The National Institute of Mental Health (NIMH) awarded a $911,929 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the Scripps Research Institute in La Jolla, CA to conduct scalable functional analysis of neuropsychiatric risk genes using spatially integrated in vivo perturb-seq technology. This 5-year research project aims to comprehensively map the functions of 72 high-confidence autism spectrum disorder and neurodevelopmental delay (ASD/NDD) risk genes in the neocortex and...
The National Institute of Mental Health awarded a three-year Project Grant totaling $3,618,976 to the University of California, Los Angeles under the Mental Health Research Grants program (CFDA 93.242) to develop in situ single-cell multi-omic and morphological profiling methods for mammalian brains. Specifically, the university will work to design photonic-indexing sequencing strategies to spatially barcode tissue with single-cell resolution, integrating techniques such as PI-ATAC-seq and...
The National Institute of Mental Health awarded Oregon Health & Science University a $4,214,208 project grant under the Mental Health Research Grants program (CFDA 93.242) for the period of August 1, 2022 through July 31, 2025. The grant funds development of a new technique called SLIDE-SBARRO to generate quantitative models of synaptic networks in mouse striatum through spatially-resolved single-cell RNA sequencing of hundreds of thousands of cells. The aims are to create an...
This $7.6 million project grant from the National Institute of Mental Health, part of the Department of Health and Human Services, will fund research under the Mental Health Research Grants program (CFDA 93.242). Baylor College of Medicine will lead simultaneous high-throughput functional, transcriptomic, and connectivity profiling of neurons in the mouse visual cortex. The research aims to characterize the complex functional properties of neurons using in vivo two-photon imaging combined with...
This $2,220,017.04 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support a large-scale, single-cell characterization of the molecular and cellular networks underlying mood regulation circuitry in major depressive disorder (MDD). The key products and services to be delivered include: 1) identifying transcriptomic changes associated with MDD at the single-cell level across 800 human postmortem brain...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $2,415,243 to The Broad Institute, Inc. to develop a scalable, cloud-based framework for multi-modal mapping across single neuron omics, morphology, and electrophysiology. The framework aims to enable integrative, data-driven characterization of brain cell types, leveraging federated Brain Initiative resources and community engagement....
The National Institute of Mental Health (NIMH) awarded a $908,174 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the Lieber Institute for Brain Development to conduct research on understanding the etiology and pathophysiology of schizophrenia. The 5-year grant (8/7/2024 - 4/30/2029) will utilize induced pluripotent stem cell (iPSC) technology to model the cellular effects of common schizophrenia genetic risk variants. The research will involve phenotypic discovery on cortical...
This $2,576,654 Project Grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support the development of a cloud-based software platform and advanced computational pipelines to harmonize and integrate spatial transcriptomics data for the construction of a spatially resolved brain atlas. Key objectives of the 3-year project include: 1) Creating a cloud-based platform to standardize the analysis and visualization of...
This $21.4 million cooperative agreement from the National Institute of Mental Health will fund research to identify gene regulatory elements that can target and manipulate specific neuronal cell types and brain circuits across species, including in human organoids. Awarded on September 1, 2022 to the Broad Institute, Inc. with completion by August 31, 2025, the funding supports the Mental Health Research Grants program. The Broad Institute and collaborators at Harvard University will profile...
The National Institute of Mental Health (NIMH) awarded a $2,490,741 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to President and Fellows of Harvard College (Harvard University) to develop the THERMAL-PLEX method. This fluidic-free, rapid sequential imaging technique enables multiplexed analysis of RNA and protein in brain tissues, providing critical insights into the spatial organization of molecular targets. The 3-year project aims to remove complex and slow...