36C25220Q0128-0002005.pdf

FOL Flex® reagent cartridge

Liquid.

SAFETY DATA SHEET

Product identifier

Product type

Section 1. Identification

FOL Flex® reagent cartridge

Relevant identified uses of the substance or mixture and uses advised against

DEDM0143

(800) 424-9300 (CHEMTREC) (24/365)

Manufactured/supplied : Siemens Healthcare Diagnostics Inc.

511 Benedict Avenue Tarrytown, NY 10591-5097 USA 1-877-229-3711

Product code : K6444, 10445138

Not applicable.

(2012 OSHA Hazard Communication Standard (29 CFR 1910.1200))

SDS # :

Section 2. Hazards identification

CORROSIVE TO METALS - Category 1 SKIN IRRITATION - Category 2 EYE IRRITATION - Category 2A SKIN SENSITIZATION - Category 1

Classification of the substance or mixture

Signal word : Warning

Hazard statements : H290 - May be corrosive to metals.

H319 - Causes serious eye irritation.

H315 - Causes skin irritation.

H317 - May cause an allergic skin reaction.

Hazard pictograms :

Precautionary statements

Prevention : P264 - Wash hands thoroughly after handling.

P280 - Wear protective gloves/protective clothing/eye protection/face protection.

P272 - Contaminated work clothing should not be allowed out of the workplace.

P234 - Keep only in original container.

Response : P390 - Absorb spillage to prevent material damage.

P302 + P352 + P363 - IF ON SKIN: Wash with plenty of soap and water. Wash contaminated clothing before reuse.

P333 + P313 - If skin irritation or rash occurs: Get medical attention.

P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes.

Remove contact lenses, if present and easy to do. Continue rinsing.

P337 + P313 - If eye irritation persists: Get medical attention.

Storage : Not applicable.

GHS label elements

OSHA/HCS status : This material is considered hazardous by the OSHA Hazard Communication Standard

(29 CFR 1910.1200).

Not available.

Not available.

Additional information :

Date of issue/Date of revision : 5/12/2017 Date of previous issue : 1/22/2016 Version : 1.05 1/12

Section 2. Hazards identification Disposal : P501 - Dispose of contents and container in accordance with all local, regional, and national regulations.

Hazards not otherwise classified

: None known.

Section 3. Composition/information on ingredients

(R*,R*)-(±)-1,4-dimercaptobutane-2,3-diol 6.25 27565-41-9 sodium hydroxide 1.9 1310-73-2 reaction mass of: 5-chloro-2-methyl-4-isothiazolin-3-one [EC no. 247-500-7] and 2-methyl-2H-isothiazol-3-one [EC no. 220-239-6] (3:1)

0.003 55965-84-9

Ingredient name CAS number%

There are no additional ingredients present which, within the current knowledge of the supplier and in the concentrations applicable, are classified as hazardous to health or the environment and hence require reporting in this section.

Substance/mixture :

Occupational exposure limits, if available, are listed in Section 8.

Mixture

Any concentration shown as a range is to protect confidentiality or is due to batch variation.

Wash out mouth with water. Remove dentures if any. Remove victim to fresh air and keep at rest in a position comfortable for breathing. If material has been swallowed and the exposed person is conscious, give small quantities of water to drink. Stop if the exposed person feels sick as vomiting may be dangerous. Do not induce vomiting unless directed to do so by medical personnel. If vomiting occurs, the head should be kept low so that vomit does not enter the lungs. Get medical attention if adverse health effects persist or are severe. Never give anything by mouth to an unconscious person. If unconscious, place in recovery position and get medical attention immediately. Maintain an open airway. Loosen tight clothing such as a collar, tie, belt or waistband.

Immediately flush eyes with plenty of water, occasionally lifting the upper and lower eyelids. Check for and remove any contact lenses. Continue to rinse for at least 10 minutes. Get medical attention.

