Project Grant RM1DE035338
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $390,000 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Medical College of Wisconsin, Inc. The grant funds a 5-year research project to leverage single-cell co-culture and gene expression profiling to identify tumor antigen-specific T cells in oral squamous cell carcinoma (OSCC). The project aims to develop innovative methods to isolate and characterize tumor-infiltrating...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $1,952,000 Project Grant under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121) to Matregenix Inc., a small disadvantaged business located in California. The grant supports the development of MATRINOVA, an animal-free, amino acid-based biodegradable barrier membrane for guided bone regeneration in dental and craniomaxillofacial surgeries. The research aims to create a membrane with a unique...
- This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $688,679 to the University of Southern California (USC) to develop innovative technology for comprehensively mapping the transcriptomes and lineage histories of all cell types in the vertebrate face. The project aims to define the diversity of mesenchymal progenitors, lineage relationships, and variations across...
- This federal Project Grant award of $600,029.00, funded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to investigate the mechanisms by which dysregulation of the Ras/MAPK signaling pathway leads to craniofacial and dental abnormalities in Rasopathy syndromes. The awardee, Cedars-Sinai Medical Center, will use a combination of comparative morphometrics, transcriptomic, proteomic, and...
- This federal Project Grant award, valued at $294,000 and spanning September 2024 to September 2026, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program. The grant supports research to understand the mechanisms of craniofacial cartilage differentiation from human neural crest stem cells, with the goal of developing tissue engineering approaches to repair birth defects and injuries to the head and...
- This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $557,606.00 to fund a research project titled "Cellular and Molecular Control of Periodontal Tissue Regeneration" at Harvard Medical School. The award aims to advance fundamental knowledge about periodontal stem cells and mechanisms for natural periodontal tissue regeneration, with a focus on the periodontal...
- The Project Grant award of $205,000.00, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program, will support research to investigate the relationship between the oral microbiome and adverse outcomes in pediatric hematopoietic cell transplant recipients. The key products and services to be delivered under this award include: Collecting oral samples (supragingival plaque and saliva) and blood samples...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $685,594 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to The Pennsylvania State University (Penn State) to support research on leveraging microsurgery and bioprinting to enable rapidly vascularized tissue engineering for craniomaxillofacial (CMF) injury reconstruction. The project aims to advance a novel microsurgical "vascular micropuncture" technique to enhance the...
- This federal Project Grant award of $588,952 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), is funding research to develop a bio-inspired scaffold (PerióPatch) for regenerating Sharpey's fibers and the periodontal ligament (PDL). The research aims to integrate biophysical and biochemical cues into a matrix to guide PDL stem cell migration, growth, and the formation of well-aligned PDL principal and...
- The National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), awarded a $298,942 Project Grant to Deltamed LLC on August 20, 2025. The grant funding will support the development of a novel "nanosponge prodrug delivery system" for the small molecule MK2 inhibitors apatinib and MMI-0100. The goal is to improve the circulation half-life and targeted delivery of these compounds to mitigate...
This Project Grant award, funded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports the co-development of autologous oral mucosal grafts for therapeutic purposes. The $1,240,877 award to Cedars-Sinai Medical Center aims to engineer vascularized, functional oral tissue grafts that can be tailored to diverse clinical needs, leveraging advances in single cell/spatial multiomics, developmental biology, stem cell biology, and bioengineering. The 5-year project, running from August 2025 to May 2030, seeks to build on the researchers' prior work to identify key progenitor populations and develop protocols for producing iPSC-derived oral epithelial and mesenchymal populations for tissue engineering. The goal is to generate scalable, vascularized, autologous grafts that mimic keratinized and non-keratinized oral mucosa, reducing rejection and improving outcomes for clinical applications.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.2m | 8/15/25 |