INTERAGENCY SERVICE AGREEMENT

(ISA) AMENDMENT

ARIZONA DEPARTMENT OF

HEALTH SERVICES

OFFICE OF PROCUREMENT

150 N. 18th Ave., Ste. #530

Phoenix, Arizona 85007

AGREEMENT No.: CTR061681 AMENDMENT No.: 1 PROCUREMENT OFFICER Delilah Gonzalez

ARIZONA BIOMEDICAL RESEARCH COMMISSION (ABRC) EDUCATIONAL INITIATIVE

Effective upon signature, it is mutually agreed that the Agreement referenced is amended as follows:

1. Pursuant to the Uniform Terms and Conditions, Provision Twelve (12), Miscellaneous, Section 12.4, the Agreement is hereby revised with the following:

1.1.The Term of Agreement is revised to July 01, 2022, through June 30, 2027.

1.2.The Price Sheet is revised and replaced to add Indirect Costs.

Revisions are in Red.

ALL OTHER PROVISIONS SHALL REMAIN IN THEIR ENTIRETY.

Contractor hereby acknowledges receipt and acceptance of above amendment and that a signed copy must be filed with the Procurement Office before the effective date.

The above referenced Contract Amendment is hereby executed this __________ day of ______________, 20______ at Phoenix, Arizona.

Signature and Date

Authorized Signatory’s Name and Title

AZ Board of Regents, on behalf of The University of Arizona Procurement Officer Signature

Contractor’s Name

1/102023

Gina Corwin

Digitally signed by Gina Corwin Date:

2023.01.12 09:13:02 -07'00'

INTERAGENCY SERVICE AGREEMENT (ISA)

ARIZONA DEPARTMENT OF

HEALTH SERVICES

150 N 18th Avenue, Suite 530 Phoenix, Arizona 85007

(602) 542-1040 Agreement No: CTR061681

PROJECT TITLE: ARIZONA BIOMEDICAL RESEARCH COMMISSION (ABRC)

EDUCATIONAL INITIATIVE

Effective Date:

July 1, 2022

GEOGRAPHIC SERVICE AREA: STATEWIDE Termination Date:

June 30, 2027

Arizona Department of Health Services has authority to contract for services specified herein in accordance with A.R.S. § 35-148, § 36-104, and § 36-132. The University represents that it has authority to contract for the performance of the services provided herein pursuant to A.R.S. §35-148.

The University certifies compliance with all Federal immigration laws and regulations relating to employees and certifies its compliance with Section A.R.S. § 23-214, Subsection A.

The University agrees to perform all the services set forth in the Agreement and Work Statement. Amendments signed by each of the parties and attached hereto are hereby adopted by reference as a part of this Agreement, from the effective date of the Amendment, as if fully set out herein.

Arizona Transaction (Sales Privilege Tax License): For Clarification, contact:

Name: Marcel Villalobos, Assistant Director Postaward Services

Federal Employer Identification Number: Phone: (520) 626-6000

E-mail: sponsor@arizona.edu

Arizona Board of Regents, on behalf of

The University of Arizona

Contractor Signature of Person Authorized to Sign Date

845 N. Park Avenue, Room 538 Elisha Johnson, JD

Address Printed Name

Tucson Arizona 85721-0158 Director of Clinical Trials & Contracting

City State ZIP Code Title

This Agreement shall henceforth be referred to as Agreement No. CTR061681 The University is hereby cautioned not to commence any billable work or provide any material, service or construction under this Agreement until University receives an executed purchase order or Agreement release document or written notice to proceed if applicable.

State of Arizona Awarded this _____ day of ______________, 202__

Chief Procurement Officer

CONTRACT NUMBER INTERAGENCY SERVICE AGREEMENT

UNIFORM TERMS AND CONDITIONS CTR061681

In accordance with Arizona Revised Statutes (A.R.S.) Section § 35-148, this Agreement is entered into by and between the Arizona Department of Health Services (hereinafter ADHS) and the Arizona Board of Regents, University of Arizona (hereinafter University) and shall be effective as indicated in Provision 1.

For and in consideration of the terms and conditions set forth herein, the parties agree as follows:

1. Term of Agreement

This Agreement will be effective on July 1, 2022 and shall terminate on June 30, 2027, unless otherwise terminated pursuant to the terms herein. The term of this Agreement shall not exceed five (5) years.

2. Renewal of Agreement

If the term of the original Agreement is less than five (5) years, the parties may mutually agree to renew the Agreement by signing an Amendment extending the Agreement. This Agreement can be renewed for four (4) additional one-year terms, upon agreement of the University and ADHS and by both parties signing an Amendment extending this Agreement. The original Agreement term together with the renewal period shall not exceed five (5) years.

3. Compliance with A.R.S. 35-148

ADHS shall provide for reimbursement for services performed or advancement of funds for services to be performed.

Monies received by University shall be credited to its appropriation account for its use in performing the services.

University shall make an accounting of expenditures and return any advanced funds not used to ADHS.