Wash with plenty of soap and water. Remove contaminated clothing and shoes. Wash contaminated clothing thoroughly with water before removing it, or wear gloves.

Continue to rinse for at least 10 minutes. Get medical attention. In the event of any complaints or symptoms, avoid further exposure. Wash clothing before reuse. Clean shoes thoroughly before reuse.

Remove victim to fresh air and keep at rest in a position comfortable for breathing. If not breathing, if breathing is irregular or if respiratory arrest occurs, provide artificial respiration or oxygen by trained personnel. It may be dangerous to the person providing aid to give mouth-to-mouth resuscitation. Get medical attention if adverse health effects persist or are severe. If unconscious, place in recovery position and get medical attention immediately. Maintain an open airway. Loosen tight clothing such as a collar, tie, belt or waistband.

Section 4. First aid measures

Eye contact

Skin contact

Inhalation

Ingestion :

Description of necessary first aid measures

Most important symptoms/effects, acute and delayed

Inhalation : No known significant effects or critical hazards.

No known significant effects or critical hazards.:Ingestion

Skin contact : Causes skin irritation. May cause an allergic skin reaction.

Causes serious eye irritation.:Eye contact

Over-exposure signs/symptoms

Potential acute health effects

Date of issue/Date of revision : 5/12/2017 Date of previous issue : 1/22/2016 Version : 1.05 2/12

Section 4. First aid measures

Protection of first-aiders : No action shall be taken involving any personal risk or without suitable training. It may be dangerous to the person providing aid to give mouth-to-mouth resuscitation. Wash contaminated clothing thoroughly with water before removing it, or wear gloves.

Notes to physician : Treat symptomatically. Contact poison treatment specialist immediately if large quantities have been ingested or inhaled.

Specific treatments : No specific treatment.

Skin contact

Ingestion

Inhalation No specific data.

No specific data.

Adverse symptoms may include the following:

irritation redness

Eye contact : Adverse symptoms may include the following:

pain or irritation watering redness

See toxicological information (Section 11)

Indication of immediate medical attention and special treatment needed, if necessary

Section 5. Fire-fighting measures

Promptly isolate the scene by removing all persons from the vicinity of the incident if there is a fire. No action shall be taken involving any personal risk or without suitable training.

Hazardous thermal decomposition products

Specific hazards arising from the chemical

Decomposition products may include the following materials:

carbon dioxide carbon monoxide sulfur oxides halogenated compounds metal oxide/oxides

In a fire or if heated, a pressure increase will occur and the container may burst.

Fire-fighters should wear appropriate protective equipment and self-contained breathing apparatus (SCBA) with a full face-piece operated in positive pressure mode.

Special protective equipment for fire-fighters

Extinguishing media

None known.

Suitable extinguishing media

Unsuitable extinguishing media

Special protective actions for fire-fighters

In case of fire, use water spray (fog), foam or dry chemical.

Section 6. Accidental release measures Personal precautions, protective equipment and emergency procedures

: No action shall be taken involving any personal risk or without suitable training.

Evacuate surrounding areas. Keep unnecessary and unprotected personnel from entering. Do not touch or walk through spilled material. Avoid breathing vapor or mist.

Provide adequate ventilation. Wear appropriate respirator when ventilation is inadequate.

Put on appropriate personal protective equipment.

For non-emergency personnel

For emergency responders : If specialized clothing is required to deal with the spillage, take note of any information in Section 8 on suitable and unsuitable materials. See also the information in "For non-emergency personnel".

Date of issue/Date of revision : 5/12/2017 Date of previous issue : 1/22/2016 Version : 1.05 3/12

Section 6. Accidental release measures Environmental precautions

Stop leak if without risk. Move containers from spill area. Absorb spillage to prevent material damage. Approach release from upwind. Prevent entry into sewers, water courses, basements or confined areas. Wash spillages into an effluent treatment plant or proceed as follows. Contain and collect spillage with non-combustible, absorbent material e.g. sand, earth, vermiculite or diatomaceous earth and place in container for disposal according to local regulations (see Section 13). Dispose of via a licensed waste disposal contractor. Contaminated absorbent material may pose the same hazard as the spilled product. Note: see Section 1 for emergency contact information and Section 13 for waste disposal.

: Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains and sewers. Inform the relevant authorities if the product has caused environmental pollution (sewers, waterways, soil or air).

Large spill :

Stop leak if without risk. Move containers from spill area. Dilute with water and mop up if water-soluble. Alternatively, or if water-insoluble, absorb with an inert dry material and place in an appropriate waste disposal container. Absorb spillage to prevent material damage. Dispose of via a licensed waste disposal contractor.

Small spill :

Methods and materials for containment and cleaning up

Section 7. Handling and storage

Advice on general occupational hygiene

Conditions for safe storage, including any incompatibilities

Eating, drinking and smoking should be prohibited in areas where this material is handled, stored and processed. Workers should wash hands and face before eating, drinking and smoking. Remove contaminated clothing and protective equipment before entering eating areas. See also Section 8 for additional information on hygiene measures.

Store in accordance with local regulations. Store in original container protected from direct sunlight in a dry, cool and well-ventilated area, away from incompatible materials (see Section 10) and food and drink. Store in a corrosion resistant container with a resistant inner liner. Keep container tightly closed and sealed until ready for use.

Containers that have been opened must be carefully resealed and kept upright to prevent leakage. Do not store in unlabeled containers. Use appropriate containment to avoid environmental contamination.

Protective measures Put on appropriate personal protective equipment (see Section 8). Persons with a history of skin sensitization problems should not be employed in any process in which this product is used. Do not get in eyes or on skin or clothing. Do not ingest. Avoid breathing vapor or mist. Keep in the original container or an approved alternative made from a compatible material, kept tightly closed when not in use. Empty containers retain product residue and can be hazardous. Do not reuse container. Absorb spillage to prevent material damage.

Precautions for safe handling sodium hydroxide ACGIH TLV (United States, 3/2015).

C: 2 mg/m³ NIOSH REL (United States, 10/2013).

CEIL: 2 mg/m³ OSHA PEL (United States, 2/2013).

TWA: 2 mg/m³ 8 hours.

OSHA PEL 1989 (United States, 3/1989).

CEIL: 2 mg/m³

Section 8. Exposure controls/personal protection

Ingredient name Exposure limits

Appropriate engineering controls

: Good general ventilation should be sufficient to control worker exposure to airborne contaminants.

Control parameters

Occupational exposure limits

Date of issue/Date of revision : 5/12/2017 Date of previous issue : 1/22/2016 Version : 1.05 4/12

Section 8. Exposure controls/personal protection

Hand protection

Based on the hazard and potential for exposure, select a respirator that meets the appropriate standard or certification. Respirators must be used according to a respiratory protection program to ensure proper fitting, training, and other important aspects of use.

Chemical-resistant, impervious gloves complying with an approved standard should be worn at all times when handling chemical products if a risk assessment indicates this is necessary. Considering the parameters specified by the glove manufacturer, check during use that the gloves are still retaining their protective properties. It should be noted that the time to breakthrough for any glove material may be different for different glove manufacturers. In the case of mixtures, consisting of several substances, the protection time of the gloves cannot be accurately estimated.

Safety eyewear complying with an approved standard should be used when a risk assessment indicates this is necessary to avoid exposure to liquid splashes, mists, gases or dusts. If contact is possible, the following protection should be worn, unless the assessment indicates a higher degree of protection: chemical splash goggles.

Eye/face protection

Respiratory protection :

Body protection Personal protective equipment for the body should be selected based on the task being performed and the risks involved and should be approved by a specialist before handling this product.

