The National Institute of Dental and Craniofacial Research (NIDCR) awarded a Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to the Research Institute at Nationwide Children's Hospital (RINCH). The $170,746 award, with a performance period from August 2024 to July 2026, will fund research to investigate the oral microbiome and its relationship to oral mucositis and bloodstream infections in children undergoing hematopoietic cell transplants. The research will...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, provides $460,885 over a 5-year period from March 2025 to February 2030 to The Trustees of the University of Pennsylvania, doing business as the Clinical Practices of the University of Pennsylvania. The award supports research to investigate how the interaction between the fungus Candida albicans and the bacterium Streptococcus...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will fund a longitudinal study of the oral microbiome in HIV-exposed uninfected (HEU), HIV-positive, and HIV-unexposed uninfected children aged 3-4 years in western Kenya. The $157,500 award, with a project period from Sep 20, 2024 to Aug 31, 2026, will support the collection and analysis of 1,080 oral swab samples to...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $236,250 to investigate the relationship between adverse childhood experiences (ACEs), oral microbiome dysbiosis, and dental caries in children. The research aims to identify potential causative mechanisms between ACEs, the brain-oral microbiome axis, and increased risk of dental caries in children, with the...
This $148,614 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to investigate the microbial basis of early childhood caries (ECC) through integrative analysis of metagenomics, metatranscriptomics, and metabolomics data. The award will support the development of new statistical methods and machine learning strategies to characterize ECC-related microbial dysbiosis, biochemical...
This $745,966 Project Grant awarded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) is funding research to investigate a novel biosynthetic gene cluster (BL-BGC) in the bacterium Streptococcus mutans and its impact on virulence and survival traits related to dental caries. The 3-year award to Oregon Health & Science University aims to characterize the phenotypes of clinical S. mutans strains containing...
This federal Project Grant award for $234,000.00, issued by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to investigate the functional roles and mechanisms of the human microbiome in oral squamous cell carcinoma (OSCC) pathogenesis. The study aims to define OSCC-associated metagenomic and metabolomic signatures, and determine whether microbiota transfer from human OSCC cases to mouse...
This Project Grant award of $1,839,472 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to define dysbiosis and identify microbial changes that are predictive of periodontitis progression and stability. The project aims to utilize the biobank and longitudinal data from the previous "Biomarkers of Periodontal Disease Progression (BPDP)" study to examine microbial,...
This $162,216 Federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to investigate microbe-microbe interactions within the oral microbiome at the single-cell level. The key products and services to be delivered through this award include: Developing an approach that combines multiplex FISH imaging with expansion microscopy to study the spatial organization and functional...
This Project Grant award of $409,403.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121), supports the development of a comprehensive qPCR-based oral microbiome profiling platform by Branchpoint Biosciences Inc. The key objectives are to (1) determine the optimal oral microbiome targets by analyzing public metagenomic data, and (2) design and validate qPCR assays to accurately screen the...