4. Capital Equipment

In the event the parties have determined the Scope of Services requires the acquisition of capital equipment necessary for the business functions of the University and have further determined to amortize the cost of such equipment over several years, the University shall reimburse ADHS for such unamortized amounts upon a determination by the University not to renew the agreement.

5. Scope of Services

The Arizona Department of Health Services (ADHS), Arizona Biomedical Research Centre (ABRC) is an educational partner for the Arizona Researchers. The ABRC Educational Program brings high quality educational and training resources to local researchers to support them in becoming successful and nationally recognized researchers. The Research Education Program partners with local universities to support local researchers and clinical professionals by bringing national and local experts together to cover emerging topics at little or no cost to the Arizona research community.

6. Payment for Services

As payment for full and satisfactory performance of the services, the ADHS agrees to pay the University as outlined in the Price Sheet attached hereto and incorporated herein by this reference. The Master Blank Purchase Order (Agreement) will be entered into the State of Arizona e-procurement system, APP, by ADHS. The Price Sheet will be entered into the Items Tab for the creation of Purchase Order Releases.

7. Non-Availability of Funds

7.1 Every payment and service obligation is conditioned upon the availability of funds appropriated or allocated for the payment or support of such obligation. If funds are not allocated and available for the continuance of this Agreement, either ADHS or the University may terminate at the end of the period for which funds are available.

7.2 No liability shall accrue to ADHS or the University, in the event this provision is exercised, and ADHS and the

University shall not be obligated or liable for any damages as a result of termination under this paragraph.

8. Property of the State

8.1. Equipment. Except as provided below or otherwise agreed to by the parties, the title to any and all equipment acquired through the expenditure of funds received from the State shall remain the property of the State by and through the ADHS and, as such, shall remain under the sole direction, management and control of the ADHS. When this Agreement is terminated, the disposition of all such property shall be determined by the ADHS. For Fixed Price agreements, when the University provides the services/materials required by the Agreement, any and all equipment purchased by the University remains the property of the University. All purchases of equipment need to be reported to the ADHS Office of Inventory Control.

8.2. Title and Rights to Materials. It is the intention of ADHS and University that all material and intellectual property developed under this Agreement be used and controlled in ways to produce the greatest benefit to the parties to this Agreement and the citizens of the State of Arizona. As used in this paragraph, “Material” means all written and electronic information, recordings, reports, findings, research information, abstracts, results, software, data, discoveries, inventions, procedures and processes of services developed by the University and any other materials created, prepared or received by the University and subcontractors in performance of this Agreement. “Material” as used herein shall not include any pre-existing data, information, materials, discoveries, inventions or any form of intellectual property invented, created, developed or devised by University (or its employees, subcontractors or agents) prior to the commencement of the services funded by this Agreement or that may result from University’s involvement in other service activities that are not funded by the Agreement.

8.3. Title and exclusive copyright to all Material shall vest in the State of Arizona, subject to any rights reserved on behalf of the federal government. As State agencies and instrumentalities, both ADHS and University shall have full, complete, perpetual, irrevocable and non-transferable rights to reproduce, duplicate, adapt, make derivative works, distribute, display, disclose, publish and otherwise use any and all Material. The University’s right to use Material shall include the following rights: the right to use the Material in connection with its internal, non-profit research and educational activities, the right to present at academic or professional meetings or symposia and the right to publish in journals, theses, dissertations or otherwise of University’s own choosing. University agrees to provide ADHS with a right of review prior to any publication or public presentation of the Material, and ADHS shall be entitled to request the removal of its confidential information or any other content the disclosure of which would be contrary to the best interest of the State of Arizona. Neither party shall release confidential information to the public without the prior expressly written permission of the other, unless required by the State public records statutes or other law, including a court order. Each party agrees to give recognition to the other party in all public presentations or publications of any Material, when releasing or publishing them.

8.4. In addition, ADHS and University agree that any and all Material shall be made freely available to the public to the extent it is in the best interest of the State. However, if either party wants to license or assign an intellectual property interest in the material to a third-party for monetary compensation, ADHS and University agree to convene to determine the relevant issues of title, copyright, patent and distribution of revenue. In the event of a controversy as to whether the Material is being used for monetary compensation or in a way that interferes with the best interest of the state or ADHS, then the Arizona Department of Administration shall make the final decision. Notwithstanding the above, “monetary compensation’ does not include compensation paid to an individual creator for traditional publications in academia (the copyrights to which are Employee-Excluded Works under ABOR Intellectual Property Policy Section 6-908C.4.), an honorarium or other reimbursement of expenses for an academic or professional presentation, or an unprofitable distribution of Material.

9. Reports and Records

Each party shall establish and maintain records regarding its performance under this Agreement in accordance with the records retention standards established by the Department of Library and Archives. Any subcontractors shall be contractually required to retain all data and other records relating to the acquisition and performance of this Agreement for a period of five years after the completion of the Agreement as required by A.R.S. 35-214 and 35-215. All records shall be subject to inspection and audit by the State of Arizona (State) at reasonable times.

