CTR061681 A2_Executed.pdf

INTERAGENCY SERVICE AGREEMENT

(ISA) AMENDMENT

ARIZONA DEPARTMENT OF

HEALTH SERVICES

OFFICE OF PROCUREMENT

150 N. 18th Ave., Ste. #530

Phoenix, Arizona 85007

AGREEMENT No.: CTR061681 AMENDMENT No.:2

PROCUREMENT OFFICER

Kaitlin Burreson

ARIZONA BIOMEDICAL RESEARCH CENTRE (ABRC) EDUCATIONAL INITIATIVE

Effective upon final signature by both parties, it is mutually agreed that the Agreement referenced in this Amendment is revised as follows:

1. Pursuant to the Uniform Terms and Conditions, Provision Twelve (12), Miscellaneous, Section 12.4, the Agreement is hereby revised with the following:

1.1. The Scope of Services has been revised and replaced; and

1.2. The Price Sheet has been revised and replaced.

REVISIONS ARE IN RED

ALL OTHER PROVISIONS SHALL REMAIN IN THEIR ENTIRETY.

Contractor hereby acknowledges receipt and acceptance of above amendment and that a signed copy must be filed with the Procurement Office before the effective date.

The above referenced Contract Amendment is hereby executed this __________ day of ______________, 20______ at Phoenix, Arizona.

Signature and Date

Authorized Signatory’s Name and Title

AZ Board of Regents, on behalf of The University of Arizona

Procurement Officer Signature Contractor’s Name

INTERAGENCY SERVICE AGREEMENT (ISA)

AMENDMENT

ARIZONA DEPARTMENT OF

HEALTH SERVICES

OFFICE OF PROCUREMENT

150 N. 18th Ave., Ste. #530

Phoenix, Arizona 85007

AGREEMENT No.: CTR061681 AMENDMENT No.:2

PROCUREMENT OFFICER

Kaitlin Burreson

1. Background

The Arizona Department of Health Services (ADHS), Arizona Biomedical Research Centre (ABRC) is an educational partner for the Arizona Researchers. The ABRC Educational Program brings high quality educational and training resources to local researchers to support them in becoming successful and nationally recognized researchers. The Research Education Program partners with local universities to support local researchers and clinical professionals by bringing national and local experts together to cover emerging topics at little or no cost to the Arizona research community.

2. Objective

The objective of this Agreement is to work with the University of Arizona, Tucson, in order to organize a series of workshops and other educational activities in the Tucson area for the University, hospital researchers, and community members.

3. Tasks

The University shall:

3.1. Partner collaboratively whenever possible with identified organizations to fulfill this mission on behalf of the

ADHS ABRC;

3.2. Design and implement each of the workshops in collaboration with relevant community partners and multidisciplinary units within the University;

3.3. Make workshops open to the general public, with special emphasis on university, hospital, community health center, other community based public health-oriented institutions;

3.4. Provide workshops free of charge to participants;

3.5. Provide distance learning/participation opportunities for all events during pandemics or other times when physical gatherings are restricted;

3.6. Include the ABRC Program Director in event planning committees; and

3.7. Fund, create and host the following events on behalf of the ABRC Research Education Program:

3.7.1. Clinical Trials Development Workshop V (Rachna Shroff, MD, MS, Interim Chief of Hematology/Oncology Division, Associate Dean of Clinical and Translational Research and Associate Director of Clinical Investigations of University of Arizona Cancer Center Clinical Trials Office) The fifth (5th) workshop follows the highly successful Clinical Trials Development workshop that took place in April 2023. The next workshop will delve deeper into specific aspects of designing clinical trials and developing proposals for clinical trials and will be marketed to attendees of the first four (4) workshops as well as faculty, fellows, residents, and medical students (feedback from which indicated a deeper dive into some of these topics) in addition to a broader audience including researchers and clinicians from institutions across Southern Arizona.

3.7.1.1. Examples of topics include participant selection and retention, writing Institutional Review Board (IRB) protocols, conflict of interest, and research project management;

3.7.1.2. One (1) half-day Workshop;

3.7.1.3. Target attendance at a minimum of fifty (50) participants; and

ARIZONA DEPARTMENT OF

HEALTH SERVICES

OFFICE OF PROCUREMENT

150 N. 18th Ave., Ste. #530

Phoenix, Arizona 85007

AGREEMENT No.: CTR061681 AMENDMENT No.:2

PROCUREMENT OFFICER

Kaitlin Burreson

3.7.1.4. The College of Medicine – Tucson shall:

3.7.1.4.1. Advertise the event and encourage broad participation statewide, and

3.7.1.4.2. Submit to ABRC via Box, event photos, which may be used by ABRC for promotional and reporting purposes; a summary of the event, event materials and participant feedback.

