This Project Grant award from the National Science Foundation's Division of Chemistry (CFDA 47.049 - Mathematical and Physical Sciences) is providing $399,997 to the University of Washington to advance hydrogen/deuterium exchange mass spectrometry (HDX-MS) for studying protein structure and dynamics. The key objectives are to: 1) develop internal standards to improve the reproducibility of HDX-MS measurements, 2) create software tools for more robust analysis of HDX-MS data to better detect...
The National Science Foundation awarded a $310,000 Project Grant to Case Western Reserve University to acquire a matrix-assisted laser desorption/ionization time-of-flight mass spectrometer (MALDI-TOF MS) under the Mathematical and Physical Sciences program (CFDA 47.049). This specialized instrument will enable a wide range of innovative research activities across 8 departments, including analysis of fragile macromolecules, complex biomaterials, and synthetic polymers. The new equipment will...
This Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) provides $1,105,757 to the University of Rochester to acquire a state-of-the-art TIMSTOF HT mass spectrometry and liquid chromatography system. This advanced instrumentation will significantly enhance the proteomic analysis capabilities of the University of Rochester Mass Spectrometry Resource Laboratory, enabling high-throughput, high-resolution quantitative...
This federal Project Grant award from the National Institutes of Health (NIH) Office of the Director, under the NIH Research Infrastructure Programs (CFDA 93.351), provides $1,759,412 to the Buck Institute for Research on Aging to acquire a Bruker TIMSTOF FLEX MALDI-2 mass spectrometry system for spatial molecular imaging.
The instrument will enable the Buck Institute and a collaborative network of 18 independent investigators from 8 institutions to spatially resolve molecular signatures,...
This $731,896 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) will support novel ion chemistry and instrument development for the characterization of proteins, nucleic acids, and heterogeneous bio-complexes via tandem mass spectrometry. The research aims to extend the utility of mass spectrometry and tandem mass spectrometry in top-down biopolymer characterization, as well as in the mass...
This federal Project Grant award from the National Institutes of Health (NIH) Research Infrastructure Programs (CFDA 93.351) for $827,060 will fund the acquisition of a new Mediso NanoScan preclinical SPECT-CT imaging system at Case Western Reserve University (CWRU) in Cleveland, Ohio. The new imaging system will restore SPECT-CT imaging capabilities in the region that were lost prior to the COVID-19 pandemic, and will enable enhanced preclinical research across a range of areas including...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $1,166,190 to Michigan State University to advance capillary electrophoresis-mass spectrometry (CE-MS) techniques for top-down proteomics. The project aims to develop novel CE-MS methods to characterize peptides, proteoforms, and protein complexes in human cells and early vertebrate embryos, with the goal of creating the...
This $1,211,143 federal Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) will fund the acquisition of a state-of-the-art 700 MHz NMR spectrometer with a cryogenically cooled probe for the University of Pittsburgh Department of Structural Biology. The new instrument will replace an aging 20-year-old spectrometer and enable reliable, high-sensitivity structural and dynamic analysis of a wide variety of biological systems,...
This $250,000 Project Grant award from the Department of Health and Human Services' National Institutes of Health (CFDA 93.351 - Research Infrastructure Programs) supports the acquisition of an Agilent 1290 Infinity Series II Ultra-High-Performance Liquid Chromatography (UHPLC) system with a 6530 Quadrupole Time-of-Flight (QTOF) mass spectrometer at Montana State University Billings (MSUB). This cutting-edge analytical instrumentation will enable advanced investigations into disease...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $402,500.00 in funding to Case Western Reserve University, Office of Research Administration Division (doing business as University Hospitals of Cleveland), from July 1, 2024 to May 31, 2029.
The award will support the development and application of innovative tools to capture subcellular information for individual RNA...
This federal Project Grant award from the Department of Health and Human Services, National Institutes of Health under the Research Infrastructure Programs (CFDA 93.351) provides $750,000 to Case Western Reserve University to acquire a state-of-the-art, integrated mass spectrometry-based system for hydrogen/deuterium exchange (HDX-MS) studies on complex protein systems. This advanced instrumentation will support a large community of over 30 biomedical researchers across multiple institutions in the greater Cleveland area, enabling critical structural biology research and fostering collaborative interactions. The award period is from April 15, 2025 to April 14, 2026. The HDX-MS technology will be an invaluable tool for characterizing protein complexes, aggregates, and interactions, with applications spanning neurodegenerative disorders, cancer, cardiovascular diseases, and more. This investment aims to expand the scope of biomedical research and develop novel therapeutic strategies for various diseases.