10. Termination

Either party may terminate this Agreement upon sixty (60) working days written notice to the other party. The University shall reimburse ADHS for any advanced funds for which services are not provided and shall reimburse ADHS for any other resources/materials that are specifically acquired by University, without an agreement between the parties for University to purchase the resource/material.

11. Cancellation for Conflict of Interest

Pursuant to A.R.S. § 38-511, the State, its political subdivisions or any department or agency of either may, within three years after its execution, cancel any Agreement, without penalty or further obligation, made by the State, its political subdivisions, or any of the departments or agencies of either if any person significantly involved in initiating, negotiating, securing, drafting or creating the Agreement on behalf of the State, its political subdivisions or any of the departments or agencies of either is, at any time while the Agreement or any extension of the Agreement is in effect, an employee or agent of any other party to the Agreement in any capacity or a consultant to any other party of the Agreement with respect to the subject matter of the Agreement. A cancellation made pursuant to this provision shall be effective when the University or ADHS receives written notice of the cancellation, unless the notice specifies a later time.

12. Miscellaneous

12.1. In the event of a dispute, the parties agree to use arbitration to the extent required by A.R.S. § 12-1518. The laws of the State shall govern any interpretation of this Agreement and venue shall be in Maricopa County, Arizona.

12.2. The University shall comply with State Executive Order No. 2009-09 and all other applicable Federal and

State laws, rules and regulations, including the Americans with Disabilities Act. All parties shall take affirmative action to ensure that applicants for employment and employees are not discriminated against due to race, creed, color, religion, sex, national origin or disability.

12.3. This Agreement shall be governed and interpreted by the laws of the State of Arizona.

12.4. Any amendments to this Agreement must be in writing and signed by both parties.

12.5. The provisions of this Agreement are severable. Any term or condition deemed illegal or invalid shall not affect any other term or condition of the Agreement.

12.6. This Agreement is intended by the parties as a final and complete expression of their agreement. No course of prior dealings between the parties and no usage of the trade shall supplement or explain any terms used in this Agreement.

12.7. Either party’s failure to insist on strict performance of any term or condition of the Agreement shall not be deemed a waiver of that term or condition even if the party accepting or acquiescing in the nonconforming performance knows of the nature of the performance and fails to object to it.

13. Federal Immigration and Nationality Act

The University shall comply with all federal, state and local immigration laws and regulations relating to the immigration status of their employees during the term of the Agreement. Further, the University shall flow down this requirement to all subcontractors utilized during the term of the Agreement. The State shall retain the right to perform random audits of University and subcontractor records or to inspect papers of any employee thereof to ensure compliance.

Should the State determine that the University and/or any subcontractors be found noncompliant, the State may pursue all remedies allowed by law, including, but not limited to; suspension of work, termination of the Agreement for default and suspension and/or debarment of the University.

14. E-Verify Requirements

In accordance with A.R.S. § 41-4401, University certifies compliance with all Federal immigration laws and regulations relating to employees and certifies its compliance with Section A.R.S. § 23-214, Subsection A.

15. Offshore Performance of Work Prohibited

Any services that are described in the specifications or scope of work that directly serve the State of Arizona or its clients and involve access to secure or sensitive data or personal client data shall be performed within the defined territories of the United States. Unless specifically stated otherwise in the specifications, this paragraph does not apply to indirect or overhead services, redundant back-up services or services that are incidental to the performance of the contract. This provision applies to work performed by subcontractors at all tiers.

SPECIAL TERMS AND CONDITIONS CTR061681

1. Purpose

Pursuant to provisions of the Arizona Procurement Code, A.R.S. 41-2501 Et Seq., the State of Arizona, Department of Health Services (ADHS) intends to establish an Agreement for the materials or services as listed herein.

2. Agreement Type

The Agreement shall be cost reimbursement. Indirect costs are limited to 10% of the direct costs

3. Key Personnel

It is essential that the University train and provide adequate, experienced personnel, capable of and devoted to the successful accomplishment of projects that may be performed under this Agreement. The University must agree to assign experienced individuals to project positions.

3.1. The University agrees that, once assigned to work on a project under this Agreement, key personnel should not be removed or replaced without written notice to the ADHS Project Manager.

3.2. If key personnel are not available for work on a specific project, for a continuous period exceeding thirty (30) calendar days, or are expected to devote substantially less effort to the work than initially anticipated, the University shall immediately notify the ADHS Project Manager and shall, subject to the concurrence of the ADHS, replace such personnel with personnel of substantially equal ability and qualifications.

