Project Grant W81XWH1910487

Renerva LLC, a for-profit manufacturer, is developing peripheral nerve matrix (PNM) technologies to facilitate functional recovery in animal models of direct muscle neurotization (DMN) through a $494,955 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853). The two-year project aims to 1) optimize the formulation of a clinical-grade PNM product to provide...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $999,998 to Renerva LLC, a for-profit biotech company, to develop and optimize their Peripheral Nerve Matrix (PNM) technology. PNM is a tissue-based hydrogel derived from porcine nerve tissue, intended to improve functional outcomes for patients with critical size peripheral...

The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $6,522,833 Project Grant to The Leland Stanford Junior University to conduct a mechanistic randomized clinical trial investigating the central and peripheral nervous system mechanisms of pain relief induced by peripheral nerve stimulation (PNS) for the treatment of refractory chronic neuropathic pain. The 3-year study, funded under the NIH HEAL Initiative's CFDA 93.279 Drug Abuse and Addiction Research Programs, aims...

The federal Project Grant award R41NS135845 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $296,151 to Insoma Bio, Inc. to investigate the use of the company's proprietary Fractomer biomaterial in improving outcomes for peripheral nerve repair. The two-year project, running from August 1, 2024 to July 31, 2025, aims to demonstrate that Fractomer, an...

The National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health, awarded Backstop Neural, Inc. a $970,052 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop a novel softening epidural stimulation lead for treating chronic arm and neck pain. The project aims to design and fabricate a thin, flexible 16-channel epidural lead that can conform to the spinal cord and provide stable, long-term stimulation. Key...

This $500,000 Project Grant awarded by the National Science Foundation (NSF) under the Engineering program (CFDA 47.041) supports research by Cleveland State University to develop bioprinted tissue scaffolds with Schwann cell density gradients and electrical conductivity for peripheral nerve regeneration. The key objectives are to: 1) determine how Schwann cell density gradients impact axonal regrowth, 2) explore how scaffold electrical conductivity affects neural axon growth, and 3) evaluate...

This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $628,012 in funding to the University of Wisconsin System to develop and validate a novel minimally invasive electrode strategy to better isolate the posterior tibial nerve for the treatment of overactive bladder (OAB). The key products to be delivered under this award...

This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), is focused on enhancing pain management for knee replacement patients through an innovative non-invasive and opioid-sparing device. The $416,443 award to NCAP Medical, LLC will fund a randomized placebo-controlled clinical trial to evaluate the use of the "Neurocuple" device as a non-pharmacological postoperative pain relief treatment following...

The University of Nebraska Medical Center (UNMC) was awarded a $437,331 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant will support the development of a novel "optoelectronically active nerve adhesive" to accelerate peripheral nerve repair and regeneration. Specifically, the project aims to incorporate innovative...

This $401,425 Project Grant was awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) to Albany Medical College to conduct research on the axo-glial interface in aging and its impact on peripheral nerve regeneration. The research aims to: Establish the proteomic profile of aged Schwann cell pseudopods when interacting with demyelinated axons, and Compare the proteome between young and aged Schwann cells during axon re-engagement and remyelination. The goal is to develop a...