Project Grant RM1GM158451
- This $254,182 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will fund the development of a novel, unified X-ray/cryo-EM pipeline for ensemble-based structural refinement. The project aims to address the significant challenges posed by structural disorder, flexibility, and conformational heterogeneity in modern therapeutic modalities, which limit the accuracy of traditional refinement...
- This $1,444,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop new cryogenic electron microscopy (cryo-EM) methods to visualize the structural heterogeneity of ribosomes at the single-molecule level in cells. The award, effective September 2, 2024 through August 31, 2027, will enable the principal investigator to pursue strategies to extend a novel technique called 2D template...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $349,999 to Denovx, LLC to adapt the company's surface science approach to improving protein crystallization for enhancing cryogenic electron microscopy (cryo-EM) specimen quality. The goal is to identify physical and chemical modifications to cryo-EM support materials that can enhance the adsorption and random orientation of...
- This Project Grant award of $540,000 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to expand the MicroTutor online platform for microscopy and bioimage analysis education. The primary awardee, President and Fellows of Harvard College, doing business as Harvard Medical School, will add new modules on microscopy best practices and bioimage analysis using open-source tools like Piximi. This will...
- The National Institute of General Medical Sciences (NIGMS) awarded a $2,113,889 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Colorado, Boulder. This 4-year grant, running from September 1, 2025 to August 31, 2029, focuses on enhancing cryogenic sample time-resolved electron microscopy (CryoTREM) capabilities through the development of a patterned LED/LCD-based illumination system. The goal is to capture multiple temporal states of...
- The federal Project Grant award of $420,984.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to develop statistical methods for analyzing deep mutational scanning (DMS) data. The research aims to improve the interpretation of DMS experiments, which can measure how genetic variants affect protein function, in order to better understand the mechanisms underlying basic biology and...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop state-of-the-art software tools capable of accurately modeling bound drug molecules in receptor structures from cryo-electron microscopy (cryo-EM) data with resolutions up to 5-6 Angstroms. The $217,941 award to Molecular Intelligence LLC, a small business, will run from September 1, 2025 to February 28, 2027. This...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $166,017 project grant to the University of California, Los Angeles (UCLA) to purchase an Isothermal Titration Calorimeter (ITC) instrument. The ITC will be used by a group of NIH-supported investigators at UCLA to probe the thermodynamics of protein and nucleic acid complexes involved in various biological processes and diseases, including microRNA...
- This Project Grant award of $501,000.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research by The Regents of the University of California, San Francisco (UCSF) to develop simulation-based models that can more accurately interpret experimental data in structural biology. The goal is to enhance understanding of how macromolecules communicate and interact, which is vital for advancing...
- This federal Project Grant award of $427,625 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop capillaric microfluidics for integrated sample preparation in miniaturized mass spectrometry (mini-MS) systems. The research will focus on creating portable, self-powered, and self-regulated sample preparation capabilities to improve the versatility and applicability of mini-MS instruments for...
This federal Project Grant award for $1,341,283, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports the Microcrystal Electron Diffraction (MicroED) Imaging Center (MEDIC) at the University of California, Los Angeles (UCLA). The MEDIC center is focused on advancing and disseminating the MicroED method, which enables the determination of atomic-resolution structures from extremely small crystals. Since its establishment in 2020, the MEDIC center has trained over 1,000 individuals, developed robust sample preparation and data analysis pipelines, and released software that has been downloaded over 15,000 times. The center has also collaborated with technology partners to develop commercial MicroED systems. This award will support MEDIC's transition to a Biomedical Technology Optimization and Dissemination (BTOD) center, with projects focused on enhancing macromolecular MicroED, optimizing the technique, and driving biomedical applications through selected driving biomedical projects.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.3m | 9/22/25 |