Project Grant RF1NS144353
- Federal Project Grant Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $3.11 million Project Grant to the University of California, Los Angeles (UCLA) Office of Research Administration, effective August 1, 2025 through July 31, 2029, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). This grant supports the development and validation of human induced pluripotent stem cell (iPSC)-derived hippocampal...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $119,367 to the University of California, San Francisco on August 11, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to support investigative research into the RNA-related functions of tau protein in frontotemporal dementia (FTD). The two-year project, concluding July 31, 2027, focuses on characterizing how tau functions in...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a Project Grant of $146,750 to the University of California, Los Angeles (UCLA), effective July 1, 2026, through April 30, 2031, under the Aging Research program (CFDA 93.866). This award supports research aimed at identifying molecular-neuropathological signatures across Alzheimer's disease (AD), frontotemporal lobar degeneration (FTLD), and Long COVID through advanced single-cell spatial multi-omics analysis on...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $238,410 to The Regents of the University of California, San Francisco on August 1, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). This five-year mentored career development award supports Dr. Sarah Kaufman's research into the mechanisms underlying tau protein aggregation and neurotoxicity in Alzheimer's disease and...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a Project Grant of $675,329 to Arizona State University on May 1, 2026, under the Aging Research program (CFDA 93.866) to support research on cellular pathology and biomarkers in a gene-delivered tauopathy model using aged macaque monkeys. The research extends prior work developing an innovative Alzheimer's disease (AD) and related dementias (ADRD) model based on intracortical injections of adeno-associated virus...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of California, Irvine a $2.49 million Project Grant under the Aging Research program (CFDA 93.866) for research on circuit vulnerability in entorhinal cortex tauopathy models of Alzheimer's disease. The award, effective September 15, 2025, through August 31, 2029, will fund scientific research to identify neuronal cell types vulnerable to tau pathology in the lateral and medial entorhinal cortex using two...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded Louisiana State University Health Sciences Center-Shreveport a Project Grant of $582,172 on May 13, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The grant funds a mechanistic investigation into the chronic neuropathologic interaction between viral infection and the progression of Lewy pathology and dementia, with completion...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of Illinois a $2.55 million Project Grant under the Aging Research program (CFDA 93.866) on August 11, 2025, with a completion date of July 31, 2029. This research project investigates the mechanisms by which SARS-CoV-2 infection increases the risk of vascular contributions to cognitive impairment and dementia (VCID). The research will examine how COVID-19 weakens the blood-brain barrier (BBB) through...
- Federal Grant Award Summary Baylor College of Medicine received a $3.04 million Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded August 15, 2025, with a completion date of July 31, 2029. The grant funds research investigating the relationship between SARS-CoV-2 (COVID-19) infection and the initiation and acceleration of Alzheimer's disease (AD) and related dementias (AD/RD), including Pick's disease, frontotemporal dementia, and...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Regents of the University of California, San Francisco a $136,620 Project Grant effective February 1, 2026 through January 31, 2028, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). This research project investigates the impact of pathological tau protein on neural circuit function in mouse models of progressive supranuclear...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of California, Davis a $1.72 million Project Grant (CFDA 93.853: Extramural Research Programs in the Neurosciences and Neurological Disorders) on July 15, 2026, to investigate the mechanistic relationship between SARS-CoV-2 infection and tau pathology in a rhesus macaque model of tauopathy. The three-year project, concluding June 30, 2029, will deliver research outputs designed to clarify whether prior viral infection potentiates tau-related neurodegeneration and whether pre-existing tau pathology is exacerbated by subsequent infection. The research employs two complementary non-human primate models: intranasal and intratracheal inoculation to induce SARS-CoV-2 neuroinvasion, and intracortical adeno-associated viral vector delivery to trigger tau pathology spreading through the medial temporal lobe. The grant will produce longitudinal biomarker data, high-resolution neuroimaging analyses (magnetic resonance imaging and optical coherence tomography), and postmortem neuropathological findings to elucidate the synergistic effects of viral infection and neurodegeneration. These research deliverables address a critical gap in understanding the biological mechanisms linking COVID-19 to long-term cognitive decline and Alzheimer's disease and related dementias, with potential implications for identifying therapeutic interventions and patient risk stratification.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.7m | 7/7/26 |