This Project Grant from the National Institutes of Health's National Institute of Neurological Disorders and Stroke will fund the development of advanced tools for genetically targeted all-optical electrophysiology in behaving mice. Specifically, the $4,381,836 award to President and Fellows of Harvard College, doing business as Harvard University, will support efforts to co-develop two-photon excitable genetically encoded voltage indicators and a new type of two-photon voltage-imaging...
This Project Grant award of $259,095 from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), aims to develop an advanced optical imaging system capable of capturing the full electrical dynamics of thousands of neurons in the cortex and hippocampus of awake, behaving rodents. The project will leverage a combination of structured one-photon excitation and light field detection to achieve high-speed volumetric imaging of genetically encoded voltage...
This three-year Project Grant from the National Institutes of Health's National Institute of Mental Health will fund $2,668,158 to integrate structural and functional datasets to understand how neural structure enables function in the mouse visual cortex. The Regents of the University of California, San Francisco will analyze the largest calcium imaging dataset collected to date from an entire column in mouse primary visual cortex, comprising volumetric 2-photon and 3-photon imaging recordings...
This $1,999,635 project grant from the National Institutes of Health's National Institute of Neurological Disorders and Stroke (NIH NINDS) will fund research into understanding feedforward and feedback signaling between neuronal populations. The grant was awarded to Albert Einstein College of Medicine on March 15, 2022 for a period ending February 28, 2025. The project aims to advance understanding of how feedforward and feedback signaling work together in the visual system by analyzing...
Purdue University was awarded a $1,304,216 Project Grant by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) to develop and test a new platform for high-density 3D electrophysiology and two-photon calcium imaging in freely moving animals. The goal is to enable simultaneous recording of millisecond electrical dynamics and spatial mapping of neural circuit activity during natural behaviors to better understand how the brain processes...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $187,831 Project Grant (CFDA #93.286 - Discovery and Applied Research for Technological Innovations to Improve Human Health) to the University of California, Davis to develop a miniature two-photon microscope that can simultaneously perform high-resolution calcium imaging and optogenetic manipulation of neural activity in freely-behaving mice. The project will integrate innovative beam forming techniques into a...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372), will fund the development and validation of a family of genetically encoded, fluorescent "chemogenetic" voltage sensors for in vivo brain imaging. The 3-year, $2,329,605 grant to Brown University aims to create improved far-red and two-photon compatible...
This $1,761,170 project grant from the National Institute of Neurological Disorders and Stroke will support research into feedback and feedforward gating of sensory signaling through timing in the thalamocortical loop. The grantee, Georgia Tech Research Corporation, will utilize optogenetic and electrophysiological techniques to precisely measure and manipulate elements of the thalamic-cortical circuit in the whisker somatosensory pathway of awake mice. Specifically, the research aims to...
The National Institutes of Health (NIH) awarded a $1,385,000 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to the Allen Institute, a non-profit research organization, to develop novel techniques for measuring the input-output operations of individual neurons in the mouse cortex. The project aims to overcome challenges in understanding how neurons in the mammalian brain transform their synaptic inputs into outputs, which is critical for designing effective brain-machine...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $273,254 to the University of California, San Diego (UCSD) to conduct research on the neural mechanisms underlying active sensory processing, particularly in the context of whisker-based touch in mice. The funded research aims to develop a theoretical model and make empirical...