3.7.2. NOWS the Time: A Collaborative Care Workshop for the Treatment of Neonatal Opioid Withdrawal Syndrome (Todd Vanderah, PhD, Professor and Head, Department of Pharmacology and Director, UArizona Comprehensive Pain and Addiction Center, Jason Wertheim, MD, PhD, Vice-Dean for Scientific Initiatives;) This workshop is designed for those who provide care for mothers with substance use disorder (SUD), infants with neonatal opioid withdrawal syndrome (NOWS) or neonatal abstinence syndrome (NAS), and families caring for mothers and infants experiencing these challenges. The March 30, 2023 event drew 123 attendees, and featured the following topics, “The Neonatal Abstinence Syndrome Score: Historical Perspective and Clinical Application", "Opioids and Pregnancy: Myths, Principles, and Gaps in Care", "Postpartum Support for Those in Recovery", and "Advancements in Treatment with Opioids".

3.7.2.1. Organize a day-long collaborative conference for biomedical researchers;

3.7.2.2. Target attendance at a minimum of 100 participants;

3.7.2.3. The College of Medicine – Tucson shall:

3.7.2.3.1. Form a planning committee specific to this event,

3.7.2.3.2. Advertise the event and encourage broad participation state-wide to include the community and industry, and

3.7.2.3.3. Submit to ABRC via Box, event photos, which may be used by ABRC for promotional and reporting purposes, a summary of the event, event materials and participant feedback.

3.7.3. Research Day (Jason Wertheim, MD, PhD, Vice-Dean for Research and Graduate Studies; Anne Cress, PhD, Vice Dean of Operations and Strategy; Rachna Shroff, MD, MS, Interim Chief of Hematology/ Oncology Division, Associate Dean of Clinical and Translational Research) This will be the Fifth (5th) annual, day-long event organized to spur interdisciplinary research collaboration between basic scientists and clinicians. (Note: the past four (4) events were only made possible because of funds from the ABRC.) The event will feature keynote talks from experts in translational research, data blitzes, hands-on demonstrations, a virtual poster session highlighting medical student research, and a panel discussion of women in medicine and science. Our event this year took place on Wednesday, March 26, 2023, and featured more than 150 researchers that shared their unique projects, and three (3) TEDxstyle talks [one (1) internal speaker and two (2) external speakers (i.e., 2021 Nobel Prize Laureate in Physiology or Medicine, David Julius and Professor of Cellular and Molecular Pharmacology at the University of California at San Francisco, Holly Ingraham) that exposed over 500 attendees to the frontiers of innovative biomedical research. The event closed with a session that highlighted exemplary MD/PhD students as the rising class of future research innovators.

3.7.3.1. The event will be One (1) day-long event;

3.7.3.2. Target attendance at a minimum of 500 hundred participants;

ARIZONA DEPARTMENT OF

HEALTH SERVICES

OFFICE OF PROCUREMENT

150 N. 18th Ave., Ste. #530

Phoenix, Arizona 85007

AGREEMENT No.: CTR061681 AMENDMENT No.:2

PROCUREMENT OFFICER

Kaitlin Burreson

3.7.3.3. Invitees shall include biomedical researchers across Arizona, students, and the community;

3.7.3.4. The College of Medicine – Tucson shall:

3.7.3.4.1. Form a planning committee specific to this symposium,

3.7.3.4.2. Advertise the event and encourage broad participation state-wide to include the community and industry, and

3.7.3.4.3. Submit to ABRC via Box, event photos, which may be used by ABRC for promotional and reporting purposes, a summary of the event, event materials and participant feedback.

3.7.4. Translational Research Workshop (Cori Daines, MD, Division Chief of Pediatrics and Project Director of the Pediatric Pulmonary Center). This half-day workshop will demystify translational research and help both basic and clinical scientists enter into bench-to-bedside research collaborations that could lead to new interventions, medical devices, diagnostics, and therapeutics. It will be marketed to all biomedical research constituencies, with a special emphasis on junior faculty, post-docs, clinical fellows, graduate students and upper-division undergraduate students. Content will include: how to translate a basic science study into the clinic, working with industry partners, tips for early clinical investigators, the role of a clinical scientist, tips on how to leverage translatable ideas into funded research, Phase I trials and more. Two (2) keynote speakers who have successfully translated a discovery in their laboratory into a treatment that is currently being used in the clinic will be invited to share their knowledge and experiences (both the good and bad) on this topic. The keynote speakers at the April 15, 2023 event were the Director of Translational Research, Jennifer Carew, and the Associate Director of Translational Research at the Asthma & Airways Disease Research Center, Julie Ledford.

