NR4A family as markers and mediators of b cell tolerance in SLE: from antigen discovery to treatment

The University of California, San Francisco will conduct research on NR4A family proteins as markers and mediators of B cell tolerance in systemic lupus erythematosus (SLE) under a three-year, $738,631 Project Grant from the Department of the Army Medical Command. The grant is part of the Military Medical Research and Development program administered by the Department of Defense and aims to transform military and public health through innovative medical research solutions for battlefield injuries and illnesses.

Specifically, the University will investigate NR4A family proteins' role in antigen discovery and their potential as targets for new SLE treatments. Results could help improve diagnosis and management of SLE, an autoimmune disease where the immune system attacks its own tissues. The research also seeks to advance understanding of B cell tolerance and its breakdown in autoimmunity. Outcomes may support the Military Medical Research and Development program's goal of developing medical solutions applicable to service members and the general public.