4. Health Insurance Portability and Accountability Act (HIPAA) of 1996

4.1. The University certifies that it is familiar with the requirements of HIPAA, as amended by the Health Information

Technology for Economic and Clinical Health Act (HITECH Act) of 2009, and accompanying regulations and will comply with all applicable HIPAA requirements in the course of this Agreement. University certifies that it will cooperate with the Arizona Department of Health Services (ADHS) in the course of performance of the Agreement so that both ADHS and University will be in compliance with HIPAA, including cooperation and coordination with the Arizona Department of Administration-Arizona Strategic Enterprise Technology (ADOA- ASET) Office, the ADOA-ASET Arizona State Chief Information Security Officer and HIPAA Coordinator and other compliance officials required by HIPAA and its regulations. University will sign any documents that are reasonably necessary to keep ADHS and University in compliance with HIPAA, including, but not limited to, business associate agreements.

4.2. If requested by the ADHS Procurement Office, University agrees to sign a “Pledge To Protect Confidential Information” and to abide by the statements addressing the creation, use and disclosure of confidential information, including information designated as protected health information and all other confidential or sensitive information as defined in policy. In addition, if requested, University agrees to attend or participate in HIPAA training offered by ADHS or to provide written verification that the University has attended or participated in job related HIPAA training that is: (1) intended to make the University proficient in HIPAA for purposes of performing the services required and (2) presented by a HIPAA Privacy Officer or other person or program knowledgeable and experienced in HIPAA and who has been approved by the ADOA-ASET Arizona State Chief Information Security Officer and HIPAA Coordinator.

5. Authorization for Provision of Services

Authorization for purchase of services under this Agreement shall be made only upon ADHS issuance of a Purchase Order that is signed by an authorized agent. The Purchase Order will indicate the Agreement number and the dollar amount of funds authorized. The University shall only be authorized to perform services up to the amount on the Purchase Order. ADHS shall not have any legal obligation to pay for services in excess of the amount indicated on the Purchase Order. No further obligation for payment shall exist on behalf of ADHS unless a) the Purchase Order is changed or modified with an official ADHS Procurement Change Order, and/or b) an additional Purchase Order is issued for purchase of services under this Agreement.

6. Price Adjustment

University prices accepted and subsequently awarded by an Agreement shall remain in effect for a minimum of one

(1) year. The University may request a price adjustment, but the State will not review or approve an increase until the Agreement has been in effect for one (1) year. The ADHS Procurement Office will review any requested rate increase to determine whether such request is reasonable in relation to increased supplier or material costs. University shall provide written justification for any price adjustment requested. Any price increase adjustment, if approved, will be effective upon execution of a written Agreement amendment. Likewise, the University shall offer the State a price adjustment reduction concurrent with reduced costs from their suppliers. Price reductions will become effective upon execution of an Agreement amendment.

7. Pandemic Contractual Performance

7.1. The State shall require a written plan that illustrates how the University shall perform up to contractual standards in the event of a pandemic. The State may require a copy of the plan at anytime prior or post award of an Agreement. At a minimum, the pandemic performance plan shall include:

7.1.1. Key succession and performance planning if there is a sudden significant decrease in University’s workforce.

7.1.2. Alternative methods to ensure there are products in the supply chain.

7.1.3. An up to date list of company contacts and organizational chart.

7.2. In the event of a pandemic, as declared the Governor of Arizona, U.S. Government or the World Health Organization, which makes performance of any term under this Agreement impossible or impracticable, the State shall have the following rights:

7.2.1. After the official declaration of a pandemic, the State may temporarily void the Agreement(s) in whole or specific sections, if the University cannot perform to the standards agreed upon in the initial terms.

7.2.2. The State shall not incur any liability if a pandemic is declared and emergency procurements are authorized by the Director as per A.R.S. 41-2537 of the Arizona Procurement Code.

7.2.3. Once the pandemic is officially declared over and/or the University can demonstrate the ability to perform, the State, at is sole discretion, may reinstate the temporarily voided Agreement(s).

7.3. The State, at any time, may request to see a copy of the written plan from the University. The Contactor shall produce the written plan within seventy-two (72) hours of the request.

8. Compliance Requirements for A.R.S. § 41-4401, Government Procurement: E-Verify Requirement

8.1. The University certifies compliance with all Federal immigration laws and regulations relating to employees and certifies its compliance with Section A.R.S. § 23-214, Subsection A. (That subsection reads: “After December 31, 2007, every employer, after hiring an employee, shall verify the employment eligibility of the employee through the E-Verify program.)

8.2. A breach of a certification regarding compliance with immigration laws and regulations shall be deemed a material breach of the Contract and the University may be subject to penalties up to and including termination of the Contract.

8.3. Failure to comply with a State audit process to randomly verify the employment records of the University’s and subcontractors shall be deemed a material breach of the Contract and the University may be subject to penalties up to and including termination of the Contract.

8.4. The State Agency retains the legal right to inspect the papers of any employee who works on the Contract to ensure that the University or subcontractor is complying with the certification under paragraph 1.

9. Advance Funds

A.R.S. § 35-148 (A) authorizes a State Agency to advance funds to another State Agency for services to be performed pursuant to an Interagency Service Agreement, and (B) authorizes such funds to be credited to the appropriation account of the Agency performing the services for use by such Agency.

