Project Grant RF1NS138146
- This federal Project Grant award of $770,502.00, awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to understand the molecular mechanisms by which collagen IV regulates TGF-beta signaling and its role in cerebral small vessel disease (CSVD). The research will use mouse models to perform intravital imaging of the cerebral vasculature and...
- This Project Grant award of $2,549,080.00, provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), supports research to investigate the impact of SARS-CoV-2 infection on the cerebrovasculature as a risk factor for vascular contributions to cognitive impairment and dementia (VCID). The award, with a performance period from August 11, 2025 to July 31, 2029, will fund the University of Illinois to: Determine how prior SARS-CoV-2 infection influences...
- This Project Grant award for $2,398,590.00, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to investigate the role of brain microcirculation and capillary endothelial cell energetics in the development of vascular cognitive impairment and dementia (VCID) observed in Alzheimer's disease (AD) and AD-related dementias. The...
- This federal Project Grant award, issued by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $4,693,249 to the University of California, Los Angeles (UCLA) to conduct research on defining the molecular spectrum of white matter vascular lesions that drive vascular cognitive impairment and dementia (VCID). The project aims to develop a better understanding of...
- This $1,120,805 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders federal grant program (CFDA 93.853), will support research to investigate how prior SARS-CoV-2 infection may increase the risk of vascular contributions to cognitive impairment and dementia (VCID). The research aims to: Determine how prior SARS-CoV-2 infection influences blood-brain barrier...
- This Project Grant award of $427,625 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) is funding research to develop a toolbox for studying proteome plasticity in brain endothelial cells. The research aims to further understand the mechanisms of brain blood flow regulation, which is critical for addressing neurological disorders like Alzheimer's disease where disruption of...
- This Project Grant award of $5,949,022, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will fund research to identify novel therapeutic targets for treating cerebral amyloid angiopathy (CAA) and vascular contributions to cognitive impairment and dementia (VCID). The research, led by the Jackson Laboratory with sub-awards to Emory University, Rush...
- This federal Project Grant award of $2,813,759.00 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) grant program. The award supports research to investigate the role of the noradrenergic system and its integration with glutamatergic signaling in regulating neurovascular coupling, which is the process that increases cerebral blood flow to regions of high neuronal...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $431,750 to support a collaborative research project between Henry Ford Health and Michigan State University Health Sciences. The project aims to overexpress the CYP2C11 enzyme in peri-lesion astrocytes using an adeno-associated virus (AAV) vector, in order to increase cerebral...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a Project Grant of $1,375,478 under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the J. David Gladstone Institutes in California. This grant funding supports a multidisciplinary research program to study the role of neurovascular dysfunction in neurodegeneration, CNS repair, and glial cell biology. Key research activities include in vivo two-photon and super-resolution...
This federal Project Grant award of $2,353,206.00, issued by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the role of the SPAK-NKCC1 protein complex in the choroid plexus and its contribution to blood-CSF barrier dysfunction in vascular contributions to cognitive impairment and dementia (VCID). The research aims to fill the knowledge gap on the pathological mechanisms of blood-CSF barrier breakdown in Alzheimer's disease and VCID. Key products and services to be delivered include conducting studies using a mouse VCID model to examine the effects of chronic cerebral hypoperfusion on the choroid plexus, including evaluating changes in tight junction proteins, SPAK and NKCC1 phosphorylation, and NF-kB activation. The award has an initial period of performance from September 8, 2025 to June 30, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.4m | 9/5/25 |