Project Grant W81XWH2010787

The federal Project Grant award of $581,105.00 from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders (CFDA 93.173) program, supports research to develop natural-based therapies for sensory disorders, particularly aminoglycoside-induced hearing loss. The primary awardee, Creighton University, will 1) design and test piperlongumine derivatives with improved properties for targeting the TRPV1 channel, 2)...

Auricle, Inc. received a $305,995 Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), effective September 1, 2025, through August 31, 2026. The award supports development of a novel in-home neuromodulatory medical device designed to treat the underlying cause of tinnitus by addressing dysregulated neural synchrony, the root pathological mechanism of the...

The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded the University of Southern California (USC) a $456,500 Project Grant (CFDA 93.173) to develop a novel diagnostic test for sensory hearing loss. The "Gain-Sensitive Cochlear Microphonics" (GCM) test aims to assess the functional state and site of damage within the cochlear amplifier, which is crucial for hearing sensitivity and range. The proposed research will validate the GCM test in mice by comparing...

This federal Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), provides $275,737 to Rewire Neuroscience LLC to develop and validate a machine learning platform for predicting the ototoxic potential of pharmaceutical compounds. The key objectives are to: 1) optimize and apply an innovative machine learning model that can categorize drugs as ototoxic or...

The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded a $673,350 Project Grant under the "Research Related to Deafness and Communication Disorders" (CFDA 93.173) federal grant program to Xyken, LLC, a minority-owned small business located in McLean, Virginia. The funding supports the development of an accessible, low-cost, and customized hearing aid manufacturing system that leverages smartphone-based 3D ear imaging, automated shell generation, and 3D...

Federal Project Grant Award Summary Massachusetts Eye and Ear Infirmary received a $473,749 Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), with an award date of September 11, 2025, and completion date of August 31, 2027. The grant supports an in silico screening and in vivo evaluation initiative to repurpose FDA (Food and Drug Administration)-approved...

Federal Project Grant Award Summary Merrimack College received a $249,000 Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) to develop and utilize a CRISPR-based toolkit for investigating transcription factors involved in hair cell development. The award, which commenced September 2, 2025, and concludes August 31, 2028, supports the creation of mouse...

This $610,725 Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD) supports research into the physiological mechanisms underlying suprathreshold deficits in sensorineural hearing loss. The project, titled "Physiological Determinants of Suprathreshold Deficits in Sensorineural Hearing Loss," will be conducted by researchers at the University of Pittsburgh from May 2, 2025 to April 30, 2030. The key objectives are to: 1) Characterize the...

This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) in the amount of $2,433,859 supports research at The Johns Hopkins University to investigate age-related hearing loss and cognitive decline. The key objectives are to study the molecular, cellular, and connectivity changes in the central auditory system during normal aging and Alzheimer's disease, with the goal of developing targeted therapeutic strategies. The research integrates single-cell sequencing,...

The University of Rochester received a $145,989 Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD) to conduct research on the "Cortical Mechanisms Underlying Aberrant Auditory Perception". The 5-year project, which began on May 1, 2025, will utilize animal models and in vivo imaging techniques to determine whether altered cell-specific activity or disrupted neurotransmitter signaling in the auditory and frontal cortices underlie...