This federal Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), provides $420,750 to Texas Tech University Health Sciences Center (TTUHSC) to conduct research on the role of amyloids and extracellular nucleic acids in the brain extracellular matrix (ECM) and their contributions to brain plasticity and sex-specific responses.
The key objectives are to: 1) establish that amyloids, including the CRES subgroup, and extracellular nucleic acids are components of the mouse and human brain ECM, and 2) determine the sex-specific contributions of CRES/CRES amyloid to ECM structure using a CRES knockout mouse model. This research aims to identify new structural elements in the brain ECM and propose a novel mechanism by which the ECM can remodel to enable plasticity and sex-specific brain functions. The award period runs from Sep 27, 2024 to Aug 31, 2026.
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