Project Grant K99NS146440
- Federal Grant Award Summary The University of Pittsburgh received a $620,504 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), awarded on February 11, 2026, with a completion date of November 30, 2030. This award funds fundamental neuroscience research investigating how the brain prioritizes competing survival needs and resolves chronic pain through...
- Federal Project Grant Award Summary The University of Pittsburgh received a $9.8 million Project Grant from the National Institute of Neurological Disorders and Stroke under the Drug Use and Addiction Research Programs (CFDA 93.279) awarded on September 19, 2025, with completion targeted for August 31, 2029. This research initiative investigates biopsychosocial mechanisms underlying inter-individual differences in movement-evoked pain and functional impairment among knee osteoarthritis (OA)...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of North Carolina at Chapel Hill a $222,758 Project Grant on August 7, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to support research through July 31, 2027. The award funds a comprehensive neuroscience investigation aimed at delineating how different molecularly defined dorsal root ganglia (DRG) neuron types contribute to pain representation...
- Federal Project Grant Award Summary The University of Pittsburgh received a $188,307 Project Grant award from the National Institute on Drug Abuse under the Drug Use and Addiction Research Programs (CFDA 93.279) effective September 1, 2025, through August 31, 2029. Led by Principal Investigator Dr. Edwards, the project will develop a guided, web-based behavioral treatment intervention combining Acceptance and Commitment Therapy (ACT) for chronic pain with Mindfulness-Based Relapse Prevention...
- Federal Project Grant Award Summary The University of Pennsylvania received a $667,349 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective August 1, 2025, through June 30, 2030. This award funds research investigating state-dependent control of nociception in opioid circuits, specifically examining how pain perception is modulated by...
- Federal Project Grant Award Summary Duquesne University received a $517,494 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, effective July 1, 2025, through June 30, 2028. The award funds research to identify differentially expressed RNA splice isoforms of the transcription factor ATF3 (Activating Transcription Factor 3) that account for sex-specific...
- Federal Grant Award Summary The University of Pennsylvania received a $708,040 Project Grant awarded June 15, 2026, by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct research on distinct amygdalar neural circuits underlying pain and opioid dependence. The research project, extending through March 31, 2031, will investigate how chronic opioid exposure induces neural plasticity in brain circuits critical to pain processing...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The University of Pennsylvania a $446,875 Project Grant effective June 1, 2025, through May 31, 2027, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853). The research project focuses on generating and characterizing a novel NTRK3-FLPO knockin mouse line to enable genetic interrogation of Aβ nociceptors—a previously inaccessible population of...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded The Washington University a $1,964,283 Project Grant effective August 15, 2025, through April 30, 2030, under the Drug Use and Addiction Research Programs (CFDA 93.279). This research initiative will investigate mesolimbic dopaminergic adaptations underlying altered reward sensitivity in chronic neuropathic pain (CNP), with research to be conducted at the university's St. Louis, Missouri facility. The project...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of Pittsburgh a Project Grant of $109,062.00 under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant, effective August 7, 2025, through July 31, 2030, funds a predoctoral training program in basic neuroscience at the Center for Neuroscience at the University of Pittsburgh (CNUP). This award replaces an expired T32...
The University of Pittsburgh received a $129,330 Project Grant from the National Institute of Neurological Disorders and Stroke under the Drug Use and Addiction Research Programs (CFDA 93.279) beginning June 15, 2026, with completion expected by May 31, 2028. This award supports fundamental neuroscience research investigating spinal neural circuits involved in pain modulation and the mechanisms by which chronic stress amplifies pain processing. The research employs advanced imaging and transcriptomic techniques to identify and characterize spinal neurons that receive descending projections from mu opioid receptor-expressing neurons in the rostral ventromedial medulla, with the goal of understanding how these circuits shift toward a pro-nociceptive state in chronic pain conditions. The deliverables include novel scientific findings on the postsynaptic targets of descending facilitation from the brainstem to the spinal cord, population-level identification of spinal neurons engaged by pain modulation pathways, and characterization of conserved cell types between mouse and human neural tissues to support translational applications. The award also provides training in cutting-edge neuroscience methodologies including spatial transcriptomics, multiphoton imaging, and related advanced techniques. These research outputs are intended to advance understanding of stress-induced pain chronification and inform development of targeted therapeutic interventions for chronic pain conditions.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $129.3k | 6/5/26 |