Project Grant W81XWH2010205

This $181,772 project grant from the National Heart, Lung and Blood Institute will support research into coagulopathy in sepsis patients. The grantee, Beth Israel Deaconess Medical Center, will conduct an ancillary study using viscoelastic monitoring to examine the effects of randomly assigned fluid resuscitation strategies on coagulation parameters in sepsis patients. Specifically, the study aims to: 1) analyze how liberal versus restrictive fluid administration impacts coagulation measurements...

This $2,696,634 Cooperative Agreement award, granted by the Uniformed Services University of the Health Sciences under the Uniformed Services University Medical Research Projects program (CFDA 12.750), supports a research project to utilize a novel 3D human brain-like tissue model to investigate the distinct pathological mechanisms triggered by blast and blunt traumatic brain injuries. The primary research objectives are to characterize alterations in mitochondrial dysfunction, axonal structural...

This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), part of the U.S. Department of Health and Human Services, under the Federal Grant Program "Discovery and Applied Research for Technological Innovations to Improve Human Health" (CFDA 93.286), aims to develop and assess novel frameworks for accurately predicting functional recovery following moderate-to-severe traumatic brain injury (TBI). The $389,813 award to the University of...

The Department of the Army Medical Command awarded Tufts University School of Medicine a $813,375 Project Grant through the Military Medical Research and Development program (CFDA 12.420) to investigate metabolic modulation of collagens in the extracellular matrix to preserve GABAergic inhibition after traumatic brain injury. The three-year award beginning August 1, 2022 will support research into medical solutions for traumatic brain injuries sustained on the battlefield. A $813k sub-award...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, will fund research at the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) to investigate the mechanisms linking traumatic brain injury (TBI) to subsequent neurodegeneration and dementia. The $1,975,262 award will support a 3-year study...

This Project Grant award of $613,585.00 from the Defense Health Agency (DHA) supports research by James Cook University's Australian Institute of Tropical Health and Medicine to develop point-of-injury intranasal drug therapies to reduce secondary injury and improve outcomes for individuals with traumatic brain injuries (TBIs) in civilian and military resource-limited environments. This research falls under the DHA's Military Medical Research and Development program (CFDA 12.420), which...

Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $453,860 to Henry Ford Health + Michigan State University Health Sciences on June 1, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. This project grant funds preclinical research investigating the metabolic regulation of neutrophil extracellular traps (NETs) in traumatic brain injury (TBI). The research will examine...

The U.S. Defense Health Agency awarded a $817,200 Project Grant under the Military Medical Research and Development program (CFDA 12.420) to The Roskamp Institute, Inc. in Sarasota, Florida. The grant, awarded on September 1, 2024, will support a 3-year research project titled "Targeting APOE Bioenergetics for Reducing the Risk of Neurodegeneration After Chronic Traumatic Brain Injury." The research aims to investigate mitochondrial bioenergetics, tau protein pathology,...

This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $423,500 to The University of Kentucky Research Foundation to examine the role of transforming growth factor-activated kinase 1 (TAK1) in tau pathology following repetitive mild traumatic brain injury (TBI). The research aims to determine an optimal dosage and treatment regimen for the novel small molecule therapeutic BNC-1 to reduce TAK1 phosphorylation and tau pathology, neurodegeneration, and...

This federal Project Grant award of $2,217,454.00, awarded by the Department of the Army Medical Command under the Military Medical Research and Development program (CFDA 12.420), supports a research study on the effects of transcranial photobiomodulation (PBM) in older adults with traumatic brain injury. The primary awardee is the Research Foundation of the City University of New York, which is collaborating with New York University School of Medicine as a sub-grantee. The research aims to...