3.7.4.1. Event will be One (1) half-day event for biomedical researchers;

3.7.4.2. Target attendance at a minimum of fifty (50) participants;

3.7.4.3. Invitees shall include biomedical researchers across Arizona including junior faculty, post-doctoral and clinical fellows, residents and graduate students;

3.7.4.4. The College of Medicine – Tucson shall:

3.7.4.4.1. Form a planning committee specific to this workshop, and

3.7.4.4.2. Advertise the event and encourage broad participation state-wide to include researchers from Arizona State University (ASU), Northern Arizona University (NAU), Translational Genomic Research Institute (TGen), and other Arizona biomedical research institutions;

3.7.5. Chronic Pain and the Opioid Crisis: Perception and Reality Conference (led by Todd Vanderah, PhD, Professor and Head, Department of Pharmacology and Director, UArizona Comprehensive Pain and Addiction Center, Frank Porreca Director of the National Institutes of Health (NIH) P30 Center Grant on Addiction Studies). The significant public health crisis and individual burden of pain has received increasing recognition, especially in Arizona. The crisis highlights the challenges the pain field faces as it tries to develop better treatment and management strategies for patients and health professionals, and has led to the establishment of the UArizona Comprehensive Pain and Addiction Center in March 2020. As a continuation of the center’s efforts, we organized a full-day conference on

ARIZONA DEPARTMENT OF

HEALTH SERVICES

OFFICE OF PROCUREMENT

150 N. 18th Ave., Ste. #530

Phoenix, Arizona 85007

AGREEMENT No.: CTR061681 AMENDMENT No.:2

PROCUREMENT OFFICER

Kaitlin Burreson

March 28, 2023 to bring together scientists, physicians, patients, the pharmaceutical industry, and government officials to address critical questions for the field. Topics included: “An overview of conopeptides and constellation pharmacology: a potential platform for uncovering new molecular targets and new leads for pain”, “Cortical circuits of pain unpleasantness and pain-related co-morbidities'', “Gut feelings – probing mechanisms of visceral pain”, and “Prolactin receptor dysregulation selectively promotes pain in females. Activities will include twenty-eight (28) poster sessions (with emphasis to include undergraduate and graduate students, as well as postdoctoral fellows). Engage internationally recognized scientists, pain physicians & addiction specialists, biomedical engineers, patients, industry partners, government officials, and members of the Food and Drug Administration (FDA) and NIH as speakers. Engage faculty at all three state Universities to encourage collaboration and joint future projects and federal funding. We will heavily emphasize young investigators (postdoctoral fellows and graduate student trainees and new junior faculty), women and under- represented groups. We will invite our rural health care partners in our paraprofessional training program for substance use disorder.

3.7.5.1. This event will be one (1) full day-long event;

3.7.5.2. Target attendance at a minimum of 200 participants; and

3.7.5.3. The College of Medicine – Tucson shall:

3.7.5.3.1. Form a planning committee specific to this symposium,

3.7.5.3.2. Advertise the conference and encourage broad participation state-wide, and

3.7.5.3.3. Submit to ABRC via Box, event photos, which may be used by ABRC for promotional and reporting purposes, a summary of the event, event materials and participant feedback.

3.7.6. The Medical Scientist Training Program (MSTP) Retreat (led by Todd Vanderah, PhD, Professor and Head, Department of Pharmacology, George Fantry, MD, Associate Dean for Student Affairs and Admissions, Jason Wertheim, MD, PhD Vice-Dean for Scientific Initiatives). The University of Arizona College of Medicine (UACOM) Doctorate of Medicine and Philosophy (MD-PhD) retreat aims to welcome new students as well as provide a space for current students and faculty to network and present their progress in research and medicine. UA College of Medicine - Tucson (COM-T) has been awarded the National Institute of Health Medical Scientist Training Program (MSTP T32) grant as of July 1, 2021 and will be the only MSTP T32 in the state of Arizona. As such, this is an excellent opportunity to enroll and train students across the entire state. Format for presentations will be data blitz style and the event will open with a keynote address. The first (1st) retreat was held in the Summer of 2021 and will be continued annually thereafter. In-line with national trends for MD-PhD training this retreat with serve as a foundation for building collaborations within our program and the greater Arizona community. We will include multi-disciplinary sessions focusing on biomedical ethics, wellness/burnout, career development, scientific mentoring, ethics, grant writing and discussions centered around how to choose a laboratory research and summer rotations. In addition, all MD/PhD students will have an opportunity to present their research. It is to be marketed to all MD/PhD students at the University of Arizona College of Medicine Tucson and Phoenix Campuses, all program directors and both institutions, MTSP faculty mentors, and members of the University of Arizona Health Sciences Leadership. Trainees from UA-COM Tucson and Phoenix will be invited, and research collaborators will be invited from across the state, including ASU, NAU, and University of Arizona Health Sciences

(UAHS).

