Project Grant RF1AG073593

Award Date 8/15/21
Completion Date 7/31/24
Dollars Obligated $6.2M
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Austin, TX 78759, USA
Similar Awards
The National Institute on Aging (NIA), part of the Department of Health and Human Services National Institutes of Health, awarded a $3.37 million Project Grant to The University of Texas at Arlington to develop an individualized deep connectome framework for Alzheimer's disease and related dementias (ADRD) analysis. The three-year grant, awarded on August 18, 2022 under the NIA's Aging Research program (CFDA 93.866), will support research to discover and identify individualized...
The National Institutes of Health's National Institute on Aging awarded a $7,432,562 project grant to the Regents of the University of California, San Francisco on September 15, 2022 under the Aging Research program (CFDA 93.866). The grant will support research to elucidate the roles of Alzheimer's disease risk genes and variants in gene expression and AD-related phenotypes through 2025. Specifically, the University of California, San Francisco will use CRISPR and single-cell RNA sequencing...
This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $4,041,438 to develop new computational tools and biomarkers for Alzheimer's disease. The University of Miami will aggregate and analyze DNA methylation datasets to identify age-associated epigenetic changes related to aging and Alzheimer's progression. Researchers will create a searchable web interface to disseminate findings on the role of DNA...
This $310,000 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research by Texas Tech University Health Sciences Center (TTUHSC) to examine how alternative polyadenylation (APA) of mRNAs contributes to the development and progression of Alzheimer's disease (AD). The project has two main goals: 1) to identify APA genes and pathways associated with AD pathology using computational analysis of existing single-cell RNA-sequencing datasets, and 2)...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $528,876 to Emory University to conduct research investigating the cis- and trans-genetic regulation of brain transcriptomics and proteomics associated with Alzheimer's disease and related dementias. The 5-year project, beginning June 1, 2025, aims to develop new analytical tools that can integrate transcriptome-wide and proteome-wide association studies with genome-wide association data...
This Project Grant award of $654,238 from the National Institute on Aging (CFDA 93.866 Aging Research program) supports research to identify the role of senescent neurons in brain aging and Alzheimer's disease and related dementias (ADRD). The primary awardee, the University of Texas Health Science Center at San Antonio, will generate spatial omics data from ADRD brains and mouse models, while the co-investigator team at Washington University will provide expertise in experimental design, data...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $1,493,584 to the University of Texas Health Science Center at Houston (UTHealth) from September 30, 2024 to June 30, 2029. The project aims to develop statistical and computational tools for efficient genetic association mapping using identical-by-descent (IBD) segments to identify novel genomic regions associated with Alzheimer's disease and related brain imaging endophenotypes. Key objectives...
The National Institute on Aging (NIA) awarded a $125,896 Project Grant under the Aging Research program (CFDA 93.866) to The Washington University in St. Louis to conduct research on Alzheimer's disease (AD) risk and resilience pathways. The project aims to perform deep molecular characterization of AD genetic risk factors and protective mechanisms using state-of-the-art single-cell multi-omic analyses of healthy and AD human brain tissue, as well as transgenic AD mouse models. Key objectives...
The National Institute on Aging (NIA) awarded a Project Grant (CFDA 93.866 - Aging Research) in the amount of $661,016 to the University of Southern California (USC) to develop a "Federated Deep Learning to Accelerate Alzheimer's Disease Research" project. The key products and services to be delivered include: Establishing an international "Federate AD" alliance to leverage innovative AI techniques and distributed computation to study Alzheimer's disease (AD) across large,...
The National Institute on Aging (NIA) awarded a $3,001,359 Project Grant (CFDA 93.866 - Aging Research) to The Regents of the University of Colorado to conduct a comprehensive scientific investigation into the gene-environment interplay among modifiable risk factors for Alzheimer's disease and related dementias. The project will leverage data from 16 twin samples in the Interplay of Genes and Environments across Studies (IGEMS) consortium, along with 4 additional samples, to clarify which...

This $6.18 million project grant from the National Institutes of Health's National Institute on Aging will fund the University of Texas at Austin to conduct the first large-scale genomic analysis of continuous rates of longitudinal aging-related cognitive change prior to dementia onset. Working with sub-awardees the University of Colorado and the University of Edinburgh, the researchers will identify genetic variants beyond APOE that confer risk for cognitive decline leading to eventual Alzheimer's disease and Alzheimer's disease-related dementias. This will allow them to estimate improved polygenic risk scores to enhance assessment of AD/ADRD risk and identify novel biological pathways that can be targeted for prevention and treatment. The grant's products will be improved understanding of the pathophysiology underlying accelerated cognitive decline during the pre-symptomatic "silent period" prior to dementia diagnoses. This large consortium study aims to overcome limitations of prior research by focusing on continuous cognitive trajectories rather than single-time-point assessments. It will further the goals of the NIH's Aging Research program to increase knowledge of aging and age-related diseases.

Generated 1/6/24, 10:10 AM