This $224,140 Project Grant was awarded by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), for a project titled "Understanding the Relationship Between Cortical Hyperexcitability and the Progression of FTD/ALS Pathology and Behavioral Deficits in Mice". The grant aims to elucidate the mechanisms of circuit dysfunction in frontotemporal dementia (FTD) caused by the C9ORF72 gene, focusing on understanding the relationship between cortical hyperactivity, the progression of C9ORF72 hexanucleotide repeat pathology, and behavioral deficits. The project will leverage state-of-the-art technologies such as multiphoton microscopy, optogenetics, and chemogenetics to monitor neuronal activity, evaluate its relationship to neuronal loss, and determine whether hyperactivity can drive the progression of FTD pathology and behavioral deficits. The goal is to develop effective and timely treatments for FTD. The award period is from September 1, 2024 to August 31, 2026.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $0 | 12/10/24 | ||
| Not listed | $112.1k | 8/28/24 | ||
| Not listed | $112.1k | 8/28/24 |