Project Grant RF1NS148618
- The National Institute of Neurological Disorders and Stroke awarded Rutgers The State University of New Jersey, doing business as RBHS-School of Nursing, $1.84 million on September 5, 2026, to investigate phosphodiesterase 2A signaling in traumatic brain injury and Alzheimer's disease under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The project examines how phosphodiesterase 2A modulates voltage-dependent anion channel 1...
- The National Institute on Aging awarded Rutgers The State University of New Jersey $1,401,551 on December 15, 2025, under the Aging Research program (CFDA 93.866) to investigate the role of amyloid precursor protein (APP) metabolites in extracellular vesicle cargo and function in Alzheimer's disease. The recipient will conduct three research aims. The first aim investigates the molecular mechanism of APP-related cargo loading into extracellular vesicles (EVs). The second aim tests the effect...
- The National Institute of Neurological Disorders and Stroke awarded Rutgers The State University of New Jersey $617,246 on September 26, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the toxicity of lipid-rich alpha-synuclein inclusions in Parkinson's disease pathology. The research examines Lewy bodies and related lipid-rich alpha-synuclein inclusions prevalent in the substantia nigra and brainstem regions....
- The National Institute of Neurological Disorders and Stroke awarded Rutgers The State University of New Jersey $607,954 on July 16, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research to identify and validate the chokepoints of epileptogenic networks in mesial temporal lobe epilepsy—specific brain regions where multiple ictogenic pathways converge—to improve surgical outcomes for patients with drug-resistant...
- The National Institute on Aging awarded Rutgers The State University of New Jersey $1,313,154 on July 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the role of ITM2B/BRI2 in the pathogenesis of familial British dementia and familial Danish dementia, conditions sharing similarities with Alzheimer's disease. The research examines BRI2's impact on synaptic plasticity, learning and memory, neuroinflammation, and cell type-specific changes in microglia and neurons using...
- The National Institute of Neurological Disorders and Stroke awarded Rutgers, The State University $118,593 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Assistance Listing). The award funds research investigating the role of dorsal horn interneurons expressing the serotonin 6 receptor (5HTR6+ interneurons) in sensorimotor integration within the spinal cord under both normal conditions and following spinal cord...
- The National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health, awarded Rutgers The State University of New Jersey, School of Nursing, $474,749 on August 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the molecular and cellular mechanisms governing functional maturation and adult subtype diversification in spinal motor neurons. The project addresses postnatal...
- The National Heart, Lung, and Blood Institute awarded Rutgers The State University of New Jersey, School of Nursing, $117,750 on May 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct proteomic profiling and neurocognitive assessment to uncover stroke mechanisms in adults with sickle cell disease. The study quantifies neurodegeneration-associated and mitochondrial proteins in a cohort of 90 sex- and age-matched adults comprising 30 healthy controls, 30...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded Rutgers, The State University $573,035 on February 15, 2026, under the Aging Research program (CFDA 93.866) to investigate the control of cerebrospinal fluid hydrodynamics and brain-waste clearance mechanisms. The research examines how the glymphatic system facilitates the clearance of neurotoxic proteins such as amyloid-beta and tau, which accumulate in aging and neurodegenerative diseases including...
- The National Institute on Aging awarded Rutgers, The State University $225,256 on May 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the role of big tau protein in preventing tau pathology in Alzheimer's disease. The research examines why selective brain regions such as the cortex and hippocampus develop tau pathology in Alzheimer's disease while the cerebellum and brainstem largely remain intact. The investigator has identified big tau, a tau isoform with a...
The National Institute of Neurological Disorders and Stroke awarded Rutgers The State University of New Jersey $1.872 million on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate fibrinogen-mediated mechanisms in cerebral amyloid angiopathy. The research elucidates molecular mechanisms underlying cerebral amyloid angiopathy, a cerebrovascular pathology affecting over 80 percent of Alzheimer's disease patients. Work focuses on how fibrinogen—a blood clotting protein—exacerbates pathology through interaction with amyloid-beta and co-deposition in perivascular spaces, disrupting aquaporin-4 polarization on astrocyte endfeet and impairing perivascular clearance. The project investigates how fibrinogen-amyloid-beta co-deposition impairs clearance and alters aquaporin-4 polarization in cerebral amyloid angiopathy mouse models and human tissue, defines the role of caveolin-1–mediated transcytosis in fibrinogen extravasation, and examines downstream neuroinflammatory consequences and therapeutic targets. The research spans basic mechanisms in animal models and translational validation in human cerebral amyloid angiopathy tissue. The recipient is Rutgers The State University of New Jersey, doing business as RBHS-School of Nursing, a child entity of Rutgers headquartered in New Brunswick, New Jersey and performing work at its Newark, New Jersey location. Performance runs through August 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.9m | 8/31/26 |