Unique role of aspm in development of large and folded cerebral cortex

Active Project Grant Awarded Last action

Award ID
R01NS140441
Recipient
Awarding agency
Obligated
$1,317,353

Award facts

Completion date 26% complete
Place of performance
Farmington, CT 06030, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Neurodevelopmental disorders affecting the large and folded (gyrencephalic) human cerebral cortex require disease mechanisms that are robust in humans but insignificant in mice. For example, loss of aspm (assembly factor for spindle microtubules) in humans causes severe microcephaly with 50-75% reduction in cortical volume, simplified gyri, epilepsy, and intellectual disability. In contrast, aspm KO mice show

Transactions

Action Obligated Date
Amendment $636,412
Original award $680,941

Subawards

Subrecipient Amount Awarded
Regents Of The University Of Michigan The University of Michigan PI will supervise and execute the portion of the project dedicated to profiling the spatial transcriptome of the tissue sections… $91,481
Northwestern University The Smith Laboratory at Northwestern will perform all the ferret injections/surgeries in Feinberg CCM facility, as well as brain tissue harvesting, and tissue… $189,528
Regents Of The University Of Michigan The Univ of Michigan will supervise and execute the portion of the project dedicated to profiling the spatial transcriptome of the tissue sections provided by… $93,015

Quick answers

Who received award R01NS140441?

R01NS140441 was awarded to University Of Connecticut Health Center by National Institute of Neurological Disorders and Stroke (National Institutes of Health) on July 7, 2025.

How much is award R01NS140441 worth?

$1,317,353 has been obligated on R01NS140441.

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