Project Grant K08NS149384
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $654,218 Project Grant to the University of Maryland, Baltimore on August 1, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The five-year research initiative, scheduled for completion on July 31, 2030, investigates the mechanisms and intervention strategies of cyclic GMP-AMP synthase (cGAS) signaling in brain trauma-induced...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded Massachusetts General Hospital a Project Grant of $322,382 effective June 1, 2026, through March 31, 2031, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). This award supports basic neuroscience research investigating the role of interleukin-1 receptor 1 (IL-1R1) signaling in traumatic brain injury (TBI) outcomes. The research...
- Federal Grant Award Summary East Carolina University received a $770,356 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, effective August 8, 2025, with a completion date of May 31, 2030. The award funds fundamental neuroscience research investigating the regulation of efferocytosis—the process by which phagocytes remove apoptotic cell debris—in...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded a Career Development Award of $233,847 to the University of Pennsylvania, with performance occurring in Philadelphia, PA. The award, issued June 1, 2026, with completion targeted for March 31, 2031, supports Dr. Samuel Shin's development as an independent scientist specializing in iron-associated mitochondrial injury in traumatic brain injury (TBI). The grant funds acquisition of...
- Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Ohio State University a Project Grant of $202,599 on September 1, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). This research project investigates the role of Nuclear Factor-Kappa B (NFκB) in chronic inflammation, microglia priming, and neuropsychiatric complications following diffuse traumatic brain injury (TBI). The primary...
- This federal Project Grant award, valued at $3,102,638.00 and spanning August 15, 2024 to July 31, 2027, was provided by the National Institute on Aging (CFDA 93.866 - Aging Research) to The Trustees of the University of Pennsylvania. The grant aims to develop novel gyrencephalic animal models that can recapitulate the complex neuropathological and clinical features associated with traumatic brain injury (TBI)-induced Alzheimer's disease and related dementias (ADRD). The project will evaluate...
- Federal Project Grant Award Summary Brown University received a $254,400 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), awarded May 1, 2026, with completion targeted for April 30, 2028. The research focuses on developing and evaluating D-SYN3, a novel macrocyclic therapeutic compound that enhances brain-derived neurotrophic factor (BDNF)...
- Federal Project Grant Award Summary The University of Pennsylvania received a $664,458 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective September 1, 2025, through August 31, 2030. This award supports the development and validation of a novel optical imaging technology for prehospital detection of large vessel occlusion (LVO) in acute stroke...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The University of Pennsylvania a Project Grant totaling $2,817,215 on August 7, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The four-year award, scheduled for completion by July 31, 2029, funds research to elucidate the role of TRIM10 protein in maintaining TDP-43 (TAR DNA-binding protein 43) solubility and...
- The U.S. Department of Defense's Military Medical Research and Development program (CFDA 12.420) awarded a $683,442 Project Grant on September 1, 2023 to The Trustees of the University of Pennsylvania to conduct a 3-year study on "Trajectories of Neuroimaging and Blood-Based Biomarkers After Remote Traumatic Brain Injury and Associations with Dementia Risk." The University of Pennsylvania will collaborate with Mayo Clinic on a sub-award to investigate longitudinal changes in brain...
Grant Award Summary The University of Pennsylvania received a $232,605 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective July 1, 2026 through June 30, 2031. This award supports research investigating microglial-derived extracellular vesicles (MDEVs) as biomarkers for traumatic brain injury (TBI). The research utilizes a novel microfluidic chip platform with immunomagnetic sorting technology to isolate cell-specific extracellular vesicles from blood samples, enabling non-invasive monitoring of microglial activity and neuroinflammation following TBI. The primary deliverables include characterization of MDEV molecular signatures across mouse models of contusive TBI at varying injury severities and post-injury timepoints, correlation of microRNA profiles with immunohistochemical markers and functional outcomes, and translation of these findings to human TBI plasma samples. The research is designed to identify injury-specific microglial signatures predictive of functional recovery or chronic impairment, with the ultimate goal of advancing biomarker-driven clinical management strategies and informing novel therapeutic approaches for TBI. This project addresses a critical gap in accessible biomarkers for understanding neuroinflammatory processes and guiding treatment decisions in a condition associated with significant morbidity and mortality.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $232.6k | 6/3/26 |