Project Grant RF1NS145280
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $2,709,695 in funding to The Trustees of the University of Pennsylvania to conduct research on the role of TRIM11 in regulating the proteins TDP-43 and FUS. The research aims to determine how TRIM11 maintains the functional, soluble state of these proteins and if its...
- This $3,081,936 federal Project Grant award was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research at the University of California, San Diego (UCSD) to investigate the mechanisms underlying TDP-43 proteinopathies, which are associated with amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), Alzheimer's disease,...
- This Project Grant award of $460,625 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is supporting research to investigate the roles of the deubiquitylation pathway in TDP-43 pathology associated with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The research is being conducted by the University of Massachusetts Medical School (UMMS) and...
- This $3,360,074 federal Project Grant was awarded on September 15, 2025 by the National Institute on Aging (NIA) under the Aging Research grant program (CFDA 93.866). The grant is funding research led by the University of Pennsylvania to develop short RNA therapeutics that can combat TDP-43 proteinopathy, a key pathological feature of several devastating neurodegenerative disorders including Alzheimer's disease, amyotrophic lateral sclerosis, and frontotemporal dementia. The research aims to...
- This Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the dysfunction of neuroimmune-related processes in animal models of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) associated with TAR DNA-binding protein 43 (TDP-43). The $251,250 award, effective from Apr 1, 2025 to Mar 31,...
- This $461,900 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to study the mechanisms underlying TDP-43 dependent structural deficits in amyotrophic lateral sclerosis (ALS) muscles. The project, conducted by the Pennsylvania State University, aims to investigate how TDP-43, a protein involved in ALS and other neurodegenerative disorders, affects muscle function and structure. The research will utilize non-canonical amino acid...
- This federal Project Grant award, valued at $737,720.00 and provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research at Case Western Reserve University to investigate the role of the ATAD3A protein in regulating the cytoplasmic accumulation of the TDP43 protein, which is a hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia...
- The National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), awarded a $404,058 project grant to the Regents of the University of Minnesota to support a novel approach to restore functional TDP43 for the treatment of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). The goal of the project is to identify small molecule compounds that can stabilize functional, multimerized forms of the TDP43 protein in order to restore its normal RNA...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $460,625 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Massachusetts Medical School (UMASS Medical) to investigate the role of TDP-43 citrullination in amyotrophic lateral sclerosis (ALS) pathogenesis. The project, led by principal investigators Massi and Xu, aims to elucidate how citrullination, a post-translational...
- This federal Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, consolidates multiple research projects into a single larger R35 grant to enable comprehensive exploration of biological mechanisms underlying neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Parkinson's disease. The...
This $2,817,215 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is supporting research to elucidate the role of the TRIM10 protein in maintaining the solubility and function of the TDP-43 protein. TDP-43 misfolds and aggregates in progressive neurodegenerative diseases like amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), and this research aims to understand how TRIM10 can suppress TDP-43 aggregation. The award, with a start date of Aug 7, 2025 and an ultimate completion date of Jul 31, 2029, is being conducted by the University of Pennsylvania, a prominent private research institution. The research seeks to address a critical gap in understanding the cellular factors that can prevent TDP-43 aggregation, which is expected to inform the development of effective therapies for TDP-43 proteinopathies.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.8m | 8/6/25 |