Project Grant RF1NS140762
- Federal Project Grant Award Summary The University of Pittsburgh received a $2.35 million Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), awarded September 8, 2025, with completion targeted for June 30, 2029. The research project investigates the pathological mechanisms of blood-cerebrospinal fluid (CSF) barrier dysfunction in vascular cognitive...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded New York University School of Medicine a $6.2 million Project Grant on September 15, 2025, under the Aging Research program (CFDA 93.866) to conduct multidisciplinary research examining the relationship between peripheral immune markers and vascular contributions to cognitive decline and dementia. The research integrates biofluid biomarkers—specifically platelet aggregation, neutrophil activity, and proteomic data—with...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded $2,557,950 to The Feinstein Institutes for Medical Research under the Aging Research program (CFDA 93.866) on May 15, 2026, for research investigating the role of neurotoxic astrocytes in Alzheimer's disease (AD) pathogenesis. This R01 Project Grant, which extends through April 30, 2030, focuses on elucidating a novel molecular mechanism whereby extracellular cold-inducible RNA-binding protein (ECIRP) induces...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Leland Stanford Junior University a Project Grant totaling $122,526.00 under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award, issued on May 15, 2026, with a completion date of April 30, 2028, supports research investigating the mechanisms of Alzheimer's disease (AD) initiation and progression using novel adult...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded J. David Gladstone Institutes a Project Grant of $1,375,478 under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective September 1, 2025, through August 31, 2033. This eight-year award supports multidisciplinary research investigating neurovascular dysfunction and its role in neurodegeneration, central nervous system (CNS)...
- Federal Project Grant Award Summary Tufts Medical Center Parent, Inc. received a $616,031 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective May 5, 2026, with completion targeted for February 28, 2031. This research initiative investigates the role of arterial endothelial pannexin 1 (PANX1) channels in ischemic stroke outcomes, with...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the Regents of the University of Michigan a $633,146 Project Grant effective August 4, 2025, through July 31, 2030, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). This research initiative addresses the identification of modifiable factors associated with vascular cognitive impairment and dementia (VCID) occurring after stroke, a...
- Federal Project Grant Award Summary Albert Einstein College of Medicine received a $462,000 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective May 5, 2026 through April 30, 2028. The award funds research investigating astrocyte response to glymphatic shear forces, with the objective of quantifying how astrocyte endfeet—specialized...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded Henry Ford Health + Michigan State University Health Sciences a project grant of $431,750 under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) for research investigating a novel therapeutic strategy to treat multi-infarct dementia (MID). The award, effective May 20, 2025, through April 30, 2027, funds preclinical research utilizing...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded San Diego Biomedical Research Institute a Project Grant of $541,750 under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, effective May 15, 2026 through April 30, 2028. This award supports the discovery of novel autophagy modulators to address Alzheimer's disease and related dementias, including frontotemporal degeneration and Lewy body...
Albany Medical College received a $1.95M Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective June 1, 2026, through May 31, 2029. The award funds research investigating inflammation-resolution pathways as a therapeutic strategy to limit vascular contributions to cognitive impairment and dementia (VCID) in the context of atherosclerosis. The research will examine mechanisms of defective inflammation resolution in VCID and evaluate specialized pro-resolving mediators (SPMs), including resolvins, as potential treatment targets to modulate myeloid cell function and mitigate cognitive decline in middle-aged populations with atherosclerotic disease. The project addresses a significant gap in Alzheimer's disease and related dementias (ADRDS) treatment, as current cholesterol-lowering therapies for atherosclerosis do not adequately prevent cognitive decline despite the 2.5-fold increased dementia risk in atherosclerotic patients. The research will generate fundamental knowledge regarding SPM signaling pathways and non-resolving inflammation as a common pathophysiological mechanism linking atherosclerosis and VCID, with the goal of establishing proof-of-concept for novel therapeutic interventions that extend beyond traditional cardiovascular risk factor management.Summary of Federal Project Grant Award
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.0m | 6/3/26 |