The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Trustees of Columbia University in the City of New York, doing business as the Health Sciences Division, a $2,554,313 federal Project Grant under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372). The grant, which runs from Sep 1, 2023 to Aug 31, 2026, will support research to determine if targeted in vivo manipulations of local circuit control mechanisms in the hippocampus can enable the specific generation and allocation of behaviorally relevant neural representations. The project will use innovative techniques like all-optical plasticity induction, in vivo calcium imaging, optogenetics, and computational modeling in the mouse hippocampus to examine the role of feedback inhibitory, recurrent excitatory, and cell-intrinsic retrograde local circuit control mechanisms in scaling single-cell place cell induction to multi-cellular ensembles. A sub-award totaling $XXX,XXX was provided to The Leland Stanford Junior University to support joint oversight, coordination, and specialized experiments and modeling related to the project.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $2.6m | 8/23/23 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
1GG01890301S | The Leland Stanford Junior University | Project Grant RF1NS133381 | $404.9k | 3/10/24 |