Project Grant RF1NS145336
- The National Institute of Neurological Disorders and Stroke awarded Rutgers The State University of New Jersey $1.872 million on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate fibrinogen-mediated mechanisms in cerebral amyloid angiopathy. The research elucidates molecular mechanisms underlying cerebral amyloid angiopathy, a cerebrovascular pathology affecting over 80 percent of Alzheimer's disease...
- The National Institutes of Health Office of the Director awarded $471,000 to Rutgers The State University of New Jersey, doing business as RBHS-School of Nursing, on August 15, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to support Project Grant R01NS144283 investigating astrocyte-based mechanisms of organophosphate poisoning. The award funds research examining how astrocytes—glial cells abundant in the brain—contribute to injury from acute organophosphate exposure,...
- The National Institute of Neurological Disorders and Stroke awarded The Trustees of the University of Pennsylvania $658,729 on September 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct a pooled cohort study examining associations between traumatic brain injury across the life course and later-life cognitive decline and dementia risk. The research leverages existing data from four NIH-funded ongoing prospective...
- The National Institute of Neurological Disorders and Stroke awarded New Jersey Institute of Technology $559,641 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). NJIT is developing ultrasound-activated therapeutic gas microbubbles for treatment of mild traumatic brain injury induced by repetitive low-level blasts. The research targets military, law enforcement, veterans, and civilian personnel exposed repeatedly to...
- The National Institute of Neurological Disorders and Stroke awarded Brown University $254,400 on May 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop and evaluate a novel therapeutic targeting brain-derived neurotrophic factor (BDNF) signaling to treat traumatic brain injury. The project will evaluate the efficacy of D-SYN3, a macrocyclic compound targeting the PSD-95 protein to enhance BDNF-TrkB signaling and...
- The National Institute of Neurological Disorders and Stroke awarded Rutgers, The State University $118,593 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Assistance Listing). The award funds research investigating the role of dorsal horn interneurons expressing the serotonin 6 receptor (5HTR6+ interneurons) in sensorimotor integration within the spinal cord under both normal conditions and following spinal cord...
- The National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health, awarded Rutgers The State University of New Jersey, School of Nursing, $474,749 on August 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the molecular and cellular mechanisms governing functional maturation and adult subtype diversification in spinal motor neurons. The project addresses postnatal...
- The National Institute of Neurological Disorders and Stroke awarded Rutgers The State University of New Jersey $607,954 on July 16, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research to identify and validate the chokepoints of epileptogenic networks in mesial temporal lobe epilepsy—specific brain regions where multiple ictogenic pathways converge—to improve surgical outcomes for patients with drug-resistant...
- Federal Project Grant Award Summary Rutgers The State University of New Jersey received a $429,514 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), awarded September 1, 2025, with completion anticipated by August 31, 2027. The research will be conducted at the institution's location in New Jersey and focuses on investigating myelin acquisition and...
- The National Institute of Neurological Disorders and Stroke, a component of the Department of Health and Human Services National Institutes of Health, awarded $232,605 to the University of Pennsylvania on July 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), a Project Grant assistance type. The recipient will isolate and characterize microglial-derived extracellular vesicles as biomarkers for traumatic brain injury. The...
The National Institute of Neurological Disorders and Stroke awarded Rutgers The State University of New Jersey, doing business as RBHS-School of Nursing, $1.84 million on September 5, 2026, to investigate phosphodiesterase 2A signaling in traumatic brain injury and Alzheimer's disease under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The project examines how phosphodiesterase 2A modulates voltage-dependent anion channel 1 phosphorylation and gating behavior to prevent mitochondrial bioenergetic failure in neurons susceptible to traumatic brain injury and its progression to Alzheimer's disease and related dementia. The research focuses on the role of the mitochondrial isoform PDE2A2 in regulating local cyclic nucleotide signaling and preventing mitochondrial DNA leakage following traumatic injury. Prior studies show that PDE2A expression increases in brains of Alzheimer's disease patients and mice exposed to traumatic brain injury, concurrent with decreased cyclic nucleotide levels in both cytosol and mitochondria, and that PDE2A inhibitors rescue traumatic brain injury-induced mitochondrial respiratory deficits. The project will elucidate how VDAC1 phosphorylation and oligomerization contribute to neuroinflammation and neurodegeneration following traumatic brain injury. Performance runs through August 31, 2029, in New Jersey. The award is a project grant providing $1.84 million in obligated funding.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.8m | 9/3/26 |