10. Disputes

Any dispute that develops over an issue in regard to the performance or failure to perform under the terms of this Agreement shall be resolved by the Director of Arizona Department of Health Services and the University Board of Regents or by the Governor if the respective parties cannot resolve the issue.

11. Funds

Funds may not presently be available for performance under this Agreement beyond the current fiscal year. No legal liability on the part of the State for any payment may arise under this Agreement beyond the current fiscal year until funds are made available for performance of this Agreement. The State shall make reasonable efforts to secure such funds.

12. Indirect Rate

The University agrees that for any project requested by ADHS that is funded by State appropriated or other type of State funding, the University shall charge an Indirect Rate no greater than ten percent (10%).

13. The Federal Funding Accountability and Transparency Act (FFATA or Transparency Act - P.L.109-282, as amended by section 6202(a) of P.L. 110-252), found at https://www.fsrs.gov/

If applicable, the Contractor/Grantee shall submit to ADHS via email the Grant Reporting Certification Form. This form and the instructions can be downloaded from the ADHS Procurement website at http://www.azdhs.gov/operations/financial-services/procurement/index.php#ffata and must be returned to the ADHS by the 15th of the month following that in which the award was received. The form shall be completed electronically, and submitted using the steps outlined in the Grant Reporting Certification Form Instructions to the following email address: ADHS_Grant@azdhs.gov. All required fields must be filled including Top Employee Compensation, if applicable. Completing the Grant Reporting Certification Form is required for compliance with the Office of Management and Budget (OMB), found at http://www.whitehouse.gov/omb/open. Failure to timely submit the Grant Reporting Certification Form could result in the loss of funds. This requirement applies to all subcontractors/sub-awardees utilized by the Contractor/Grantee for amounts exceeding $30,000.00 during the term of the Award.

14. Contracting; Procurement; Investment; Prohibitions

14.1. A public entity may not enter into a contract with a company to acquire or dispose of services, supplies, information technology or construction unless the contract includes a written certification that the company is not currently engaged in, and agrees for the duration of the contract to not engage in, a boycott of Israel.

14.2. A public entity may not adopt a procurement, investment or other policy that has the effect of inducing or requiring a person or company to boycott Israel.

15. Technology Replacement

In any event where product is discontinued, no longer available or technically inferior to newly developed product, the University shall provide an equivalent replacement model at no additional cost and shall honor the original contract terms.

SCOPE OF SERVICES CTR061681

1. Background The Arizona Department of Health Services (ADHS), Arizona Biomedical Research Centre (ABRC) is an educational partner for the Arizona Researchers. The ABRC Educational Program brings high quality educational and training resources to local researchers to support them in becoming successful and nationally recognized researchers. The Research Education Program partners with local universities to support local researchers and clinical professionals by bringing national and local experts together to cover emerging topics at little or no cost to the Arizona research community.

2. Objective

The objective of this Agreement is to work with the University of Arizona, Tucson, in order to organize a series of workshops and other educational activities in the Tucson area for the University, hospital researchers, and community members.

3. Tasks

The University shall:

3.1. Partner collaboratively whenever possible with identified organizations to fulfill this mission on behalf of the

ADHS ABRC;

3.2. Design and implement each of the workshops in collaboration with relevant community partners and multidisciplinary units within the University;

3.3. Make workshops open to the general public, with special emphasis on university, hospital, community health center, other community based public health-oriented institutions;

3.4. Provide workshops free of charge to participants;

3.5. Provide distance learning/participation opportunities for all events during pandemics or other times when physical gatherings are restricted;

3.6. Include the ABRC Program Director in event planning committees; and

3.7. Fund, create and host the following events on behalf of the ABRC Research Education Program:

3.7.1. Clinical Trials Development Workshop IV (Led by Rachna Schroff, MD, Associate Professor of

Medicine and Associate Dean for Clinical and Translational Research). This workshop follows the highly successful Clinical Trials Development workshop that took place in April, 2019 and June 2022.

This workshop will delve deeper into specific aspects of clinical trial design, tips for successful mentoring relationships, and is aimed and developing proposals for clinical trials. It will be marketed to attendees of the prior workshops (feedback from which indicated a deeper dive into some of these topics) in addition to a broader audience including researchers and clinicians from institutions across Southern Arizona.

3.7.1.1. Examples of topics include participant selection and retention, writing Institutional Review

Board (IRB) protocols, conflict of interest, and research project management;

3.7.1.2. One (1) half-day Workshop;

3.7.1.3. Target attendance at a minimum of fifty (50) participants; and

3.7.1.4. The College of Medicine – Tucson shall:

3.7.1.4.1. Advertise the event and encourage broad participation statewide, and

3.7.1.4.2. Submit to ABRC via Box, event photos, which may be used by ABRC for promotional and reporting purposes; a summary of the event, event materials and participant feedback.

