This federal Project Grant award, valued at $2,399,431 and effective August 1, 2024, is funded by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866). The objective is to develop a digital cognitive health resource based on the Boston University Alzheimer's Disease Research Center (BU ADRC) cohort. The grant will leverage the BU ADRC's extensive longitudinal data, including vascular risk factors, biomarkers, and neuropsychological tests, to collect concurrent...
This federal Project Grant award from the National Institute on Aging (NIA), under the Aging Research grant program (CFDA 93.866), provides $146,922 to The Trustees of Columbia University in the City of New York to support research on the impact of Alzheimer's disease on genetic signatures of hippocampal memory traces. The key objectives of this 2-year project are to: 1) use cutting-edge labeling techniques and single-nuclear RNA sequencing to characterize the transcriptional profiles of...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,018,778 to The Lieber Institute for Brain Development (LIBD) to generate spatially-resolved, transcriptome-wide gene expression profiles of the human dentate gyrus across the lifespan. The project aims to characterize developmental and age-related changes in gene expression within specific subregions of the hippocampus, a critical brain structure involved in learning, memory, and...
This Project Grant award is funded by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866). The $2,319,456 award will support the University of California, San Diego in developing brain organoid models and leveraging multiomics techniques to investigate the mechanisms underlying Alzheimer's disease (AD) onset and progression. The key products and services to be delivered include: Derivation of 6 isogenic mutant and 3 mutant-corrected human induced...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $468,000.00 to the University of Texas Health Science Center at Houston (UTHealth) to uncover cognitive resilience factors and identify potential synergistic drug combinations that may enhance resilience in Alzheimer's disease (AD). The key objectives are to: 1) Develop an interpretable deep learning framework, called Interpretable Generative Transcriptional Program (IGTP), to model cognitive...
This $126,956 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research into generating new neurons in the aging adult brain. The principal investigator will leverage single-cell spatial transcriptomics to identify the mechanisms underlying glia-to-neuron identity conversion, with the goal of generating functional replacement neurons in mouse models of Huntington's disease and frontotemporal dementia. Key collaborators include experts in...
This is a Project Grant awarded by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866). The $459,076 award, with a performance period from August 1, 2024 to July 31, 2026, will be used by Trustees of Boston University to conduct research aimed at identifying early transcriptional and pathological changes in vulnerable brain regions during the prodromal stage of Alzheimer's disease (AD). The key objectives are to: 1) profile all cell types and...
This $842,114 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to systematically investigate the molecular mechanisms of brain senescence in different molecular subtypes of Alzheimer's disease (AD). The multidisciplinary research team, led by the Icahn School of Medicine at Mount Sinai, will utilize advanced multi-omics techniques, including single-cell RNA sequencing and spatial transcriptomics, to characterize the heterogeneity of senescent...
This Project Grant award under the National Institute on Aging's Aging Research Program (CFDA 93.866) provides $2,201,136.00 to The Trustees of Columbia University in the City of New York to develop a comprehensive statistical framework for understanding the genetic architecture of Alzheimer's disease (AD) and related dementias. The project aims to leverage large-scale biobanks and electronic health records to systematically study the age-dependent and cross-phenotype genetic factors...
This federal Project Grant award, funded by the National Institute on Aging (part of the Department of Health and Human Services) under the Aging Research program (CFDA 93.866), is focused on evaluating a novel therapeutic approach to target neuroinflammation for protecting against brain aging and Alzheimer's disease-related pathology. The $281,962 award, with an end date of June 30, 2026, will support a series of preclinical studies in aging wild-type mice and transgenic mouse models of amyloid...