This $1,592,854 project grant was awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Illinois to investigate the molecular mechanisms underlying tau protein dysfunction in neurodegenerative tauopathies, including Alzheimer's disease and related dementias. The overarching goal is to understand how disease-related changes in tau conformation and post-translational modifications disrupt tau's normal scaffolding functions and lead to dysregulation of key signaling pathways, ultimately causing neuronal dysfunction. The 2-year project will define the effects of specific tau modifications on its ability to regulate kinases and phosphatases, evaluate how disease-associated tau mutations impact these regulatory mechanisms, and characterize the molecular basis for tau-mediated activation of CK2 and JNK signaling pathways. These studies aim to elucidate the physiological roles of tau in neuronal development and provide new insights into the pathogenic processes underlying tauopathies.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $1.6m | 5/30/25 |