Environmental exposure controls

: Emissions from ventilation or work process equipment should be checked to ensure they comply with the requirements of environmental protection legislation. In some cases, fume scrubbers, filters or engineering modifications to the process equipment will be necessary to reduce emissions to acceptable levels.

Wash hands, forearms and face thoroughly after handling chemical products, before eating, smoking and using the lavatory and at the end of the working period. Appropriate techniques should be used to remove potentially contaminated clothing. Contaminated work clothing should not be allowed out of the workplace. Wash contaminated clothing before reusing. Ensure that eyewash stations and safety showers are close to the workstation location.

Hygiene measures :

Individual protection measures

Skin protection

Other skin protection : Appropriate footwear and any additional skin protection measures should be selected based on the task being performed and the risks involved and should be approved by a specialist before handling this product.

Section 9. Physical and chemical properties Physical state

Relative density

Liquid.

Not relevant/applicable due to nature of the product.

Not relevant/applicable due to nature of the product.Odor pH

Not relevant/applicable due to nature of the product.Color

Auto-ignition temperature

Flash point

Not available.

Not available.

Not available.

Not available.

Viscosity Not available.

Partition coefficient: n-octanol/water

Flammability (solid, gas) : Not relevant/applicable due to nature of the product.

Solubility in water : Not relevant/applicable due to nature of the product.

Section 10. Stability and reactivity

The product is stable.Chemical stability :

Possibility of hazardous reactions

: Under normal conditions of storage and use, hazardous reactions will not occur.

Reactivity : No specific test data related to reactivity available for this product or its ingredients.

Date of issue/Date of revision : 5/12/2017 Date of previous issue : 1/22/2016 Version : 1.05 5/12

Section 10. Stability and reactivity

Hazardous decomposition products

Conditions to avoid No specific data.

Under normal conditions of storage and use, hazardous decomposition products should not be produced.

Reactive or incompatible with the following materials:

metals

Incompatible materials :

Section 11. Toxicological information

Acute toxicity reaction mass of: 5-chloro- 2-methyl-4-isothiazolin-3-one [EC no. 247-500-7] and 2-methyl-2H-isothiazol-3-one [EC no. 220-239-6] (3:1)

LD50 Oral Rat 53 mg/kg -

Product/ingredient name Result Species Dose Exposure

Carcinogenicity

Not available.

Mutagenicity

Not available.

Teratogenicity

Not available.

Reproductive toxicity

Not available.

Irritation/Corrosion sodium hydroxide Eyes - Severe irritant Monkey - 24 hours 1 Percent

Eyes - Mild irritant Rabbit - 400 Micrograms

Eyes - Severe irritant Rabbit - 24 hours 50 Micrograms

Eyes - Severe irritant Rabbit - 1 Percent - Eyes - Severe irritant Rabbit - 0.5 minutes 1 milligrams

Skin - Mild irritant Human - 24 hours 2 Percent

Skin - Severe irritant Rabbit - 24 hours 500 milligrams reaction mass of: 5-chloro- 2-methyl-4-isothiazolin-3-one [EC no. 247-500-7] and 2-methyl-2H-isothiazol-3-one [EC no. 220-239-6] (3:1)

Skin - Severe irritant Human - 0.01 Percent -

Product/ingredient name Result Score Exposure Observation

Sensitization

Not available.

Species

Specific target organ toxicity (single exposure)

Information on toxicological effects

Date of issue/Date of revision : 5/12/2017 Date of previous issue : 1/22/2016 Version : 1.05 6/12

Section 11. Toxicological information

Not available.

Information on the likely routes of exposure

Inhalation : No known significant effects or critical hazards.

No known significant effects or critical hazards.:Ingestion

Skin contact : Causes skin irritation. May cause an allergic skin reaction.

Causes serious eye irritation.:Eye contact

Once sensitized, a severe allergic reaction may occur when subsequently exposed to very low levels.

