Project Grant R01AI184716
- The University of Southern California received a $162,486 Project Grant from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to engineer B cells for enhanced HIV control. The 4.5-year project, which began on February 1, 2025, aims to develop an approach to provide necessary T cell help and produce broadly neutralizing antibody-engineered B cells that would be functional in people living with HIV. Key objectives include...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support research on manipulating the DNA damage response and proteome on viral genomes during herpes simplex virus (HSV) infection. The $651,832 award, with a project period from November 2024 to October 2029, will enable researchers at The Children's Hospital of Philadelphia to conduct a multi-modal proteomic...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $3,047,991 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Rector & Visitors of the University of Virginia. The grant, awarded on September 12, 2025, will fund research to investigate the molecular basis for paired receptor signaling in antiviral natural killer (NK) cells during murine cytomegalovirus (MCMV) infection. The research aims to delineate how NK cell receptor...
- This $536,871 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to identify small molecule inhibitors against critical components of arenaviruses, which cause severe hemorrhagic fevers. The proposed studies aim to use machine learning and molecular screening to identify pan-reactive inhibitors targeting the arenavirus surface glycoprotein and RNA polymerase...
- The University of Southern California (USC) received a $623,986 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program. The funding supports a research project to study the genetic and molecular mechanisms that enable fungi, specifically the opportunistic pathogen Saccharomyces cerevisiae, to persist and cause infections in mammalian hosts. Key objectives include: Identifying causal...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $147,486 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The New York Structural Biology Center, Inc. (NYSBC) to conduct research on the structural diversity and functional implications of viral RNA translation initiation elements, known as internal ribosome entry sites (IRES). The research aims to define the structural heterogeneity of HCV-like IRES elements across multiple...
- The University of Chicago was awarded a $295,276 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), to computationally investigate key morphological transitions in the HIV-1 life cycle. The research aims to develop a mechanistic understanding of viral assembly, maturation, and uncoating processes, which could aid in the design of new antiretroviral therapies targeting...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $2,937,578 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of North Carolina at Chapel Hill. The grant, awarded on August 18, 2025, supports the development of an ACE2 immunodecoy therapy for long-lasting immunoprophylaxis against SARS-CoV-2 variants and other zoonotic coronaviruses that target the human ACE2 receptor. The project aims to optimize the linkage...
- The federal Project Grant award R21AI185033 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the role of the APOBEC3B enzyme in the innate immune response against RNA viruses such as SARS-CoV-2, HIV-1, and Hepatitis B. The $228,435 award, effective January 2, 2025 through December 31, 2026, will fund research at the University of California, Irvine to identify novel...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $3,323,410 Project Grant under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) to Georgia State University Research Foundation Inc. to advance the development of inhibitors targeting seasonal and pandemic influenza viruses. The project aims to progress preclinical development and assemble an investigational new drug package for oral antiviral therapeutics, including a novel pyrimidine...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $831,235 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Southern California (USC) to explore a key nucleotide synthesis enzyme as a potential target for developing broad-spectrum antiviral therapies. The project, led by Co-PIs Pinghui Feng and Chao Zhang, aims to genetically interrogate the enzyme's role in viral immune evasion and metabolic reprogramming during infections by SARS-CoV-2, influenza virus, and herpes simplex virus. The researchers will collaborate with a structural biologist to optimize small-molecule inhibitors of the target enzyme, with the goal of depleting nucleotide supplies and restoring antiviral immune responses to impede viral replication across multiple pathogens. The project will run from August 2025 to July 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $831.2k | 8/21/25 |