Project Grant RF1AG071762
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Massachusetts Medical School is focused on understanding how the gut microbiome influences neurodegeneration and protects against Alzheimer's disease. The $647,979 award, effective September 30, 2024 through August 31, 2025, will leverage the C. elegans model system to: Determine how bacterial production of vitamin B12 protects against neurodegeneration pathways. Examine...
- The University of South Florida (USF) was awarded a $3,297,926 project grant from the National Institute on Aging (CFDA 93.866 - Aging Research) to develop novel biomaterials that can prevent, halt, and potentially cure Alzheimer's disease (AD). The objective of this 4-year project is to advance USF's preliminary work on designing peptide hybrid biomaterials that can stabilize the helical conformation of the amyloid-beta (Aβ) peptide, thereby shifting the equilibrium of Aβ aggregation away...
- This federal Project Grant award of $856,580 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a 5-year research project to investigate the relationship between the gut microbiome and Alzheimer's disease and related dementias (AD/ADRD) in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) cohort. The project aims to elucidate the microbial origins of AD/ADRD in the Latino population, which has double the risk of AD/ADRD compared to non-Latino whites. Key...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $952,090 to the University of Wisconsin-Madison to test the safety and feasibility of a custom probiotic intervention among individuals with Alzheimer's disease (AD) dementia and preclinical AD. The study will enroll participants from the Wisconsin Alzheimer's Disease Research Center in a randomized, double-blind trial. Half of the participants will receive the probiotic intervention,...
- This $484,314 Project Grant was awarded by the National Science Foundation (NSF) Division of Integrative Organismal Systems under the Biological Sciences program (CFDA 47.074). The funding will support research at Christopher Newport University to investigate the "microbiota-gut-brain axis" and the impact of intestinal barrier dysfunction on aging and neurodegeneration. Key objectives include gaining insights into the cellular and molecular changes associated with an aging gut, how...
- The University of Alabama at Birmingham (UAB) has been awarded a $1,869,019 Project Grant by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The funding will support a 3-year research project to investigate the role of circadian rhythms, gut microbiome, and gut-to-brain signaling in the onset and progression of Alzheimer's disease (AD) using a Drosophila (fruit fly) model. Key objectives include determining whether depletion of gut microbiota...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $696,896 to the University of Texas Health Science Center at Houston to conduct research on the impact of the gut microbiome on B cell-mediated neuroinflammation in cerebral amyloid angiopathy (CAA). The research aims to investigate three key hypotheses: (1) CAA induces B cell-driven inflammation in the brain; (2) CAA-induced gut dysbiosis can promote B cell-mediated neuroinflammation...
- The National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), awarded a $412,500 Project Grant to the University of South Florida to investigate changes in the brain extracellular matrix during normal aging and in Alzheimer's disease. The 2-year grant, which runs from Jun 1, 2025 to May 31, 2027, aims to establish region-specific extracellular matrix composition in mouse brains, elucidate changes during normal aging, and characterize temporal and spatial...
- The National Institute on Aging (NIA), part of the U.S. Department of Health and Human Services, awarded a $1,249,957 Project Grant under CFDA 93.866 (Aging Research) to Advantage Therapeutics, Inc. in Florida. The grant aims to perform IND-enabling studies on a small molecule that is disease-modifying, low-cost, and has a long safety record for the treatment of Alzheimer's disease. The proposed molecule is designed to reduce brain inflammation and restore phagocytosis, thereby improving the...
- This federal Project Grant award for $369,823 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research to investigate how SARS-CoV-2 infection and the viral S1 protein may induce cellular senescence in the brain and contribute to the development of Alzheimer's disease. Key research activities include studying the impact of the S1...
The University of South Florida received a $3,385,215 Project Grant award from the National Institute on Aging, part of the National Institutes of Health within the Department of Health and Human Services. The grant was awarded under the Aging Research program (CFDA 93.866) to fund research titled "Microbial Therapy Improves Gut Permeability to Reduce Cognitive Decline and Alzheimer's Disease." The grant will support research from August 2021 through July 2024 to study the impact of increased gut permeability on cognitive decline and Alzheimer's disease in normal aging and Alzheimer's disease mouse models. The research aims to determine if a unique probiotic therapy can reverse changes by restoring the gut mucus barrier. Specifically, the grant will fund research to: 1) define the role of elevated gut permeability on cognitive decline and Alzheimer's disease onset and severity; 2) determine how the probiotic and its lipoteichoic acid promote gut goblet cell differentiation to increase mucin production; and 3) examine strain-specific lipoteichoic acid modifications that impact mucin production. A subaward of $350,000 was also provided to Wake Forest University Health Sciences to support the research objectives. Outcomes are expected to provide new evidence linking aging, cognitive decline, and Alzheimer's disease through increased gut permeability.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.1m | 8/10/21 | ||
| Not listed | $1.1m | 8/10/21 |
GrantNumber | Description | Subgrantee | Prime Award | Dollars Obligated | Updated At |
|---|---|---|---|---|---|
6155105700AMOD1S | Wake Forest University Health Sciences | Project Grant RF1AG071762 | $4.9k | 9/20/23 |