This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $460,625 to the University of Massachusetts Medical School to investigate the role of the deubiquitylation pathway in regulating TDP-43 pathology associated with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The 2-year project will use mouse...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will fund research to develop a novel cellular model for investigating amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The researchers will directly convert patient-derived fibroblasts into neurons, preserving the epigenetic age of the starting cells, in order to...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to develop synthetic replicas of TDP-43 protein filaments associated with frontotemporal dementia and other neurodegenerative diseases. The $442,750 award to Case Western Reserve University will fund research to generate in vitro amyloid fibrils with structures identical to brain-derived TDP-43 filaments. This synthetic model would enable mechanistic studies on disease-relevant TDP-43 aggregation...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $251,250 to the University of Massachusetts Medical School to investigate the role of TDP-43 dysfunction and its impact on innate immune pathways and microglial function in models of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The project aims...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,001,864 to Harvard University to investigate the subcellular mechanisms underlying the selective vulnerability of specific neuron subtypes in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The researchers will quantitatively study the localization of RNA, proteins, and translational regulation in the synapses and soma of vulnerable corticospinal neurons (CSN) and...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $404,058 to the Regents of the University of Minnesota to develop a novel approach to restore functional TDP43 for the treatment of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). The goal is to identify small molecule compounds that can stabilize functional, multimeric forms of the TDP43 protein to prevent its loss of function and toxic aggregation, which are...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $2,307,075 to The Leland Stanford Junior University (Stanford University) to support research aimed at defining novel mechanisms of neurodegenerative diseases and developing new therapeutic strategies. The key activities include: Using a combination of yeast and human genetics to...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is funding research to develop and optimize a new animal model for Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). The $374,349 award to the University of North Carolina at Chapel Hill will support the creation of a CRISPR-integrated mutant mouse line that mimics...
This Project Grant award, valued at $1,106,142 and effective September 1, 2024 through July 31, 2029, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The primary objective is to identify mechanisms of neurofilament regulation and turnover in amyotrophic lateral sclerosis (ALS), a devastating neurodegenerative disorder. Key activities...
The National Institute on Aging awarded Case Western Reserve University $1,785,220 under the Aging Research program (CFDA 93.866) from May 2022 to April 2025. The university will research the role of deubiquitinase USP19 in the pathogenesis of TDP-43, a protein implicated in neurodegenerative diseases like frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Using mouse models, human post-mortem tissues, and molecular and cell biology techniques, the university aims to validate...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the role of the ATAD3A protein in the neuropathology associated with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The $737,720 award to Case Western Reserve University aims to determine the causes and consequences of ATAD3A loss in TDP43-associated ALS/FTD models, assess whether ATAD3A replacement can reduce motor neuron toxicity, and uncover the mechanism by which ATAD3A loss contributes to TDP43 proteinopathy. The project period runs from July 1, 2025 to March 31, 2030 and focuses on understanding the relationship between ATAD3A and TDP43 as a means to potentially mitigate TDP43 toxicity in ALS and FTD.