This federal Project Grant award of $794,341.00, provided by the National Institute on Aging (NIA) under the Aging Research (CFDA 93.866) program, is funding research to investigate the mechanistic roles of cellular senescence and blood-brain barrier dysfunction in mediating pathogen-induced Alzheimer's disease (AD) progression. The key goals are to leverage experimental mouse models, molecular characterization of endogenous retrovirus RNA sensing, and human iPSC models to elucidate how...
The University of Illinois has been awarded a $1,870,822 Project Grant from the National Institute on Aging's Aging Research program (CFDA 93.866) to develop new super-resolution fluorescence microscopy techniques. The goal is to achieve ultra-high resolution imaging of native amyloid-alpha receptors (AMPARs) in brain slices to study synaptic plasticity in both healthy and tauopathy conditions. The research will utilize multi-color imaging and digital image reconstruction methods to isolate...
The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $472,695 project grant to 3D Bioanalytix, Inc. to develop a blood-based diagnostic test for early detection and differentiation of neurodegenerative diseases such as Alzheimer's and Parkinson's. The project leverages the company's Covalent Protein Painting (CPP) platform technology to detect and identify misfolded protein aggregates that characterize these diseases. This novel...
The National Institute on Aging (NIA), part of the Department of Health and Human Services National Institutes of Health, awarded a $3.37 million Project Grant to The University of Texas at Arlington to develop an individualized deep connectome framework for Alzheimer's disease and related dementias (ADRD) analysis. The three-year grant, awarded on August 18, 2022 under the NIA's Aging Research program (CFDA 93.866), will support research to discover and identify individualized...
The National Institute on Aging (NIA) awarded a $433,125 project grant under CFDA Program 93.866 (Aging Research) to the Regents of the University of California at Riverside (UC Riverside). The award will fund a 2-year research project to use novel magnetic resonance imaging (MRI) and spectroscopy (MRS) techniques to characterize age-related neuroinflammation and its relationship to memory performance. Key objectives include: Testing whether older age is associated with higher MRS-derived...
This $4.46 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866) to develop a new in vivo magnetic resonance imaging biomarker for early detection of Alzheimer's disease neurodegeneration. Specifically, the awardee, Washington University, will utilize quantitative gradient recalled echo MRI techniques to identify two types of hippocampal tissue in preclinical and mild...
This Project Grant award of $812,030, awarded by the National Institute on Aging (NIA) under the Aging Research (CFDA 93.866) program, aims to develop and optimize non-invasive imaging biomarkers to track neuroinflammation in the early stages of Alzheimer's disease (AD). The key products and services to be delivered include: Investigating the relationship between astrocytic acetate metabolism and astrocyte reactivity in an AD model using deuterium-based magnetic resonance spectroscopy...
This Project Grant award from the National Institute on Aging (NIA), under the Aging Research (CFDA 93.866) program, will provide $794,981 to the University of California, San Diego (UCSD) to investigate the use of blood-brain barrier (BBB) permeability and brain microstructure as biomarkers for predicting and monitoring amyloid-related imaging abnormalities (ARIA) and treatment outcomes in Alzheimer's disease patients prescribed anti-amyloid immunotherapies. The 5-year project will integrate...
This $4.49 million project grant from the National Institutes of Health's National Institute on Aging will fund research at The Washington University to investigate the relationship between amyloid plaque deposition, cellular metabolic dysfunction, and functional brain organization in Alzheimer's disease (AD) mice models. Over three years, the researchers will use multi-photon fluorescence lifetime imaging microscopy, multi-parametric photoacoustic microscopy, and wide-field optical imaging to...
The National Institutes of Health's National Institute on Aging awarded a $4.7 million Project Grant to the University of California, Davis under the Aging Research program (CFDA 93.866) to investigate neuropathogenesis in the interoceptive-allostatic network as part of an animal model of early Alzheimer's disease pathogenesis. The grant will fund detailed neuroimaging and histological analyses of the brain network responsible for generating and regulating affect in rhesus monkeys administered...