Project Grant RF1AG094985
- This $880,000 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a study to examine the effects of daily stress, sleep, and sex hormones on accelerated vascular aging in premenopausal midlife women. The 2-year study, starting November 2024, will investigate how emotional reactivity to daily stressors and sleep variability contribute to vascular dysfunction prior to menopause, and how these factors interact with changes in estradiol levels. The...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to identify which aspects of daily stress processes - frequency, severity, and affective reactions - are linked with heightened inflammatory biomarkers in older adults, and the extent to which these associations vary between men and women. The award of $148,500 will be used by the primary awardee, South Dakota State University, to conduct this research using data from the Einstein Aging Study. The...
- The National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), awarded a $245,434 project grant to Wake Forest University Health Sciences (WFUHS) to examine the associations between early and later-life stress on later-life cognition and plasma biomarkers of Alzheimer's disease and related dementias (ADRD). The study aims to investigate how stress experienced across the lifespan, as well as perceived psychological stress, may impact cognitive decline and...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $699,344 to Albert Einstein College of Medicine to investigate the impact of surgical stress on age-related changes and resilience, with a focus on sex differences. The project aims to quantify the spatial, temporal, and sex-dependent effects of surgical stress on aging hallmarks and determine how resilience may modulate these relationships. The 2-year award period runs from September 1, 2025 to...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to gain a mechanistic understanding of the role of cellular senescence in the pathogenesis of Alzheimer's disease (AD). The $460,625 grant will fund research at the University of Massachusetts Medical School to dissect the separate P53/P21 and P16 senescence pathways and their functional consequences in AD using human induced pluripotent stem cell-based models. The 2-year project will produce...
- This Project Grant award of $549,128 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports a study to investigate the relationship between early-life factors, telomere length, and the development of subclinical atherosclerosis. The research team at The Research Foundation For The State University Of New York (RF SUNY) will measure telomere length from birth to young adulthood and assess its association with growth, air pollution exposure, and...
- This federal Project Grant award of $3,355,744 from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), will fund a longitudinal study on the intergenerational impact of trauma exposure from the 9/11 attacks. The study aims to conduct a 4th wave of data collection on a cohort of 9/11-exposed parents and their indirectly exposed children to understand the long-term mental, physical, and cognitive effects of disaster experiences, as well as the role of aging on...
- This federal Project Grant award of $438,625.00 from the National Institute on Aging (CFDA 93.866 Aging Research) to Brown University aims to study how the cellular senescence phenotype changes over time and develop technology to track the duration of cells in senescent states. The key objectives are to (1) examine how the senescence phenotype, including the senescence-associated secretory phenotype (SASP), evolves from early to deeper states, and (2) advance a multi-symbol molecular recorder...
- The National Institute on Aging, through the Aging Research Federal Grant Program (CFDA 93.866), awarded $450,250.00 to George Washington University on August 15, 2025 to conduct a project titled "The Impact of Early Life Stress on Vascular Aging". The project aims to explore how early life stress and adversity contribute to cardiovascular disease risk in adulthood using a preclinical mouse model. Specifically, the project will (1) evaluate the effects of early life adversity on...
- This $333,116 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to understand the impact of telomere dysfunction and natural aging on the intestinal stem cell niche. The goal is to examine how aging and acute telomere failure suppress stromal niche support for intestinal stem cells, contributing to intestinal phenotypes associated with aging and telomeropathies like dyskeratosis congenita. The research will utilize a novel mouse...
This Project Grant award of $3,304,237 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support a 40-year longitudinal study examining the links between early life adversity, cumulative life stress, and cellular aging in midlife women and their offspring. The study aims to assess which aspects of life course stress, including childhood, midlife, and cumulative stress, are associated with accelerated cellular aging at age 50. The study will repeat assessments of cell aging markers, such as telomere length and epigenetic clocks, as well as metabolic syndrome, in 624 women from the National Heart, Lung, and Blood Institute Growth and Health Study cohort and their children. The award has a performance period from September 15, 2025 to September 14, 2029 and will be conducted by the Regents of the University of California, San Francisco, a prominent academic medical center and research institution.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.3m | 9/12/25 |