3.7.6.1. The event will be a two (2) day-long event for MD/PhD researchers at the University of Arizona College of Medicine Tucson and Phoenix, ARIZONA DEPARTMENT OF

HEALTH SERVICES

OFFICE OF PROCUREMENT

150 N. 18th Ave., Ste. #530

Phoenix, Arizona 85007

AGREEMENT No.: CTR061681 AMENDMENT No.:2

PROCUREMENT OFFICER

Kaitlin Burreson

3.7.6.2. Target attendance at a minimum of fifty (50) participants, and

3.7.6.3. Submit to ABRC via Box, event photos, which may be used by ABRC for promotional and reporting purposes, a summary of the event, event materials and participant feedback.

3.7.7. Friday Frontiers in Biomedical Science Series (led by Jason Wertheim, MD, PhD, Vice-Dean for Scientific Initiatives; Anne Cress, PhD, Deputy Dean for Research; and Rachna T. Shroff, MD, Associate Dean for Clinical and Translational Research). Each session features two (2) speakers who will each share twenty (20) -minute data blitzes of a basic and clinical sciences research team targeted at a lay audience to engage community experts and academic scientists at all stages of career development to promote discussion and hypothesis generating ideas and projects. Event will be open to all UA students and faculty. Topics will range from immunologic approaches to cancer therapy, substance misuse in maternal and child health populations, and navigating critical care needs during the pandemic. The event will include informal discussions of participants with the team during a light appetizer hour. Occurs first (1st) Friday of every month throughout the academic year.

3.7.7.1. This series will be nine (9) events;

3.7.7.2. Target attendance at a minimum of fifty (50) participants per event; and

3.7.7.3. The College of Medicine – Tucson shall:

3.7.7.3.1. Form a planning committee specific for these events and keep ABRC informed;

3.7.7.3.2. Advertise the event and encourage broad participation state-wide; and

3.7.7.3.3. Submit to ABRC via Box, event photos, which may be used by ABRC for promotional and reporting purposes, a summary of the event, event materials and participant feedback.

3.7.8. Community Education Events: Biomedical News to Use (led by Jason Wertheim, MD, PhD, Vice- Dean for Research and Graduate Studies; Jordan Karp, MD, Department Chair of Psychiatry, and Professor of Psychiatry; Kristen Rundell, MD, Department Chair of Family & Community Medicine, Professor of Family & Community Medicine). Education series in a Ted-style format to engage/provide useful information to communities in targeted health areas. These will be publicized and broadcast widely and will involve partnering with community leaders in Southern Arizona, the Veteran Affairs (VA) hospitals in Arizona, and throughout the state. Topics will include health disparities and differential access to biomedical care, biomedical partnerships across underrepresented populations, hot topics in Arizona public health policy, veterans’ health. Presentations will be video enhanced and archived for enduring use.

3.7.8.1. This series will consist of six (6) half-day events;

3.7.8.2. Target audience at a minimum of 100 participants per seminar, specifically targeting a community audience across the state; and

3.7.8.3. The College of Medicine – Tucson shall:

3.7.8.3.1. Form a planning committee specific developing content for these community education events and include ABRC staff,

3.7.8.3.2. Advertise the event and encourage broad participation state-wide, and

ARIZONA DEPARTMENT OF

HEALTH SERVICES

OFFICE OF PROCUREMENT

150 N. 18th Ave., Ste. #530

Phoenix, Arizona 85007

AGREEMENT No.: CTR061681 AMENDMENT No.:2

PROCUREMENT OFFICER

Kaitlin Burreson

3.7.8.3.3. Submit to ABRC via Box, event photos, which may be used by ABRC for promotional and reporting purposes, a summary of the event, event materials and participant feedback.

3.7.9. Children’s Postinfectious Autoimmune Encephalopathy (CPAE) Consortium Conference/ Professional Education. The Children’s Postinfectious Autoimmune Encephalopathy Center of Excellence at the University of Arizona Steele Children's Research Center (UA CPAE) has developed strong ties with researchers and centers throughout the United States (US) involved in researching and treating this condition. UA CPAE will coordinate four (4) consortium conferences where the physician-researchers can share their work and collaborate. Two (2) for the CPAE Consortium and two

(2) for Professional Education. The conferences will be conducted either on-line or in-person, based on travel viability and participant preferences. Following each conference, a report will be prepared documenting the conference proceedings, to include a compendium of current research projects.