3.7.2. Innovations and Inventions (Led by Jason Wertheim, MD, PhD, Vice-Dean for Scientific Initiatives;

Anne Cress, PhD, Deputy Dean for Research; and Carol C. Gregorio, PhD, Head of Cellular & Molecular Medicine). This event will have an in-person plan with a potential for a virtual event. This will turn into an annual, presentation-based event with a five (5) minute “data blitz” format from newly hired faculty focused on emerging, state-of-the-art research innovations. (Note: the last event was only made possible because of funds from the ABRC.) Presentations will occur on a wide-screen display.

Between 30-40 poster presentations of innovative biomedical science projects and devices will occur immediately after the platform sessions. Networking opportunities for all participants will be scheduled both before and after the presentations. Networking will include participation by representatives from Tech Launch Arizona and UA Research Core Facilities.

3.7.2.1. Event will be One (1) three (3) hour conference for biomedical researchers and the

Community;

3.7.2.2. Target attendance at a minimum of 200 participants;

3.7.2.3. The College of Medicine – Tucson shall:

3.7.2.3.1. Form a planning committee specific to this event,

3.7.2.3.2. Advertise the event and encourage broad participation state-wide to include the community and industry, and

3.7.2.3.3. Submit to ABRC via Box, event photos, which may be used by ABRC for promotional and reporting purposes, a summary of the event, event materials

3.7.3. Research Day (led by Jason Wertheim, MD, PhD, Vice-Dean for Scientific Initiatives; Anne Cress, PhD, Deputy Dean for Research; Carol Gregorio, PhD, Head of Cellular & Molecular Medicine). This will be the fourth 4th annual, day-long event organized to spur interdisciplinary research collaboration between basic scientists and clinicians. (Note: the inaugural event was only made possible because of funds from the ABRC.) The event will feature keynote talks from experts in translational research, data blitzes, demonstrations, and a ‘shark tank’ type competition. More than 100 researchers will share their unique projects, and (3) three TEDx-style talks [two (2) external speakers and one (1) internal speaker (i.e., COVID-19 research was a focus in 2021) will expose attendees to the frontiers of innovative biomedical research. The event will close with a select group of physicians and researchers demonstrating their medical expertise and innovations.

3.7.3.1. The event will be One (1) day-long event;

3.7.3.2. Target attendance at a minimum of 500 hundred participants;

3.7.3.3. Invitees shall include biomedical researchers across Arizona, students, and the community;

3.7.3.4. The College of Medicine – Tucson shall:

3.7.3.4.1. Form a planning committee specific to this symposium,

3.7.3.4.2. Advertise the event and encourage broad participation state-wide to include the community and industry, and

3.7.3.4.3. Submit to ABRC via Box, event photos, which may be used by ABRC for

3.7.4. Translational Research Workshop (Led by Julie Ledford, PhD, Associate Professor of Cellular & Molecular Medicine). This full day workshop will demystify translational research and help both basic and clinical scientists enter into bench-to-bedside research collaborations that could lead to new interventions, medical devices, diagnostics and therapeutics. It will be marketed to all biomedical research constituencies, with a special emphasis on junior faculty, post-docs, clinical fellows, graduate students and upper division undergraduate students. Content will include: how to translate a basic science study into the clinic, working with industry partners, intellectual property and patent issues, the patient’s perspective, Phase I trials and more. Two (2) keynote speakers who have successfully translated a discovery in their laboratory to a treatment that is currently being used in the clinic will be invited to share their knowledge and experiences into the clinic to support hematopoietic stem and progenitor cell (HSPC) engraftments and prevent graft-versus-host disease, a major complication of otherwise life-saving stem cell transplants. Significant and innovative topics in biomedicine shall be determined based on the planning committee, which includes representatives from ABRC and potential stakeholders.

3.7.4.1. Event will be One (1) half-day event for biomedical researchers;

3.7.4.2. Target attendance at a minimum of fifty (50) participants;

3.7.4.3. Invitees shall include biomedical researchers across Arizona including junior faculty, post-doctoral and clinical fellows, residents and graduate students;

3.7.4.4. The College of Medicine – Tucson shall:

3.7.4.4.1. Form a planning committee specific to this workshop, and

3.7.4.4.2. Advertise the event and encourage broad participation state-wide to include researchers from Arizona State University (ASU), Northern Arizona University (NAU), Translational Genomic Research Institute (TGen), and other Arizona biomedical research institutions;

3.7.5. Chronic Pain and the Opioid Crisis: Perception and Reality Conference (led by Todd Vanderah, PhD, Professor and Head, Department of Pharmacology and Director, UArizona Comprehensive Pain and Addiction Center). The significant public health crisis and individual burden of pain has received increasing recognition, especially in Arizona. The crisis highlights the challenges the pain field faces as it tries to develop better treatment and management strategies for patients and health professionals, and has led to the establishment of the UArizona Comprehensive Pain and Addiction Center in March 2020. A full-day conference will be organized to bring together scientists, physicians, patients, the pharmaceutical industry, and government officials to address critical questions for the field.

