The pathobiological role of dysregulated pulmonary vascular metabolism in systemic sclerosis-associated pulmonary arterial hypertension

The Department of the Army Medical Command awarded a $554,876 Project Grant to the Regents of the University of California, San Francisco to investigate the pathobiological role of dysregulated pulmonary vascular metabolism in systemic sclerosis-associated pulmonary arterial hypertension. The grant was awarded on August 1, 2022 under the Military Medical Research and Development program (CFDA 12.420) to support basic, applied, and advanced biomedical research that transforms military and public health care.

Under the grant, the University of California, San Francisco will conduct research on the molecular, cellular, and histopathological features of pulmonary hypertension. The University of Colorado will contribute to study design, data interpretation, and research methodology through $123,456 in sub-award funding. Experts at both institutions will analyze human and plasma samples to identify differentially regulated metabolic pathways and changes in energy metabolism associated with exercising pulmonary arterial hypertension patients. Insights gained from this research could help advance medical solutions for pulmonary hypertension in military and civilian settings.