This Project Grant award from the National Science Foundation's (NSF) Division of Chemistry, under the Mathematical and Physical Sciences (CFDA 47.049) Federal Grant Program, provides $551,717 in funding to the University of Washington for a 3-year project period from August 1, 2024 to July 31, 2027. The project, led by Professor Frantisek Turecek, focuses on developing new chemical reactions for crosslinking biomolecular ions representing components of proteins and nucleic acids. The research...
This $390,000 National Science Foundation Project Grant, awarded under the Mathematical and Physical Sciences program (CFDA 47.049), will support the development of Absolute Quantitative Protein Footprinting Mass Spectrometry (AQPFMS) for probing protein three-dimensional structures. Professor Hao Chen of the New Jersey Institute of Technology and collaborator Xiaolin Cheng of Ohio State University will refine an approach using AQPFMS to provide quantitative analysis of solvent-accessible...
The federal Project Grant award of $750,000 from the National Institutes of Health (NIH) Office of Research Infrastructure Programs (CFDA 93.351) will be used by Case Western Reserve University (CWRU) to acquire a state-of-the-art, integrated mass spectrometry-based system for hydrogen/deuterium exchange (HDX-MS) studies on complex protein systems. This specialized equipment will support a large community of biomedical researchers at CWRU and neighboring institutions, including the Cleveland...
This $299,644 Project Grant award from the National Science Foundation (NSF) Division of Chemistry, under the Mathematical and Physical Sciences program (CFDA 47.049), supports the development of software infrastructure to enable real-time analysis of molecular dynamics simulation data. The project aims to create a streaming protocol that transfers simulation data directly to analysis software, avoiding the need for storage of massive data files. This approach allows for simultaneous analysis of...
The National Science Foundation Division of Chemistry awarded a $1,010,000 project grant to the University of Texas at Austin to develop innovative mass spectrometry methods for characterizing intact proteins through June 2025 under the Mathematical and Physical Sciences program (CFDA 47.049). Professor Jenny Brodbelt and her research group will apply ultraviolet photodissociation and other dynamic ion manipulation strategies to amplify structural and post-translational modification details...
This Project Grant award of $1,500,000 from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) supports research to elucidate the design principles for de novo designed proteins as mechano-responsive junctions in protein-polymer networks. The key products and services to be delivered include: (1) Development of de novo designed proteins that can be readily transformed into junctions within polymer networks. (2) Investigation of the use of de novo...
This federal Project Grant award, valued at $476,385.00 and funded by the National Science Foundation's (NSF) Division of Chemistry, supports a collaborative research project between Professor Michael Marty's team at the University of Arizona and industrial partners at Genentech, Inc. The project aims to develop new computational algorithms and experimental methods for improved analysis of complex mass spectrometry data, particularly focused on enabling more widespread use of intact mass...
This $399,935 federal Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) supports research conducted by Professor Kyriakos C. Stylianou and his team at Oregon State University. The research aims to develop a deeper understanding of the fundamental mechanisms underlying metal-organic framework (MOF)-based photocatalysis, with a focus on investigating hydrogen-deuterium isotope exchange reactions. The project will use in-situ...
The National Science Foundation (NSF) Division of Chemistry awarded a $420,000 Project Grant to the Regents of the University of Michigan under the Mathematical and Physical Sciences program (CFDA 47.049) to develop new high-throughput technologies for characterizing the 3-dimensional structures of proteins and RNA. Specifically, the funding will support Professor Brandon Ruotolo and his research team in expanding the capabilities of Collision Induced Unfolding (CIU) - an approach that uses...
The National Science Foundation (NSF) Division of Chemistry awarded a $710,000 Project Grant to Boise State University under the Mathematical and Physical Sciences program (CFDA 47.049) to acquire a high-resolution liquid chromatography-mass spectrometry (LC-MS) system. This system will enhance research infrastructure and enable new capabilities in proteomics and metabolomics research at the university. The grant will support graduate, undergraduate, and high school student training in modern...