This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to develop multi-analyte algorithms for screening and prognosis of frontotemporal lobar degeneration (FTLD), a family of neurodegenerative proteinopathies. The $2,398,069 award to The Trustees of the University of Pennsylvania will leverage a unique cohort of over 200 pathology-confirmed FTLD cases to pathologically validate biomarkers of neurodegeneration, neuroinflammation, and synaptic...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to comprehensively study glial activation and iron dysregulation in brain tissue samples from patients with Frontotemporal Lobar Degeneration (FTLD). The $803,111 award, which runs from December 2024 to November 2029, will enable researchers at the University of Pennsylvania to model and contrast the microscopic, mesoscopic, and macroscopic progression of neuroinflammation, abnormal iron...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Alabama at Birmingham (UAB) provides $583,558 in funding from September 30, 2024 to August 31, 2025. The project aims to investigate retinal manifestations of Alzheimer's disease (AD) through the following efforts: Tracking the earliest disease indicators in the APP/PS1 mouse model of AD using retinal testing techniques like electroretinography (ERG). Defining a range of normal...
The National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), awarded a $1,076,760 Project Grant to the Vlaams Instituut Voor Biotechnologie (VIB) in Belgium. The grant, which runs from Sep 30, 2024 to Aug 31, 2029, supports research to develop a humanized frontotemporal lobar degeneration (FTLD-TDP) mouse model and identify molecular factors secreted by microglia that contribute to FTLD-related neurodegeneration. Additionally, the project aims to determine the...
The National Institute on Aging (NIA) awarded a $7,249,563 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the Regents of the University of California, San Francisco (UCSF). This 3-year award, starting on Aug 1, 2023, will support research to characterize the structural properties and variability of tau protein aggregation in different brain cell types and at different disease stages of Alzheimer's and related dementias (ADRD). The project aims to develop new...
The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $437,250 project grant to the University of California, San Diego (UCSD). The grant, which runs from May 15, 2025 to April 30, 2027, will fund the development of new tools to image tau protein form and function in living cells. The project aims to create a peptide-based probe that uses aggregation-induced emission (AIE) to directly measure tau as it transitions from a soluble state to...
The National Institute on Aging (NIA) awarded a $1,783,700.00 Project Grant under the Aging Research program (CFDA 93.866) to the University of Illinois to develop novel blood-brain barrier permeable multimodal imaging agents for the diagnosis of neurodegenerative diseases, with a focus on Alzheimer's disease and related dementias. The 3-year grant aims to employ organic and inorganic chemical design principles to generate diagnostic agents capable of detecting protein aggregation,...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research into proteostasis, neuroinflammation, and neurodegeneration in frontotemporal dementia (FTD). The $630,496 award, granted on June 1, 2025, aims to better define alterations in proteostasis in FTD glial cells, including microglia and astrocytes, and determine if proteostasis impairment in glia, neurons, or both drives neurodegeneration in FTD. The research is being conducted by the J....
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $104,164 to Emory University to conduct research on the role of the TMEM106B gene in neurodegenerative disorders, particularly frontotemporal dementia (FTD). The research aims to: 1) Determine the interaction between TMEM106B and the C9ORF72 gene, which is linked to FTD and amyotrophic lateral sclerosis, and 2) Investigate the toxicity of TMEM106B protein aggregates and their impact on...
This Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) provides $2,181,250 in funding to the Seattle Institute For Biomedical And Clinical Research to develop small molecule inhibitors of the MSUT2 protein as a potential therapeutic approach for treating tauopathy disorders such as frontotemporal lobar degeneration, Alzheimer's disease, and related conditions. The project aims to optimize potent and brain-penetrant MSUT2 inhibitors and demonstrate...