This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research at Texas Tech University Health Sciences Center (TTUHSC) to study alternative polyadenylation (APA) of mRNAs and its role in the development and progression of Alzheimer's disease (AD). The $310,000 award, with a period of performance from Sep 15, 2024 to Aug 31, 2026, has two main goals: 1) to identify APA genes and pathways associated with AD pathology using computational analysis of...
The National Institute on Aging (NIA), part of the Department of Health and Human Services National Institutes of Health, awarded a $3.37 million Project Grant to The University of Texas at Arlington to develop an individualized deep connectome framework for Alzheimer's disease and related dementias (ADRD) analysis. The three-year grant, awarded on August 18, 2022 under the NIA's Aging Research program (CFDA 93.866), will support research to discover and identify individualized...
The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $1.1M Project Grant to the University of Texas Medical Branch at Galveston (UTMB) for the period of July 15, 2024 to April 30, 2026. The grant supports research to investigate the mechanisms by which amyloid-beta (Aβ) modulates the trans-synaptic spreading of pathological tau in Alzheimer's disease. Specifically, the project aims to determine how Aβ oligomers influence the binding and...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $420,750.00 to Texas Tech University Health Sciences Center (TTUHSC) to conduct research on the role of amyloids and extracellular nucleic acids as structural components of the brain extracellular matrix (ECM). The research aims to establish that these elements are part of the mouse and human brain ECM, and to determine the sex-specific contributions of cystatin-related epididymal...
This federal Project Grant award of $429,000 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research on the role of metal regulatory transcription factor-1 (MTF-1) in neurodegenerative diseases like Alzheimer's, tauopathies, and Lewy body dementia. The research, conducted by the University of Texas Health Science Center at Houston, aims to determine if aberrant MTF-1 activation is necessary and sufficient for driving neurodegeneration in fly models, and to...
The National Institute on Aging (NIA) awarded a $118,557 Project Grant (CFDA 93.866 - Aging Research) to The University of Texas Health Science Center at San Antonio (UTHSCSA) for the project "The Role of SNX19 in Aging Brains at Single Cell Resolution and Cerebral Organoids". The grant, which runs from August 1, 2024 to July 31, 2029, will support UTHSCSA's research to study the mechanism by which the SNX19 protein contributes to Alzheimer's disease and related dementias. The...
The National Institute on Aging (NIA) awarded a $303,449 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the Regents of the University of Michigan. The 2-year grant, effective June 1, 2025 through May 31, 2027, will support research to investigate the prevalence and functional impact of transposable elements (TEs) in Alzheimer's disease (AD) and related dementias (ADRD). The project aims to leverage large genomic and clinical datasets to identify patterns of...
This federal Project Grant award, funded by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), supports research to investigate the role of senescent cells in brain aging and Alzheimer's disease and related dementias (ADRD). The $654,238 award, effective from September 15, 2024 to June 30, 2026, will enable researchers from the University of Texas Health Science Center at San Antonio (UTHSCSA) to generate spatial omics data from ADRD brains and mouse models,...
This $320,000 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research at the University of Texas Medical Branch at Galveston (UTMB) investigating the role of tau protein and alternative polyadenylation (APA) in Alzheimer's disease. The primary objectives are to: 1) Identify and compare mRNA isoform libraries from mouse primary hippocampal neurons expressing wild-type and mutant tau, using the Poly(A)-ClickSeq (PAC-Seq) technology, and 2)...
This $2,114,698 federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research program) will support research at the University of North Texas Health Science Center at Fort Worth to investigate the role of sex and the brain hormone angiotensin II in Alzheimer's disease. The 5-year project aims to determine how sex chromosomes, sex hormones, and brain-derived hormones interact to modulate angiotensin II activation and associated oxidative stress and cognitive...