The National Institute on Aging (NIA) awarded a $452,561 Project Grant (CFDA 93.866 - Aging Research) to Trustees of Boston University's Medical Campus to conduct research on non-invasive in-vivo blood-brain barrier (BBB) imaging and its relationship to apolipoprotein E (APOE) genotype and white matter aging in a minority population. The project aims to use a novel magnetic resonance imaging (MRI) technique called multi-delay arterial spin labeling (ASL) with T2 preparation to measure subtle...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to investigate the mechanisms leading to amyloid-related imaging abnormalities (ARIA), such as cerebral edema and microhemorrhages, that can occur following anti-amyloid immunotherapy for Alzheimer's disease. The $766,133 award, effective January 1, 2025 through November 30, 2029, will fund research at the University of Texas Health Science Center at Houston to: Determine the elimination pathway and...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $3,845,311 to the University of California, San Diego (UCSD) to investigate early determinants of Alzheimer's disease (AD) using age-equivalent neurons derived from mild cognitive impairment (MCI) patients. The overarching goal is to better understand the early trajectory of MCI and AD pathogenesis by leveraging patient-derived induced neurons (iNs) that capture genetic risk factors and...
This Project Grant award of $3,929,011, provided by the National Institute on Aging (NIA) under the Aging Research (CFDA 93.866) program, is funding a longitudinal, multimodal neuroimaging study to elucidate the role of neuronal dysfunction and hyperexcitability in the early biological progression of Alzheimer's disease. The study aims to identify the earliest manifestations of neural circuit hyperexcitability that predict the accumulation of tau protein and cognitive deficits in individuals...
This Project Grant award, totaling $437,875.00, was provided by the National Institute on Aging (NIA) under the Aging Research (CFDA 93.866) federal grant program. The award will fund research at the University of California, San Diego (UCSD) to generate a comprehensive atlas of neurovascular protein lifetimes in health, aging, and a tauopathy-based model of Alzheimer's disease. The key objectives are to: 1) employ stable isotope labeling, vessel isolation, and mass spectrometry to quantify...
This Project Grant award from the National Institute on Aging (NIA) under CFDA 93.866 Aging Research program provides $622,401 to the University of Southern California (USC) to conduct research on causal modeling of brain biomarker changes related to Alzheimer's disease and related dementias (ADRD). The project aims to: 1) fit novel deep learning models to predict cerebrospinal fluid and PET-derived amyloid load from diffusion MRI data in symptomatic vs. pre-symptomatic individuals; 2)...
The National Institute on Aging (NIA) awarded a $1,783,700.00 Project Grant under the Aging Research program (CFDA 93.866) to the University of Illinois to develop novel blood-brain barrier permeable multimodal imaging agents for the diagnosis of neurodegenerative diseases, with a focus on Alzheimer's disease and related dementias. The 3-year grant aims to employ organic and inorganic chemical design principles to generate diagnostic agents capable of detecting protein aggregation,...
The National Institute on Aging (NIA) awarded a $772,581 Project Grant (CFDA 93.866) to the University of California, San Diego (UCSD) to investigate the role of the transcription factor SOX18 in neurovascular dysfunction associated with Alzheimer's disease. The project aims to examine how downregulation of SOX18 in brain endothelial cells affects angiogenesis and blood-brain barrier function, and determine if modulating SOX18 can alter the disease course in Alzheimer's mouse models. UCSD is...
This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $4,638,424 to the University of California, San Diego from August 1, 2022 to July 31, 2025. The grant will support research developing novel quantitative magnetic resonance imaging techniques to directly image myelin and quantify myelin content and properties in the brain. Specifically, the researchers will use ultra-short echo time sequences with echo...
This $3,109,079 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research at the University of California, Riverside to investigate the role of traumatic brain injury (TBI) across the lifespan in the development of Alzheimer's disease and related dementias (ADRD). The project will use a closed head injury (CHI) TBI mouse model to examine how ADRD risk factors, such as the APOE4 gene and amyloid-beta, interact with TBI at different life stages...