General :

No known significant effects or critical hazards.Carcinogenicity :

No known significant effects or critical hazards.Mutagenicity :

No known significant effects or critical hazards.Teratogenicity :

Developmental effects : No known significant effects or critical hazards.

Fertility effects : No known significant effects or critical hazards.

Symptoms related to the physical, chemical and toxicological characteristics

Skin contact

Ingestion

Inhalation No specific data.

No specific data.

Adverse symptoms may include the following:

irritation redness

Eye contact : Adverse symptoms may include the following:

pain or irritation watering redness

Potential chronic health effects

Delayed and immediate effects and also chronic effects from short and long term exposure

Specific target organ toxicity (repeated exposure)

(R*,R*)-(±)-1,4-dimercaptobutane-2,3-diol Category 3 Not applicable. Respiratory tract irritation

Name Category

Not available.

Numerical measures of toxicity

Acute toxicity estimates

Aspiration hazard

Not available.

Route of exposure

Target organs

: Not available.

Potential acute health effects

Potential immediate effects

: Not available.

Short term exposure

Potential delayed effects : Not available.

Potential immediate effects

: Not available.

Long term exposure

Potential delayed effects : Not available.

Date of issue/Date of revision : 5/12/2017 Date of previous issue : 1/22/2016 Version : 1.05 7/12

Section 11. Toxicological information

Oral 7653.1 mg/kg

Route ATE value

Section 12. Ecological information

Bioaccumulative potential

Other adverse effects : No known significant effects or critical hazards.

Not available.

Toxicity sodium hydroxide Acute EC50 40.38 mg/l Fresh water Crustaceans - Ceriodaphnia dubia - Neonate

48 hours

Acute LC50 125 ppm Fresh water Fish - Gambusia affinis - Adult 96 hours

Product/ingredient name SpeciesResult Exposure

Persistence and degradability

Soil/water partition coefficient (KOC)

: Not available.

Mobility in soil

Not available.

Section 13. Disposal considerations The generation of waste should be avoided or minimized wherever possible. Disposal of this product, solutions and any by-products should at all times comply with the requirements of environmental protection and waste disposal legislation and any regional local authority requirements. Dispose of surplus and non-recyclable products via a licensed waste disposal contractor. Waste should not be disposed of untreated to the sewer unless fully compliant with the requirements of all authorities with jurisdiction.

Waste packaging should be recycled. Incineration or landfill should only be considered when recycling is not feasible. This material and its container must be disposed of in a safe way. Care should be taken when handling emptied containers that have not been cleaned or rinsed out. Empty containers or liners may retain some product residues.

Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains and sewers.

:Disposal methods

Section 14. Transport information

Sodium Hydroxide Solution

III

DOT Classification

No.

UN number

UN proper shipping name

Transport hazard class(es)

Packing group

Environmental hazards

Date of issue/Date of revision : 5/12/2017 Date of previous issue : 1/22/2016 Version : 1.05 8/12

Section 14. Transport information

TDG Classification

Sodium Hydroxide Solution

III

No.

Product classified as per the following sections of the Transportation of Dangerous Goods Regulations: 2.

40-2.42 (Class 8).

ADR/RID

Sodium Hydroxide Solution

III

No.

UN number

UN proper shipping name

Transport hazard class(es)

Packing group

Additional information

Environmental hazards

Additional information

UN number

UN proper shipping name

Transport hazard class(es)

Packing group

Additional information

Environmental hazards

Sodium Hydroxide Solution

III

IMDG

No.

UN number

UN proper shipping name

Transport hazard class(es)

Packing group

Additional information

Environmental hazards

Date of issue/Date of revision : 5/12/2017 Date of previous issue : 1/22/2016 Version : 1.05 9/12

Section 14. Transport information

Sodium Hydroxide Solution

III

IATA

No.

Special precautions for user

Transport in bulk according to Annex II of MARPOL and the IBC Code

Transport within user’s premises: always transport in closed containers that are upright and secure. Ensure that persons transporting the product know what to do in the event of an accident or spillage.