Internationally recognized scientists, pain physicians, patients, government officials, and members of the FDA and NIH as speakers will be engaged. Include open slots for late-breaking talks to highlight new cutting-edge discoveries that we anticipate will be made over the next six to nine (6-9) months, this includes novel Intellectual Property on a highly potent and long-lasting opioid antagonist to prevent and reverse fentanyl and carfentanyl overdoses - heavily emphasizing young investigators (postdoctoral fellows and graduate student trainees and new junior faculty), women and under-represented groups will be engaged. Include Invitation of rural health care partners in our paraprofessional training program for substance use disorder. Topics will include: 1) What is the link between pain and opioid addiction? 2) What can be done to enhance the range of medication options to treat opioid use disorders (OUD) and prevent/reverse overdoses? 3) How do we develop new non-addictive medications for pain relief? Activities will include poster sessions (with emphasis to include undergraduate and graduate students, as well as postdoctoral fellows).

3.7.5.1. This event will be one (1) full day-long event;

3.7.5.2. Target attendance at a minimum of 200 participants; and

3.7.5.3. The College of Medicine – Tucson shall:

3.7.5.3.1. Form a planning committee specific to this symposium,

3.7.5.3.2. Advertise the conference and encourage broad participation state-wide, and

3.7.5.3.3. Submit to ABRC via Box, event photos, which may be used by ABRC for

3.7.6. The Medical Scientist Training Program (MSTP) Retreat (led by Todd Vanderah, PhD, Professor and Head, Department of Pharmacology, George Fantry, MD, Associate Dean for Student Affairs and Admissions, Jason Wertheim, MD, PhD Vice-Dean for Scientific Initiatives). The University of Arizona College of Medicine (UACOM) Doctorate of Medicine and Philosophy (MD-PhD) retreat aims to welcome new students as well as provide a space for current students and faculty to network and present their progress in research and medicine. UA College of Medicine - Tucson (COM-T) has been awarded the National Institute of Health Medical Scientist Training Program (MSTP T32) grant as of July 1, 2021 and will be the only MSTP T32 in the state of Arizona. As such, this is an excellent opportunity to enroll and train students across the entire state. Format for presentations will be data blitz style and the event will open with a keynote address. The first (1st) retreat was held in the Summer of 2021 and will be continued annually thereafter. In-line with national trends for MD-PhD training this retreat with serve as a foundation for building collaborations within our program and the greater Arizona community. We will include multi-disciplinary sessions on focusing biomedical ethics, wellness/burnout, career development, scientific mentoring, ethics, grant writing and discussions centered around how to choose a laboratory research and summer rotations. It is to be marketed to all MD/PhD students at the University of Arizona College of Medicine Tucson and Phoenix Campuses, all program directors and both institutions, MTSP faculty mentors, and member of the University of Arizona Health Sciences Leadership. Trainees from UA-COM Tucson and Phoenix will be invited, and research collaborators will be invited from across the state, including ASU, NAU, and University of Arizona Health Sciences (UAHS).

3.7.6.1. The event will be a one (1) day long event for MD/PhD researchers at the University of

Arizona College of Medicine Tucson and Phoenix,

3.7.6.2. Target attendance at a minimum of fifty (50) participants, and

3.7.6.3. Submit to ABRC via Box, event photos, which may be used by ABRC for promotional and reporting purposes, a summary of the event, event materials and participant feedback.

3.7.7. Friday Frontiers in Biomedical Science Series (led by Jason Wertheim, MD, PhD, Vice-Dean for

Scientific Initiatives; Anne Cress, PhD, Deputy Dean for Research; and Rachna T. Shroff, MD, Associate Dean for Clinical and Translational Research). Each session feature two (2) speakers who will each share twenty (20) -minute data blitzes of a basic and clinical sciences research team targeted at a lay audience to engage community experts and academic scientists at all stages of career development to promote discussion and hypothesis generating ideas and projects. Event will be open to all UA students and faculty Topics will range from immunologic approaches to cancer therapy, mental health impact of COVID-19 isolation on elderly populations, resilience in the nursing workforce.

The event will include informal discussions of participants with the team during a light appetizer hour.

Occurs first (1st) Friday of every month throughout the academic year.

3.7.7.1. This series will be nine (9) events;

3.7.7.2. Target attendance at a minimum of fifty (50) participants per event; and

3.7.7.3. The College of Medicine – Tucson shall:

3.7.7.3.1. Form a planning committee specific for these events and keep ABRC informed;

3.7.7.3.2. Advertise the event and encourage broad participation state-wide; and

3.7.7.3.3. Submit to ABRC via Box, event photos, which may be used by ABRC for

3.7.8. Community Education Events: Biomedical News to Use (led by Jason Wertheim, MD, PhD, Vice- Dean for Scientific Initiatives; Anne E. Cress, PhD, Senior Associate Dean for Research; Rachna T.

