Project Grant RF1AG083090
- Federal Project Grant Award Summary Yale University received a $461,146 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded on May 15, 2025, with completion targeted for April 30, 2027. The award funds research investigating the dysregulation of cortical astrocytes in Alzheimer's disease (AD) models. The primary deliverable is novel scientific research employing advanced mesoscopic imaging techniques to longitudinally measure...
- Federal Grant Award Summary Yale University received a $746,160 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded March 20, 2026, with an ultimate completion date of February 28, 2031. The award supports research investigating the mechanisms by which peripheral inflammation interacts with aging to increase dementia risk. The project will deliver scientific knowledge regarding how acute and chronic inflammatory conditions alter...
- Federal Grant Award Summary Yale University received a $544,318 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective June 1, 2026 through May 31, 2031. The award funds research investigating the immunometabolic regulation of inflammaging by nerve-associated macrophages (NAMs)—a specialized subset of macrophages residing on sympathetic nerve fibers. The project will characterize NAM functional heterogeneity, examine how age-related...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded $3.23 million to the University of Kansas Center for Research Inc. under the Aging Research program (CFDA 93.866) to investigate the interplay between neuronal activity, synaptic dysfunction, and mitochondrial dysfunction in Alzheimer's disease. The project, initiated September 30, 2025, and running through August 31, 2029, will utilize mouse models of Alzheimer's disease to examine age-dependent and region-specific...
- Federal Project Grant Award Summary New York University School of Medicine received a $642,063 project grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded on January 15, 2026, with a completion date of December 31, 2030. This award funds research examining gabaergic microcircuits within the hippocampal CA1 region to identify cellular and pathway-specific neuromodulatory targets for Alzheimer's disease (AD) therapeutic intervention. The research employs a...
- Federal Project Grant Award Summary Boston University Medical Campus received a $1,224,405 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective August 1, 2025 through April 30, 2030. The award supports multiscale modeling and empirical studies investigating the mechanisms underlying normal and pathological brain aging, with specific focus on myelin dystrophy, synaptic loss, and neuronal hyperexcitability in the neocortex. The research...
- Federal Grant Award Summary Yale University received a $461,146 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) awarded May 15, 2025, with completion targeted for April 30, 2027. The project, titled "Toward Developing a Navigation Model of the Aging Brain in the Marmoset," focuses on understanding the physiological function and organization of the entorhinal cortex (ERC) in marmosets to advance knowledge of Alzheimer's disease pathology...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded University of California, Irvine $3.22M under the Aging Research program (CFDA 93.866) for a project grant commencing September 15, 2025, with completion scheduled for August 31, 2029. This project will deliver biomedical research services focused on understanding the role of the retrosplenial cortex in Alzheimer's disease (AD) pathogenesis. The research will establish the mechanisms by which neuronal hyperexcitability...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded The Trustees of Columbia University in the City of New York $529,744 on February 15, 2026, under the Aging Research program (CFDA 93.866) to investigate the mechanisms driving Alzheimer's disease (AD) progression through the entorhinal cortex-hippocampal circuit. The research will deliver scientific knowledge regarding the relationship between neuronal hyperactivity, neuroinflammation, and tau pathology in...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded J. David Gladstone Institutes a Project Grant of $1,459,072 on August 1, 2025, under the Aging Research program (CFDA 93.866) to conduct research on Alzheimer's Disease (AD)-related neurological dysfunction. The research will deliver scientific knowledge and methodological innovations focused on understanding how inhibitory interneurons—specifically parvalbumin (PVALB) and somatostatin (SST) cell types—contribute...
The National Institute on Aging (NIA) awarded a $2,168,393 Project Grant (CFDA 93.866) to Yale University to examine the role of kynurenic acid in age-related cognitive deficits. The 3-year grant, starting September 1, 2023, will study how increased kynurenine inflammatory signaling with aging impairs higher cortical function in the dorsolateral prefrontal cortex (DLPFC) through blockade of NMDAR and α7-nAChR receptors, leading to working memory deficits. The research will test strategies to restore DLPFC neuronal firing and working memory performance in aged rhesus monkeys by reducing kynurenic acid production and enhancing cholinergic actions. Findings from this work may provide approaches to protect higher cortical circuits in cognitive disorders associated with elevated kynurenine levels, such as Alzheimer's disease and "long-COVID."
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.2m | 8/21/23 |