: Not available.

UN number

UN proper shipping name

Transport hazard class(es)

Packing group

Additional information

Environmental hazards

Section 15. Regulatory information U.S. Federal regulations

Clean Water Act (CWA) 311: sodium hydroxide

Clean Air Act Section 112

(b) Hazardous Air Pollutants (HAPs)

: Not listed

Clean Air Act Section 602 Class I Substances

: Not listed

Clean Air Act Section 602 Class II Substances

: Not listed

DEA List I Chemicals (Precursor Chemicals)

: Not listed

DEA List II Chemicals (Essential Chemicals)

: Not listed

TSCA 8(a) PAIR: Poly(oxy-1,2-ethanediyl), α-[(1,1,3,3-tetramethylbutyl)phenyl]-ω-hydroxy- ; 1,1'-oxydipropan-2-ol; Poly(oxy-1,2-ethanediyl), α-[4-(1,1,3,3-tetramethylbutyl)phenyl]-ω-hydroxy-

TSCA 8(a) CDR Exempt/Partial exemption: Not determined

United States inventory (TSCA 8b): Not determined.

SARA 302/304

SARA 304 RQ : Not applicable.

No products were found.

Composition/information on ingredients

SARA 311/312

Classification : Reactive Immediate (acute) health hazard

Date of issue/Date of revision : 5/12/2017 Date of previous issue : 1/22/2016 Version : 1.05 10/12

Section 15. Regulatory information

The following components are listed: SODIUM HYDROXIDE

WARNING: This product contains less than 1% of a chemical known to the State of California to cause birth defects or other reproductive harm.

Massachusetts :

Neomycin sulfate No. Yes. No. No.

Ingredient name Cancer Reproductive No significant risk level

Maximum acceptable dosage level

California Prop. 65

New York : The following components are listed: Sodium hydroxide

New Jersey : The following components are listed: SODIUM HYDROXIDE; CAUSTIC SODA

Pennsylvania : The following components are listed: SODIUM HYDROXIDE

State regulations

(R*,R*)-(±)-1,4-dimercaptobutane-2, 3-diol

6.25 No. No. No. Yes. No.

sodium hydroxide 1.9 No. No. No. Yes. No.

reaction mass of: 5-chloro-2-methyl- 4-isothiazolin-3-one [EC no. 247-500-7] and 2-methyl-2H-isothiazol-3-one [EC

no. 220-239-6] (3:1)

0.003 No. No. No. Yes. No.

Name % Fire hazard

Sudden release of pressure

Reactive Immediate (acute) health hazard

Delayed (chronic) health hazard

Composition/information on ingredients

International regulations

Chemical Weapons Convention List Schedule I Chemicals

: Not listed

Chemical Weapons Convention List Schedule II Chemicals

: Not listed

Chemical Weapons Convention List Schedule III Chemicals

: Not listed

Section 16. Other information History

Date of issue/Date of revision

Version

Notice to reader

Indicates information that has changed from previously issued version.

Key to abbreviations : ATE = Acute Toxicity Estimate BCF = Bioconcentration Factor GHS = Globally Harmonized System of Classification and Labelling of Chemicals IATA = International Air Transport Association IBC = Intermediate Bulk Container IMDG = International Maritime Dangerous Goods LogPow = logarithm of the octanol/water partition coefficient MARPOL = International Convention for the Prevention of Pollution From Ships, 1973 as modified by the Protocol of 1978. ("Marpol" = marine pollution) UN = United Nations

5/12/2017

1.05

Date of issue/Date of revision : 5/12/2017 Date of previous issue : 1/22/2016 Version : 1.05 11/12

Section 16. Other information Allergen :

Date of issue/Date of revision : 5/12/2017 Date of previous issue : 1/22/2016 Version : 1.05 12/12