Project Grant RF1NS141940
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded $150,342 to the University of Washington on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds investigation of how long-term, closed-loop, epidural spinal cord stimulation affects neuropathic pain symptoms in rats with cervical spinal cord injury. The...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded The Medical University of South Carolina $226,500 on August 21, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to characterize spinal pain and non-pain pathway activity and responses in people with chronic spinal cord injury and neuropathic pain. The research will compare...
- The National Institute of Neurological Disorders and Stroke awarded Drexel University $149,190 on July 14, 2026, under CFDA 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders) to conduct research on transcutaneous spinal cord stimulation and its mechanisms for reducing spasticity following spinal cord injury. The research investigates whether transcutaneous spinal cord stimulation improves spasticity after spinal cord injury by upregulating KCC2, a chloride...
- This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279), is focused on developing novel methods for selectively stimulating nociceptors (pain receptors) and measuring the brain's nociceptive-specific response in both healthy individuals and those with the chronic pain condition fibromyalgia. The $2,314,276 award to Emory University will fund the creation of a new...
- The National Institute of Neurological Disorders and Stroke awarded the University of Pittsburgh $129,330 on June 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to support basic neuroscience research on spinal pain circuits and descending pain modulation mechanisms. The funded research develops novel ex vivo imaging platforms and transcriptomic analysis to identify spinal neurons that receive input from mu opioid receptor-expressing neurons in the rostral ventromedial...
- The National Institute of Neurological Disorders and Stroke awarded Case Western Reserve University $3,778,614 on August 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop and validate transient selective neural inhibition via photobiomodulation (TSNIP) for chronic knee pain treatment. The research integrates optimized TSNIP parameters into the COSMIIC modular platform—an FDA-qualified system already proven safe for electrical stimulation and sensing in...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $3,565,780 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to develop a groundbreaking high-frequency trans-spinal magnetic stimulation (HF-TSMS) system for the non-invasive treatment of neuropathic pain. The funded project aims to create an HF-TSMS tool that can target neural pathways involved in...
- This $2,370,000 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to develop advanced human pluripotent stem cell (HPSC) tools to create comprehensive, region-specific models for studying pain circuitry. The award to Trustees of Tufts College (Tufts University) supports three main objectives: 1) Developing scalable methods to generate region-specific sensory neurons and...
- Federal Cooperative Agreement Summary The University of Pittsburgh received a $3.24M Cooperative Agreement from the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded September 1, 2025, through August 31, 2027. This award supports the development and clinical evaluation of a fully implanted spinal cord stimulation (SCS) system designed to restore sensory sensation and alleviate phantom limb pain (PLP) in...
- The National Institute of Neurological Disorders and Stroke awarded Mayo Clinic $622,784 on July 21, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate acute and chronic repercussions of spinal cord stimulation following spinal cord injury. The research quantifies blood pressure instability after spinal cord injury, which interrupts descending autonomic regulatory signals and causes loss of consciousness, stroke,...
The National Institute of Neurological Disorders and Stroke (part of the Department of Health and Human Services National Institutes of Health) awarded Oregon Health & Science University $5.363 million on August 18, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to optimize spinal cord stimulation parameters for pain and itch management. The research investigates how epidural spinal cord stimulation engages dorsal horn circuits, specifically targeting neuropeptide Y (NPY)–expressing inhibitory neurons implicated in gating pain and itch responses. The project uses multiphoton microscopy with genetically encoded calcium indicators (jGCaMP8s) to overcome technical limitations of traditional electrophysiological approaches and characterize neuronal activity in intact tissues. The work comprises three specific aims: establishing the relationship between calcium fluorescence and neuronal action potential firing in NPY and lamina I projection neurons; identifying optimal SCS parameters that maximally activate NPY neurons while suppressing outputs in nerve-injured mice, and comparing these parameters to standard SCS in mechanical and thermal pain gating; and determining whether optimized parameters suppress pruritogen-evoked projection neuron activity. This mechanistic foundation addresses a gap in the current understanding of how SCS, a frequently used neuromodulation therapy for intractable neuropathic pain, engages specific neuronal populations. Performance occurs in Portland, Oregon, with a period of performance through July 31, 2030. The award is classified as a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.3m | 8/31/26 | ||
| Not listed | $2.0m | 8/18/26 |