Shroff, MD, Associate Dean for Clinical and Translational Research; and Joshua Lee, MD, Physician Executive, Banner University Medicine Tucson). Education series in a Ted-style format to engage/provide useful information to communities in targeted health areas. These will be publicized and broadcast widely and will involve partnering with community leaders in Southern Arizona, the Veteran Affairs (VA) hospitals in Arizona, and throughout the state. Topics will include health disparities and differential access to biomedical care, biomedical partnerships across underrepresented populations, hot topics in Arizona public health policy, veterans’ health. Presentations will be video enhanced and archived for enduring use.

3.7.8.1. This series will consist of five (5) half-day events;

3.7.8.2. Target audience at a minimum of fifty (50) participants per seminar, specifically targeting a community audience across the state; and

3.7.8.3. The College of Medicine – Tucson shall:

3.7.8.3.1. Form a planning committee specific developing content for these community education events and include ABRC staff,

3.7.8.3.2. Advertise the event and encourage broad participation state-wide, and

3.7.8.3.3. Submit to ABRC via Box, event photos, which may be used by ABRC for

3.7.9. Children’s Postinfectious Autoimmune Encephalopathy (CPAE) Consortium Conference/

Professional Education. The Children’s Postinfectious Autoimmune Encephalopathy Center of Excellence at the University of Arizona Steele Children's Research Center (UA CPAE) has developed strong ties with researchers and centers throughout the United States (US) involved in researching and treating this condition. UA CPAE will coordinate four (4) consortium conferences where the physician-researchers can share their work and collaborate. Two (2) for the CPAE Consortium and two

(2) for Professional Education. The conferences will be conducted either on-line or in-person, based on travel viability and participant preferences. Following each conference, a report will be prepared documenting the conference proceedings, to include a compendium of current research projects.

3.7.9.1. This series will be a full day event each time;

3.7.9.2. Target audience: Twenty-five (25) to fifty (50) participants per seminar; and

3.7.9.3. The CPAE Center of Excellence at UA CPAE shall:

3.7.9.3.1. Form a planning committee specific to developing content for the Consortium Conferences and keep ABRC informed,

3.7.9.3.2. Advertise the event and encourage broad participation state-wide, and

3.7.9.3.3. Submit to ABRC via Box, event photos, which may be used by ABRC for

4. Deliverables

4.1. No less than thirty (30) days prior to the event, the University shall submit the agenda and budget to biomedical@azdhs.gov for review and approval;

4.2. Due thirty (30) days after each event, the University shall provide the following:

4.2.1. A report to include:

4.2.1.1. Subject covered;

4.2.1.2. Narrative of the event;

4.2.1.3. Objectives of the event;

4.2.1.4. Number of participants;

4.2.1.5. Background of participants (e.g. researcher, public, scientist);

4.2.1.6. Participating organizations; and

4.2.1.7. Outcome/Results.

4.2.2. CD (or cloud type file upload/download service, e.g. Box) of the event, to include the following:

4.2.2.1. Event program/agenda;

4.2.2.2. Event photos, which may be used by ABRC for promotional and reporting purposes; and

4.2.2.3. Speaker posters and presentations, with their approval.

5. Exclusions and Limitations

5.1. Events that the school would host without this support are not eligible;

5.2. Credit-based or paid coursework are not allowed;

5.3. Participants cannot be charged without prior ABRC approval which will be considered on a case-by-case basis; and

5.4. Meals can only be provided with this funding if the event is longer than six (6) hours. Refreshments for shorter events should be limited to less than ten dollars ($10) per person per event.

6. Notices, Correspondence, Reports, Invoices and Payments

6.1. Notices, correspondence and reports from the University to ADHS shall be sent to:

John Garcia Program Director

Arizona Department of Health Services 250 N. 17th Avenue, Suite 1219 Phoenix, AZ 85007 Telephone: (602) 364-3128 Email: biomedical@azdhs.gov

6.2. Notices and correspondence from ADHS to the University shall be sent to:

Paul Sandoval Director The University of Arizona 888 N. Euclid Avenue Room 510 Tucson, AZ 85719-0521

6.3. Payments from ADHS to the University shall be sent to: (University to complete)

The University of Arizona Sponsored Projects & Contracting Services PO Box 41867 Tucson, AZ 85717

6.4. CERs shall be submitted to: biomedical@azdhs.com

PRICE SHEET CTR061681

Effective July 1, 2022 to June 30, 2023

Reimbursement will be submitted using the Contractor Expenditure Report (CER) provided to the contractor by ABRC.

Costs will be reimbursed up to the maximum allowable per event after deliverables have been met.

Description

Cost (Not to Exceed)

1 Clinical Trials Development Workshop IV $19,500.00

2 Innovations and Inventions $27,500.00

3 Research Day $38,000.00

4 Translational Research Workshop $17,500.00

5 Chronic Pain Conference $30,000.00

6 The Medical Scientist Training Program Retreat $15,500.00

7 Friday Frontiers in Biomedical Science Series $17,500.00

8 Community Education Events: Biomedical News to Use $17,500.00

9 CPAE Consortium Conference/Professional Education $30,000.00

Total Direct Costs $213,000.00

Indirect Costs $21,300.00

Total Project Costs $234,300.00