00 AM EDT and must reference solicitation number 75N98026Q00547. Responses may be submitted electronically to nicholas.capobianco@nih.gov.

This notice of intent is not a request for competitive quotations. However, all responsible sources may submit a capability statement, proposal, or quotation, which shall be considered by the Agency. A determination by the Government not to compete this proposed contract action based upon responses to this notice is solely within the discretion of the Government.

mailto:nicholas.capobianco@nih.gov

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