Project Grant W81XWH1810017

The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded a $305,628 Project Grant under the CFDA 93.173 Research Related to Deafness and Communication Disorders program to Echogenesis Therapeutics Inc. The grant will fund the development of a cell-type-specific gene therapy approach to treat congenital hearing loss caused by mutations in the TOMT gene. Specifically, the project aims to: 1) determine effective dosages for hearing restoration, 2) establish the optimal...

This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), provides $581,105 to Creighton University to develop natural-based therapies for treating hearing loss caused by aminoglycoside antibiotics. The key focus is on designing, synthesizing, and testing piperlongumine derivatives that can better target the TRPV1 channel to protect hair cells and synapses...

The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded a $275,371 Project Grant (CFDA 93.173) to Auricle Health Inc. to develop an extracochlear device to restore hearing for patients with sensorineural hearing loss (SNHL). The funding will support refinement of the electrode design, demonstration of electrical stimulation of the cochlear nerve in animal models, and evaluation of the long-term safety and durability of the implant. This project aims to create a...

The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded Jacaranda Biosciences, Inc. a $304,762 SBIR Phase 1 Project Grant under the Research Related to Deafness and Communication Disorders program (CFDA 93.173). The funding will support the development of novel JBI compounds that function through the unfolded protein response (UPR) to prevent the ototoxicity and hearing loss caused by cisplatin chemotherapy treatment. The key objectives are to optimize the efficacy...

The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded a $498,000 Project Grant under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) to the University of Pittsburgh. The project aims to develop an ex-vivo porcine round window membrane (RWM) model to evaluate the transport of nanovesicles, including extracellular vesicles (exosomes), as a method for non-surgical delivery of therapeutics to the inner ear to treat and prevent hearing...

This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), provides $767,494 to the University of Miami to develop human inner ear organoid platforms for studying genetic hearing loss and vestibular disorders. The key objectives are to: 1) establish and optimize human induced pluripotent stem cell-derived 3D inner ear organoid systems from patients with...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $387,500.00 to The Johns Hopkins University from January 1, 2025 to November 30, 2029 to elucidate the gene regulatory networks that control hair cell regeneration in zebrafish. The research aims to identify key transcription factors, such as SOX and SIX, that regulate the transition of support cells to a progenitor state capable of...

This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), will provide $434,411 to Brandeis University to conduct research on the mechanisms of chemosensory neuron cilia regeneration. The goal is to identify the sensors, transducers, and effectors that drive the regrowth and restoration of function in sensory neuron cilia, which play a critical role in...

This federal Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), provides $149,804.00 to The Jackson Laboratory to study the role of the ACO2 gene in progressive hearing loss. The key goals of this 3-year research project are to: 1) Track spiral ganglion neuron (SGN) defects in ACO2 R56L mutant mice from developmental stages to young adulthood; 2)...

This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the federal Research Related to Deafness and Communication Disorders program (CFDA 93.173), provides $147,486 to Emory University to study the neural mechanisms underlying recovery of sound localization after unilateral hearing loss in mice. The research aims to determine how changes in neural activity in the auditory cortex and inferior colliculus drive behavioral recovery of...