Project Grant RF1NS082730

Award Date 6/1/25
Completion Date 5/31/27
Dollars Obligated $1.6M
Funding Federal Agency
National Institute on Aging
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Illinois, USA
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This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research into the role of local protein synthesis in the development of tau pathology and neurodegeneration associated with Alzheimer's disease. The $1,147,300 grant awarded to Wayne State University will fund a 5-year project to investigate how pathogenic forms of the tau protein interfere with dendritic protein synthesis, which may contribute to the early synaptic dysfunction seen in...
This federal Project Grant award of $816,661 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a research initiative by the Regents of the University of California, San Francisco (UCSF) to comprehensively map the impact of tau pathology on the proteome, which is expected to be mediated in part through disruptions in mRNA splicing. The research leverages AD mouse models and human iPSC tauopathy models to discover protein drivers of tauopathy and validate such drivers in...
The National Institute on Aging (NIA) awarded a $773,816 Project Grant (CFDA 93.866 - Aging Research) to the University of California, Irvine to conduct a comprehensive study on the molecular mechanisms underlying aberrant protein accumulation in Alzheimer's disease-related tauopathies. The project aims to generate cell-type-specific atlases of misprocessed RNAs and proteins in mouse models and human brain tissues to identify new pathways and protein interaction networks involved in...
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This $1,100,000 Project Grant award from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) supports research by the University of Texas Medical Branch at Galveston (UTMB) to investigate the mechanisms of pathological tau protein spreading in Alzheimer's disease. The project aims to determine how amyloid-beta oligomers modulate the binding and internalization of toxic tau oligomers at synapses, which is a key component of the trans-synaptic spreading of tau...
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