Project Grant RF1NS135026
- Federal Project Grant Award Summary The University of Connecticut Health Center received a $471,861 project grant award dated March 17, 2026, from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award supports a two-year research project through February 28, 2028, focused on developing transposon-mediated genetic manipulation techniques to investigate...
- This federal Project Grant award, issued by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $4,693,249 to the University of California, Los Angeles (UCLA) to conduct research on defining the molecular spectrum of white matter vascular lesions that drive vascular cognitive impairment and dementia (VCID). The project aims to develop a better understanding of...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $520,025 to the University of Connecticut Health Center on July 1, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop next-generation RNA inhibitors for ischemic stroke therapy. The research focuses on developing peptide nucleic acid (PNA) analogs, particularly gamma (γ) PNA-based microRNA-141-3p (mir-141-3p)...
- Federal Project Grant Award Summary The University of Connecticut Health Center received a $680,941 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, effective July 7, 2025, through June 30, 2030. This award funds investigator-initiated basic and translational research examining the unique role of the ASPM (assembly factor for spindle...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of Pittsburgh a $2.35 million Project Grant on September 8, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853). The award, which extends through June 30, 2029, funds research investigating the role of the SPAK-NKCC1 protein complex in blood-cerebrospinal fluid (blood-CSF) barrier dysregulation associated with vascular...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) in the amount of $431,750 aims to isolate and characterize peptide ligands targeting vascular endothelial cells (VECs) in young versus aged mice in vivo and senescent versus non-senescent murine VECs in vitro. The primary objectives are to enhance the understanding of molecular mechanisms and age-related pathologies associated with vascular dysfunction during aging. The project seeks to...
- This Project Grant award for $2,398,590.00, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to investigate the role of brain microcirculation and capillary endothelial cell energetics in the development of vascular cognitive impairment and dementia (VCID) observed in Alzheimer's disease (AD) and AD-related dementias. The...
- Federal Project Grant Award Summary Vanderbilt University Medical Center received a $1.47 million Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded January 1, 2026, with completion targeted for December 31, 2030. The grant supports research investigating mechanistic links between endothelial cell aging and dementia, with primary deliverables centered on developing a novel human induced pluripotent stem cell (iPSC)-derived endothelial cell model of...
- Federal Grant Award Summary The University of Texas Health Science Center at Houston received a $650,533 Project Grant award from the National Institute on Aging (Aging Research program, CFDA 93.866) effective February 1, 2026, through January 31, 2031. This five-year research initiative investigates the contribution of intramural von Willebrand Factor (VWF) to cerebrovascular dysfunction in amyloidosis, with particular focus on Alzheimer's disease and cerebral amyloid angiopathy. The research...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded Massachusetts General Hospital $470,786 under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program on May 15, 2025, with completion targeted for March 31, 2030. This Project Grant supports investigator-initiated research examining the mechanisms linking aging, immune dysfunction, and vascular contributions to cognitive impairment and dementia...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under CFDA program 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders, provides $1,583,383 to the University of Connecticut Health Center (UCHC) for a research project titled "Regulation of FLT 1 Splicing by Fibronectin and Integrin Signaling During Aging." The research aims to elucidate the molecular mechanisms by which age-related vascular changes, including increased extracellular matrix protein fibronectin and vascular stiffening, lead to increased production of the VEGF antagonist soluble FLT1. This process is hypothesized to contribute to vascular rarefaction and cognitive impairment. The project includes in vitro experiments to characterize the splicing regulation of the FLT1 gene, as well as in vivo mouse studies to test this hypothesis and identify potential therapeutic targets. UCHC has subcontracted a portion of the in vivo experiments to Yale University. The award period runs from Sep 19, 2023 to Aug 31, 2026.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.6m | 9/18/23 |
GrantNumber | Description | Subgrantee | Prime Award | Dollars Obligated | Updated At |
|---|---|---|---|---|---|
UCHC7180069309S | Yale Univ | Project Grant RF1NS135026 | $853.2k | 1/24/24 |