This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), will provide $2,565,783 to Oregon Health & Science University (OHSU) from September 1, 2023 to August 31, 2026 to develop novel genetically encoded sensors and actuators for monitoring and manipulating neuromodulatory signaling activities in the brain at the cellular and circuit levels. The project aims to enable large-scale in vivo...
The National Institute of Mental Health awarded a three-year Project Grant totaling $3,618,976 to the University of California, Los Angeles under the Mental Health Research Grants program (CFDA 93.242) to develop in situ single-cell multi-omic and morphological profiling methods for mammalian brains. Specifically, the university will work to design photonic-indexing sequencing strategies to spatially barcode tissue with single-cell resolution, integrating techniques such as PI-ATAC-seq and...
The Scripps Research Institute was awarded a $4.6 million project grant from the National Institute of Mental Health to develop novel tools for molecular profiling of brain cell types. The grant is part of NIMH's Mental Health Research Grants program (CFDA 93.242), which supports basic and clinical research to transform the understanding and treatment of mental illnesses. Under the award, Scripps will expand its RIBO-STAMP technology to enable comprehensive measurement of translational...
This $742,484 federal Project Grant award from the National Institute of Mental Health (NIMH) under CFDA Program 93.242 - Mental Health Research Grants will support research to characterize a genetic mouse model and delineate its function in the brain. The project aims to obtain multi-omic single-nucleus RNA sequencing and ATAC-seq data to analyze and correlate gene expression and chromatin modifications in the mouse brain at three critical developmental time points and two key brain regions....
This $2,694,945 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research to identify cellular phenotypes related to the etiology, pathophysiology, and symptomatology of schizophrenia. The Lieber Institute for Brain Development, a non-profit medical research organization, will utilize induced pluripotent stem cell (iPSC) technology to model the cumulative cellular effects of common schizophrenia genetic...
This $1.8 million project grant from the National Institutes of Health's National Institute of Mental Health will fund the development of high-throughput methods for measuring synaptic connectivity at single-cell resolution in the cerebral cortex. Over a three-year period from September 2022 through August 2025, The Broad Institute, Inc. will pursue viral, functional, and molecular approaches to map local cortical circuitry. These include optimizing rabies-based trans-synaptic tracing for...
The National Institute of Mental Health (NIMH) awarded a $1,737,000 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Max Planck Florida Corp, doing business as Max Planck Florida Institute For Neuroscience. The 3-year project, starting September 1, 2024, aims to systematically investigate the synaptic energy logistics that enable the brain to process and store information. Specifically, the research will discover novel regulators that dictate the flexibility of...
The National Institute of Mental Health (NIMH) awarded a $911,929 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the Scripps Research Institute in La Jolla, CA on September 5, 2024. The grant will fund a research project titled "Scalable Functional Analysis of Neuropsychiatric Risk Genes with Spatially Integrated In Vivo Perturb-Seq." The project aims to combine high-content in vivo genetic screening with whole brain cytoarchitecture spatial information to bridge the...
The National Institute of Mental Health (NIMH) awarded a $392,500 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the University of California, Irvine to study the developmental origins of mental illness. The 5-year grant, which begins on January 1, 2025, will test the hypothesis that early life adversity impacts the structure and function of the hypothalamus, a brain region that integrates brain and bodily states, thereby contributing to maladaptive behaviors underlying mental...
The federal Project Grant award R01MH134827, in the amount of $692,043, was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The grant supports research to investigate the role of presynaptic homeostatic plasticity, a physiological process that stabilizes neural function, and its potential links to the cause and severity of mental health disorders such as autism and intellectual disability. The research conducted under this...