3.7.9.1. This series will be a full day event each time;

3.7.9.2. Target audience: Twenty-five (25) to fifty (50) participants per seminar; and

3.7.9.3. The CPAE Center of Excellence at UA CPAE shall:

3.7.9.3.1. Form a planning committee specific to developing content for the Consortium Conferences and keep ABRC informed,

3.7.9.3.2. Advertise the event and encourage broad participation state-wide, and

3.7.9.3.3. Submit to ABRC via Box, event photos, which may be used by ABRC for promotional and reporting purposes, a summary of the event, event materials and participant feedback.

4. Deliverables

4.1. No less than thirty (30) days prior to the event, the University shall submit the agenda and budget to biomedical@azdhs.gov for review and approval;

4.2. Due thirty (30) days after each event, the University shall provide the following:

4.2.1. A report to include:

4.2.1.1. Subject covered;

4.2.1.2. Narrative of the event;

4.2.1.3. Objectives of the event;

4.2.1.4. Number of participants;

4.2.1.5. Background of participants (e.g. researcher, public, scientist);

4.2.1.6. Participating organizations; and

4.2.1.7. Outcome/Results.

4.2.2. CD (or cloud type file upload/download service, e.g. Box) of the event, to include the following:

ARIZONA DEPARTMENT OF

HEALTH SERVICES

OFFICE OF PROCUREMENT

150 N. 18th Ave., Ste. #530

Phoenix, Arizona 85007

AGREEMENT No.: CTR061681 AMENDMENT No.:2

PROCUREMENT OFFICER

Kaitlin Burreson

4.2.2.1. Event program/agenda;

4.2.2.2. Event photos, which may be used by ABRC for promotional and reporting purposes; and

4.2.2.3. Speaker posters and presentations, with their approval.

5. Exclusions and Limitations

5.1. Events that the school would host without this support are not eligible;

5.2. Credit-based or paid coursework are not allowed;

5.3. Participants cannot be charged without prior ABRC approval which will be considered on a case-by-case basis; and

5.4. Meals can only be provided with this funding if the event is longer than six (6) hours. Refreshments for shorter events should be limited to less than ten dollars ($10) per person per event.

6. Notices, Correspondence, Reports, Invoices and Payments

6.1. Notices, correspondence and reports from the University to ADHS shall be sent to:

John Garcia Program Director Arizona Department of Health Services 250 N. 17th Avenue, Suite 1219 Phoenix, AZ 85007 Telephone: (602) 364-3128 Email: biomedical@azdhs.gov

6.2. Notices and correspondence from ADHS to the University shall be sent to:

Marcel Villalobos Director The University of Arizona P.O. Box 210158B, Rm 538 Tucson, AZ 85721-0158

6.3. Payments from ADHS to the University shall be sent to: (University to complete)

The University of Arizona Sponsored Projects & Contracting Services PO Box 41867 Tucson, AZ 85717

6.4. CERs shall be submitted to: biomedical@azdhs.com.

INTERAGENCY SERVICE AGREEMENT

(ISA) AMENDMENT

ARIZONA DEPARTMENT OF

HEALTH SERVICES

OFFICE OF PROCUREMENT

150 N. 18th Ave., Ste. #530

Phoenix, Arizona 85007

AGREEMENT No.: CTR061681 AMENDMENT No.: 2

PROCUREMENT OFFICER

Kaitlin Burreson

Price Sheet

Effective July 1, 2023 to June 30, 2024

Reimbursement will be submitted using the Contractor Expenditure Report (CER) provided to the contractor by ABRC.

Costs will be reimbursed up to the maximum allowable per event after deliverables have been met.

No. Description Cost

(Not to Exceed)

1 Clinical Trials Development Workshop V* $20,000.00

2 Neonatal Opioid Withdrawal Syndrome Workshop* $25,000.00

3 Research Day* $40,000.00

4 Translational Research Workshop* $17,500.00

5 Chronic Pain Conference* $30,000.00

6 The Medical Scientist Training Program Retreat* $15,500.00

7 Friday Frontiers in Biomedical Science Series* $17,500.00

8 Mini Medical School: Community Education Events* $36,670.00

9 CPAE Consortium Conference/Professional Education* $30,000.00

Total Direct Costs $232,170.00

Indirect Costs (10%) $23,217.00

Research Education Program Tucson Not to Exceed

(NTE) Total Projected Costs $255,387.00

*Items used to calculate the ten percent (10%) Indirect Costs