Project Grant R21MH144609
- The National Institute of Mental Health awarded Icahn School of Medicine at Mount Sinai $763,265 on August 18, 2026, under the Mental Health Research Grants program (CFDA 93.242) to characterize splicing and isoform dysregulation in autism spectrum disorder at cellular resolution. The recipient will profile postmortem prefrontal cortex brain tissue from 74 individuals with ASD and 74 neurotypical controls across the lifespan, from childhood to adulthood, using long-read multiplexed arrays...
- The National Institute of Mental Health awarded Icahn School of Medicine at Mount Sinai $169,701 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct multiomic and spatial profiling of hippocampal development and subfield specification. The research deploys single-nucleus RNA sequencing, single-nucleus ATAC sequencing, and spatial sequencing on human fetal hippocampal and neocortical tissue (gestational weeks 16–24) and human induced pluripotent stem...
- The National Institute of Mental Health awarded Icahn School of Medicine at Mount Sinai $839,815 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct a clinical and translational research project investigating neuroimmune mechanisms of depression and anhedonia. The project tests the hypothesis that heightened peripheral immune function and increased blood-brain barrier permeability contribute to major depressive disorder and anhedonia severity. Work is...
- The National Institute of Mental Health awarded The Trustees of Columbia University in the City of New York $534,191 on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop robust fine-mapping tools for genetic discovery in neuropsychiatric traits using deep phenotype data from diverse populations. The project addresses the challenge of understanding genetic causes of complex neuropsychiatric conditions including autism spectrum disorders, bipolar disorder, and...
- The National Institute of Mental Health awarded Icahn School of Medicine at Mount Sinai $827,879 on March 25, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate ghrelin receptor and striosomal interactions in stress-induced decision-making. The award supports basic neuroscience research examining how chronic stress exposure alters decision-making through interactions between neural circuits and endocrine mechanisms. The research uses mouse models to explore how...
- The National Institute of Neurological Disorders and Stroke awarded Icahn School of Medicine at Mount Sinai $1,967,309 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to dissect the role of small non-coding RNAs in microglia-driven neuroinflammation in Alzheimer's disease. The funded research will elucidate how small non-coding RNAs—including microRNA isoforms, transfer RNA-derived fragments, ribosomal RNA-derived...
- The National Institute of Mental Health awarded Icahn School of Medicine at Mount Sinai $701,763 on April 24, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the role of the ventral CA1 hippocampal subregion in valence-associated social memories and emotional memory processing. The five-year project, which runs through January 31, 2031, will uncover the neural circuits mediating positive and negative social memories, identify hippocampal cell types supporting...
- The National Institute of Mental Health awarded Yale University $157,388 on July 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to functionally characterize somatic mosaic variants in the brains of patients with schizophrenia and autism and determine their causal roles in neurodevelopmental disease. The funded work applies massively parallel reporter assays, CRISPR technology, and human induced pluripotent stem cell-derived neural progenitor cells and post-mitotic neurons...
- The National Institute of General Medical Sciences awarded Icahn School of Medicine at Mount Sinai $462,000 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to advance spatial imaging frameworks that reveal how non-coding RNAs organize within the nucleus across developmental and environmental contexts. The research establishes three interconnected themes. Theme 1 extends RNA MERFISH to profile small non-coding RNAs by incorporating enzymatic...
- The National Institute of Mental Health awarded $1.579 million to the Research Foundation For Mental Hygiene, Inc., operating as the New York State Psychiatric Institute, on July 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to fund basic neuroscience research into the circuit mechanisms by which early-life adversity produces sustained reward deficits. The research examines how childhood trauma—including abuse, neglect, and chronic stress—alters neural circuits governing...
The National Institute of Mental Health awarded Icahn School of Medicine at Mount Sinai $462,000 on August 14, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop a novel spatial transcriptomics platform and investigate RNA-binding protein function in human neurons as it relates to schizophrenia risk. The award funds two primary aims. The first develops a spatial RNA-protein interactome MERFISH (SPRIM) platform to visualize endogenous RNA-protein interactions at subcellular resolution through antibody-guided localization, in situ tagmentation, and multiplexed RNA detection. The second aim investigates the roles of serine/arginine repetitive matrix protein 2 (SRRM2) in engineered human induced neurons using adeno-associated virus-based gene editing, spatial imaging, and electrophysiology to assess how SRRM2 heterozygous loss affects RNA splicing, transcript localization, and neuronal electrophysiological properties. This is a Project Grant assistance type with a period of performance through August 13, 2028. Work is performed in New York, New York. The funding mechanism supports exploratory research intended to uncover foundational principles of RNA-binding protein-mediated RNA regulation in brain development and psychiatric disease.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $462.0k | 8/18/26 |